Cardioprotective therapy and sodium-hydrogen exchange inhibition: Current concepts and furore goals

Journal of the American College of Cardiology

Volumn 38, Issue 6, 2001, Pages 1651-1653

  Menown, Ian B A ^a   Adgey, A A Jennifer ^a  

^a ROYAL VICTORIA HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; AMILORIDE; ANTIANGINA PECTORIS AGENT; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENIPORIDE; NICORANDIL; PROTON SODIUM EXCHANGE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANGINA PECTORIS; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FIBRINOLYTIC THERAPY; HEART INFARCTION SIZE; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; NOTE; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SIDE EFFECT; TREATMENT OUTCOME;

EID: 0035890033     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(01)01607-2     Document Type: Editorial

References (23)

1. The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction
2. Randomised trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2
3. Reperfusion injury: Experimental evidence and clinical implications
4. Progression of myocardial necrosis during reperfusion of ischemic myocardium
5. Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction. Observations from the TIMI-14 trial
6. Ischaemic preconditioning: Present position and future directions
7. Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: Distant dream or near reality?
8. Prolonging the delayed phase of myocardial protection: Repetitive adenosine A1 receptor activation maintains rabbit myocardium in a preconditioned state
9. Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart
10. Trial to show the Impact Of Nicorandil in Angina (IONA): Design, methodology, and management
11. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: Results of a multicenter, randomized, placebo-controlled trial: The Acute Myocardial Infarction Study of Adenosine (AMISTAD) trial
12. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: An overview of randomized placebo-controlled trials
13. Myocardial cell protection. A challenging time for action and a challenging time for clinical research
14. The sodium-hydrogen exchange system in the heart: Its role in ischemic and reperfusion injury and therapeutic implications
15. Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642)
16. A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before and after coronary artery occlusion
17. + exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion
18. A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE-642 (cariporide)
19. + exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA
20. Inhibition of the sodium-hydrogen exchanger with cariporlde to prevent myocardial infarction in high-risk ischemic situations: Main results of the GUARDIAN trial
21. + exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the Evaluation of the Safety and Cardioprotective effects of eniporide in Acute Myocardial Infarction (ESCAMI) trial
22. Multinuclear MR-spectroscopy on ion-homeostasis and energetics during ischaemia and reperfusion
23. A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporlde, reduces ischemic myocardial injury in vitro and in vivo