Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction: Observations from the TIMI 14 trial

Circulation

Volumn 101, Issue 3, 2000, Pages 239-243

  De Lemos, James A ^a   Antman, Elliott M ^a   Gibson, C Michael ^b   McCabe, Carolyn H ^a   Giugliano, Robert P ^a   Murphy, Sabina A ^b   Coulter, Stephanie A ^a   Anderson, Keaven ^c   Scherer, Joel ^d   Frey, Martin J ^e   Van Der Wieken, R ^f   Van De Werf, Frans ^g   Braunwald, Eugene ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CENTOCOR INC   (United States)

^d ELI LILLY AND COMPANY   (United States)

^e Heart Center   (United States)

^f Afdeling Cardiologie   (Netherlands)

^g UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Electrocardiography; Microcirculation; Myocardial infarction; Reperfusion; Thrombolysis

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; HEPARIN; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ELECTROCARDIOGRAPHY MONITORING; FEMALE; HEART INFARCTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE REPERFUSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION; TREATMENT OUTCOME;

EID: 0034711702     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.3.239     Document Type: Article

References (29)

1. The GUSTO Angiographic Investigators. The comparative effects of tissue plasminogen activator, streptokinase, or both on coronary artery patency, ventricular function and survival after acute myocardial infarction. N Engl J Med. 1993;329:1615-1622.
2. Vogt A, von Essen R, Tebbe U, Feuerer W, Appel K-F, Neuhaus K-L. Impact of early perfusion status of the infarct-related artery on short-term mortality after thrombolysis for acute myocardial infarction: retrospective analysis of four German multicenter studies. J Am Coll Cardiol. 1993; 21:1391-1395.
3. Lincoff AM, Topol EJ. Illusion of reperfusion: does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation. 1993;87:1792-1805.
4. Ito H, Tomooka T, Sakai N, Yu H, Higashino Y, Fujii K, Masuyama T, Kitabatake A, Minamino T. Lack of myocardial perfusion immediately after successful thrombolysis: a predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation. 1992;85: 1699-1705.
5. Sakuma T, Hayashi Y, Sumii K, Imazu M, Yamakido M. Prediction of short- and intermediate-term prognosis of patients with acute myocardial infarction using myocardial contrast echocardiography one day after recanalization. J Am Coll Cardiol. 1998;32:890-897.
6. Porter TR, Li S, Oster R, Deligonul U. The clinical implications of no reflow demonstrated with intravenous perfluorocarbon containing microbubbles following restoration of Thrombolysis in Myocardial Infarction (TIMI) 3 flow in patients with acute myocardial infarction. Am J Cardiol. 1998;82:1173-1177.
7. Santoro GM, Valenti R, Buonamici P, Bolognese L, Cerisano G, Moschi G, Trapani M, Antoniucci D, Fazzini PF. Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echo-cardiography in patients with acute myocardial infarction treated with direct angioplasty. Am J Cardiol. 1998;82:932-937.
8. van't Hof A, Liem A, de Boer M, Zijlstra F. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Lancet. 1997;350:615-619.
9. Somitsu Y, Nakamura M, Degawa T, Yamaguchi T. Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. Am J Cardiol. 1997;80:406-410.
10. Claeys MJ, Bosmans J, Veenstra L, Jorens P, De Raedt H, Vrints CJ. Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. J Am Coll Cardiol. 1999;99:1972-1977.
11. Schroeder R, Wegscheider K, Schroder K, Dissmann R, Meyer-Sabellek W, for the INJECT Trial Group. Extent of early ST-segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens. A substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. J Am Coll Cardiol. 1995;26:1657-1664.
12. Neumann FJ, Blasini R, Schmitt C, Alt E, Dirschinger J, Gawaz M, Kastrati A, Schomig A. Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation. 1998;98:2695-2701.
