Optimising the signal peptide for glycosyl phosphatidylinositol modification of human acetylcholinesterase using mutational analysis and peptide-quantitative structure-activity relationships

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1431, Issue 2, 1999, Pages 471-482

  Bucht, Göran ^a   Wikström, Per ^a   Hjalmarsson, Karin ^a  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

Author keywords

+1 residue; +2 residue; Glycosyl phosphatidylinositol anchoring; Human acetylcholinesterase; Peptide quantitative structure activity relationship; Spacer region

Indexed keywords

ACETYLCHOLINESTERASE; AMINO ACID; GLYCOSYLPHOSPHATIDYLINOSITOL; MUTANT PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA SEQUENCE; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HYDROPHOBICITY; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; COS CELLS; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; MUTATION; PEPTIDE MAPPING; PROTEIN SORTING SIGNALS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0032929059     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(99)00079-5     Document Type: Article

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