Tamoxifen but Not 4-Hydroxytamoxifen Initiates Apoptosis in p53(-) Normal Human Mammary Epithelial Cells by Inducing Mitochondrial Depolarization

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 5384-5394

  Dietze, Eric C ^a   Caldwell, L Elizabeth ^b   Grupin, Svetlana L ^a   Mancini, Mariangela ^c   Seewaldt, Victoria L ^a,d  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF PADOVA   (Italy)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DNA; GENES; PROTEINS; TUMORS;

APOPTOSIS; MITOCHONDRIAL DEPOLARIZATION;

CELLS;

4 HYDROXYTAMOXIFEN; CASPASE; DNA FRAGMENT; LIPOCORTIN 5; PROTEIN P53; TAMOXIFEN; VIRUS PROTEIN; 4-HYDROXYTAMOXIFEN; ANTIESTROGEN; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; ONCOPROTEIN; REPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER INHIBITION; CANCER MODEL; CANCER PREVENTION; CELL STRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPOLARIZATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESISTANCE; DRUG TARGETING; DRUG UTILIZATION; ENZYME ACTIVATION; ENZYME ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOLECULAR WEIGHT; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROVIRUS; WART VIRUS; BREAST; CELL DIVISION; CELL LINE; CELL MEMBRANE POTENTIAL; CULTURE TECHNIQUE; CYTOLOGY; EPITHELIUM CELL; FEMALE; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; MITOCHONDRION; PHYSIOLOGY; ULTRASTRUCTURE;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPES; PAPILLOMAVIRUS; UNIDENTIFIED RETROVIRUS;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BREAST; CASPASES; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPITHELIAL CELLS; ESTROGEN ANTAGONISTS; FEMALE; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; ONCOGENE PROTEINS, VIRAL; REPRESSOR PROTEINS; TAMOXIFEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035895973     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007915200     Document Type: Article

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