13. Antman EM, Giugliano RP, Gibson CM, McCabe CH, Coussement P, Kleiman NS, Vahanian A, Adgey AAJ, Menown I, Rupprecht H-J, Van der Wieken R, Ducas J, Scherer J, Anderson K, Van de Werf F, Braunwald E, for the Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators. Abciximab facilitates the rate and extent of thrombolysis: results of Thrombolysis in Myocardial Infarction (TIMI) 14 trial. Circulation. 1999;99:2720-2732.
14. de Lemos JA, Antman EM, Giugliano RP, McCabe CH, Murphy SA, Gibson CM, Braunwald E, for the Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators. ST-segment resolution and infarct related artery patency and flow after thrombolytic therapy. Am J Cardiol. In press.
15. Schröder R, Dissmann R, Bruggemann T, Wegscheider K, Linderer T, Tebbe U, Neuhaus K-L. Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. J Am Coll Cardiol. 1994;24:384-391.
16. TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) Trial: phase I findings. N Engl J Med. 1985;312:932-936.
17. Gibson CM, Cannon CP, Daley WL, Dodge JT, Alexander B, Marble SJ, McCabe CH, Raymond L, Fortin T, Poole WK, Braunwald E, for the TIMI 4 Study Group. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93:879-888.
18. Clemmensen P, Ohmann E, Sevilla D, Peck S, Wagner N, Quigley P, Grande P, Lee K, Wagner G. Changes in standard electrocardiographic ST-segment elevation predictive of successful reperfusion in acute myocardial infarction. Am J Cardiol. 1990;66:1407-1411.
19. Krucoff M, Croll M, Pope J, Granger C, O'Connor W, Sigmon K, Wagner B, Ryan J, Lee K, Kereiakes D, Samaha J, Worley S, Ellis S, Wall T, Topol E, Califf R. Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study: performance of a noninvasive method for real-time detection of failed myocardial reperfusion. Circulation. 1993; 88:437-446.
20. Doevendans PA, Gorgels AP, van der Zee R, Partouns J, Bar FW, Wellens HJJ. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardial infarction. Am J Cardiol. 1995; 75:1206-1210.
21. Mauri F, Maggioni AP, Franzosi MG, De Vita C, Santoro E, Santoro L, Giannuzzi P, Tognoni G, for the GISSI-2 Investigators. A simple electrocardiographic predictor of the outcome of patients with acute myocardial infarction treated with a thrombolytic agent: a GISSI-2 derived analysis. J Am Coll Cardiol. 1994;24:600-607.
22. Santoro G, Antoniucci D, Valenti R, Bolognese L, Buonamici P, Trapani M, Boddi V, Fazzini P. Rapid reduction of ST-segment elevation after successful direct angioplasty in acute myocardial infarction. Am J Cardiol. 1997;80:685-689.
23. Maes A, Van de Werf F, Nuyts I, Bormans G, Desmet W, Mortelmans L. Impaired myocardial tissue perfusion early after successful thrombolysis. Impact on myocardial flow, metabolism, and function at late follow-up. Circulation. 1995;92:2072-2078.
24. Kondo M, Nakano A, Saito D, Shimono Y. Assessment of "microvascular no-reflow phenomenon" using technetium-99 m macroaggregated albumin scintigraphy in patients with acute myocardial infarction. J Am Coll Cardiol. 1998;32:898-903.
25. Koch K-C, vom Dahl J, Kleinhans E, Klues HG, Radke PW, Ninnemann S, Schulz G, Buell U, Hanrath P. Influence of a platelet GP IIb/IIIa receptor antagonist on myocardial hypoperfusion during rotational atherectomy as assessed by myocardial Tc-99 m Sestamibi scintigraphy. J Am Coll Cardiol. 1999;33:998-1004.
26. Gurbel P, Serebruany V, Shustov A, Bahr R, Carpo C, Ohman E, Topol E. Effects of reteplase and alteplase on platelet aggregation and major receptor expression during the first 24 hours of acute myocardial infarction treatment. J Am Coll Cardiol. 1998;21:1466-1473.
27. Murphy JF, Bordet JC, Wyler B, Rissoan MC, Chomarat P, Defrance T, Miossec P, McGregor JL. The vitronectin receptor (avb3) is implicated, in cooperation with P-selectin and platelet activating factor, in the adhesion of monocytes to activated endothelial cells. Biochem J. 1994; 304:537-542.
28. Gawaz M, Neumann FJ, Dickfeld T, Reininger A, Adelsberger H, Gebhardt A, Schomig A. Vitronectin receptor (avB3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction. Circulation. 1997;96: 1809-1818.
29. Simon DI, Xu H, Ortlepp S, Rogers C, Rao NK. 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1. Arterioscler Thromb Vasc Biol. 1997;17:528-535.