Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/- p53-/- colonocytes

Cancer Research

Volumn 59, Issue 23, 1999, Pages 5882-5886

  Sevignani, Cinzia ^a   Cranston, Aaron ^a   Iozzo, Renato V ^a   Fishel, Richard ^a   Calabretta, Bruno ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID METHYL ESTER; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL TRANSFORMATION; COLORECTAL CANCER; GENE INACTIVATION; IMMUNE DEFICIENCY; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; KNOCKOUT MOUSE; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BASE PAIR MISMATCH; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COLON; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; GENES, P53; INTESTINAL MUCOSA; MALE; METHYL METHANESULFONATE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, SCID; MUTS HOMOLOG 2 PROTEIN; PROTO-ONCOGENE PROTEINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033405633     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
2. Kinzler, K. W., and Vogelstein, B. Lessons from hereditary colorectal cancer. Cell, 87: 159-170, 1996.
3. Loeb, L. A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res., 5: 3075-3079, 1991.
4. Hartwell, L. Defects in cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell, 71: 543-546, 1992.
5. Lynch, H. T., and Smyrk, T. C. Hereditary nonpolyposis colorectal cancer (Lynch syndrome): an update review. Cancer (Phila.), 78: 1149-1157, 1996.
6. Cohen, P. R., Kohn, S. R., and Kuzrock, R. Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome. Am. J. Med., 90: 606-613, 1991.
7. Fishel, R., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Gerber, J., Kane, M., and Kolodner, R. The human mutator homolog MSH2 and its association with hereditary non-polyposis colon cancer. Cell, 75: 1927-1038, 1993.
8. Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J. R., Parsons, R., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nystrom-Lahti, M., Guan, X-Y., Zhang, L., Meltzer, P. S., Yu, J-W., Kao, F. T., Chen, D. J., Cerosaletti, K. M., Fournier, R. E. K., Todd, S., Lewis, T., Leach, R. J., Naylor, S. L., Weissenbach, J., Mecklin, J. P., Jarvinen, H., Petersen, G. M., Hamilton, S. R., Green, J., Jass, J., Watson, P., Lynch, H. T., Trent, J. M., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75: 1215-1225, 1993.
9. Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J., Lindblom, A., Tannergard, P., Ballag, R. J., Godwin, A. R., Ward, D. C., Nordenskjal, M., Fishel, R., Kolodner, R., and Liskay, R. M. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (Lond.), 368: 258-261, 1994.
10. Liu, B., Parsons, R. E., Hamilton, S. R., Petersen, G. M., Lynch, H. T., Watson, P., Markowitz, S., Wilson, J. K., Green, J., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. hMSH2 mutations in hereditary nonpolyposis colorectal cancer kinetics. Cancer Res., 54: 4590-4594, 1994.
11. Nicolaides, N. C., Papadopoulos, N., Liu, B., Wei, Y. F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischman, R. D., and Fraser, C. M., Adams, M. D., Venter, J. C., Hamilton, S. R., Petersen, G. M., de la Chapelle, A., Vogelstein, B., and Kinzler, K. W. Mutation of a PMS homologue in hereditary nonpolyposis colon cancer. Nature (Lond.), 371: 75-80, 1994.
12. Miyaki, M., Konish, M., Yamada, T., Nagasaki, H., Tsuchiya, R., Muraoka, M., Yasuno, M., Igari, T., Koike, M., Chiba, M., and Mori, T. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat. Genet., 17: 271-272, 1997.
13. Hemminki, A., Peltomaki, P., Mecklin, J. P., Jarvinen, H., Salovaara, R., Nystrom-Lahti, M., de la Chapelle, A., and Aaltonen, L. A. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat. Genet., 8: 405-410, 1994.
14. Lu, S-L., Akiyama, Y., Nagasaki, H., Nomizu, T., Ikeda, E., Baba, S., Ushio, K., Iwama, T., Mayuyama, K., and Yuasa, Y. Loss or somatic mutations of hMSH2 germline mutations. Jpn. J. Cancer Res., 87: 279-287, 1990.
15. Bubb, V. J., Curtis, L. J., Cunningham, C., Dunlop, M., G., Carothers, A. D., Morris, R. G., White, S., Bird, C. C., and Wyllie, A. H. Microsatellite instability and the role of HMSH2 in sporadic colorectal cancer. Oncogene, 12: 2641-2649, 1996.
16. Herfarth, K. K-F., Kodner, I. J., Whelan, A. J., Ivanovich, J. L., Bracamontes, J. R., Wells, S. A., and Goodfellow, P. J., Jr. Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal cancers with microsatellite instability. Genes Chromosomes Cancer, 18: 492-493, 1997.
17. Wu, Y., Nyström-Lathi, M., Osinga, J., Looman, M. W. G., Peltomäki, P., Aaltonen, L. A., de la Chapelle, A., Hofstra, R. M. W., and Buys, C. H. C. M. MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis. Genes Chromosomes Cancer, 18: 269-278, 1997.
18. Wooster, R., Cleton-Jansen, A. M., Collins, N., Mangion, J., Cornelis, R. S., Cooper, C. S., Gusterson, B. A., Ponder, B. A., Von Diemling, A., Wiestler, D. D., Cornelisse, C. J., Deville, P., and Stratton, M. R. Instability of short tandem repeats (microsatellites) in human cancers. Nat. Genet., 6: 152-156, 1994.
19. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Luttenbaughm, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Wilson, J. K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 26: 1336-1338, 1995.
20. Rampino, N., Yamamoto, H., lonov, Y., Li, Y., Sawai, H., Reed, J. C., and Perucho, M. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (Washington DC), 275: 967-969, 1997.
21. Ouyang, H., Shiwaku, H. O., Hagiwara, H., Muira, K., Abe, T., Kato, Y., Ohtani, H., Shiiba, K., Souza, R. F., Meltzer, S. J., and Horii, A. The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum. Cancer Res., 57: 1851-1854, 1997.
22. de Wind, N., Dekker, M., Berns, A., Radman, M., and te Riele, H. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hypercombination, and predisposition to cancer. Cell, 82: 321-330, 1995.
23. Reitmair, A. H., Schnits, R., Ewel, A., Bapat, B., Redston, M., Mitri, A., Waterhouse, P., Mittrucker, H. W., Wakeman, A., Liu, B., Thomason, A., Griesser, H., Gallinger, S., Ballhausen, W. G., Fishel, R., and Mak, T. W. MSH2-deficient mice are viable and susceptible to lymphoid tumors. Nat. Genet., 11: 64-70, 1995.
24. Reitmair, A. H., Redston, M., Cai, J. C., