The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: Revising the mutator hypothesis

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7369-7374

  Fishel, R ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; MUTANT PROTEIN; PROTEIN MMR; PROTEIN P53; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; CARCINOGENESIS; COLORECTAL CANCER; DNA METABOLISM; DNA REPAIR; GENE MUTATION; HUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BASE PAIR MISMATCH; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA REPAIR; HUMANS; MUTATION;

EID: 0035886816     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Mutator phenotype may be required for multistage carcinogenesis
2. A mutator phenotype in cancer
3. Genetic pathways in colorectal and other cancers
4. Karyotypic evolution in human malignant melanoma
5. Genetic alterations during colorectal-tumor development
6. Tumor-suppressive pathways in pancreatic carcinoma
7. A factor (or mutator gene) influencing mutation rates in Escherichia coli
8. Identification of mismatch repair genes and their role in the development of cancer
9. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
10. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
11. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer
12. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
13. The expanding role of cell cycle regulators
14. The clonal evolution of tumor populations
15. Germ-line msh6 mutations in colorectal cancer families
16. Mediating mismatch repair
17. Cancer of the microsatellite mutator phenotype
18. Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3
19. 6-methylguanine DNA adducts on the adenosine nucleotide switch functions of hMSH2-hMSH6 and hMSH2-hMSH3
20. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
21. Mismatch repair, molecular switches, and signal transduction
22. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
23. Signaling mismatch repair in cancer
24. The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
25. The crystal structure of DNA mismatch repair protein MutS binding to a G X T mismatch
26. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA
27. Methyl-directed DNA mismatch correction
28. Nucleotide-promoted release of hMutS α from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
29. Guarding against mutation
30. Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
31. Crystal structure and ATPase activity of MutL: Implications for DNA repair and mutagenesis
32. The interaction of Ras with GTPase-activating proteins
33. Mismatch correction at O6-methylguanine residues in E. coli DNA
34. Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage
35. The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin
36. Cisplatin and Adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line
37. Human MutSα specifically binds to DNA containing aminofluorene and acetylaminofluorene adducts
38. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
39. Prognostic significance of molecular biological and immunohistological parameters in gastrointestinal carcinomas
40. Apoptosis induced by overexpression of hMSH2 or hMLH1
41. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
42. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
43. 2-M cell cycle checkpoint arrest following ionizing radiation
44. Levels of p53 protein increase with maturation in human hematopoietic cells
45. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
46. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
47. 2 cell cycle checkpoint
48. Self-distruction and tolerance in resistance of mammalian cells to alkylation damage
49. Loss of DNA mismatch repair in acquired resistance to cisplatin
50. An update of HNPCC (Lynch syndrome)
51. Heredity with reference to carcinoma
52. Hereditary factors in cancer. Study of two large Midwestern kindreds
53. Management of hereditary site-specific colon cancer
54. Mutator phenotype in human colorectal carcinoma cell lines
55. Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/-p53-/colonocytes
56. The complexity of p53 modulation: Emerging patterns from divergent signals
57. BRCA1, BRCA2, and DNA damage response: Collision or collusion?
58. The mammalian Mre11-Rad50-nbs1 protein complex: Integration of functions in the cellular DNA-damage response
59. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
60. The DNA double-strand break repair gene hMR11 is mutated in individuals with an ataxiatelangiectasia-like disorder
61. Multiple functions of MutS- and MutL-related heterocomplexes