Modifying the cellular transport of DNA-based vaccines alters the immune response to hantavirus nucleocapsid protein

Vaccine

Volumn 19, Issue 28-29, 2001, Pages 3820-3829

  Bucht, Göran ^a   Sjölander, Katarina Brus ^b,c   Eriksson, Solveig ^a   Lindgren, Lena ^a   Lundkvist, Åke ^b,c   Elgh, Fredrik ^a,d,e  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^d Centre for Microbiological Preparedness   (Sweden)

^e UMEÅ UNIVERSITY   (Sweden)

Author keywords

Cellular transport; DNA vaccines; Hantavirus; Immune response; Puumala virus

Indexed keywords

ANTIGEN; DNA VACCINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; NUCLEOCAPSID PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; CELL SECRETION; CELL STRAIN COS1; CELL TRANSPORT; CELLULAR DISTRIBUTION; CODING; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOMODULATION; LYMPH; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PUUMALA VIRUS; SIGNAL TRANSDUCTION; TH1 CELL; VACCINATION; VIRUS HEMORRHAGIC FEVER; VIRUS STRAIN; VOLE;

ANIMALS; ANTIBODIES, VIRAL; ARVICOLINAE; BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; COS CELLS; DNA PRIMERS; HANTAVIRUS; HUMANS; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; NUCLEOCAPSID; NUCLEOCAPSID PROTEINS; PROTEIN SORTING SIGNALS; VACCINES, DNA; VIRAL VACCINES;

EID: 0035898927     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00151-7     Document Type: Article

References (39)

1. Hantaviruses: A global disease problem
2. Epidemiological analysis of morbidity in hemorrhagic fever with renal syndrome in the republic of Bashkortostan
3. Nephropatia epidemica in Finland
4. Nephropatia epidemica in Finland: A retrospective study of 126 cases
5. Serologic evidence of Puumala virus infection in wild moose in northern Sweden
6. Molecular biology of hantaviruses
7. Detection of nephropathia epidemica (Puumala virus)-specific immunoglobulin M by enzyme-linked immunosorbent assay
8. Development of humoral cross-reactivity to the nucleocapsid protein of heterologous hantaviruses in nephropathia epidemica
9. The humoral response to Puumala virus infection (nephropathia epidemica) investigated by viral protein specific immunoassays
10. Characterisation of Puumala virus nucleocapsid protein: Identification of B-cell epitopes and domains involved in protective immunity
11. Chimaeric HBV core particles carrying a defined segment of Puumala hantavirus nucleocapsid protein evoke protective immunity in an animal model
12. Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinats
13. Protective immunity of Hantaan virus nucleocapsid and envelope protein studied using baculovirus-expressed proteins
14. Immunity to hantavirus challenge in Meriones unguiculatus induced by vaccinia-vectored viral proteins
15. Intramuscular inoculation of Sin Nombre hantavirus cDNA induces cellular and humoral immune responses in BALB/c mice
16. DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects against Seoul virus infection
17. Comparison of the protective efficacy of naked DNA, DNA-based Sindbis replicon, and packaged Sindbis replicon vectors expressing Hantavirus structural genes in hamsters
18. Immunology taught by viruses
19. A case for cytokines as effector molecules in the resolution of virus infection
20. Genetic vaccines: Strategies for optimization
21. Differental induction of immunoglobin G subclasses by immunization with DNA vectors containing or lacking signal sequence
22. Comparative study of DNA-based immunization vectors: Effect of secretion signals of antibody response in mice
23. DNA vaccines
24. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure
25. Optimising the signal peptide for glycosyl phosphatidylinositol modification of human acetylcholinesterase using mutational analysis and peptide-quantitative structure-activity relationships
26. The mode of anchorage to the cell surface determines both the function and the membrane location of Thy-1 glycoprotein
27. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: Evidence for strain variation in hantaviruses and expression of the nucleocapsid protein
28. Electroporation for the efficient transfection of mammalian cells with DNA
29. Comparison of the kinetics of Puumala virus specific IgM and IgG antibody responses in Nephropatia Epidemica as measured by recombinant antigen-based enzyme linked immunosorbent assay and immunofluorescence test
30. Removal of endotoxin from protein solutions by phase separation
31. Use of poly(vinylpyrrolidone) and poly(vinyl alcohol) for cryoultramicrotomy
32. Cell culture adaptation of Puumala hantavirus changes the infectivity for its natural reservoir, Cletrionomys glareolus, and leads to accumulation of mutants with altered genomic RNA S segment
33. Distribution and genetic heterogeneity of Puumala virus in Sweden
34. Mammalian GPI proteins: Sorting, membrane resistance and functions
35. GPI-anchored proteins are organized in submicron domains at the cell surface
36. Three-dimensional segregation of supramolecular activation clusters in T cells
37. Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events
38. Cell surface display and intracellular trafficking of free glycosylphosphatidylinositols in mammalian cells
39. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts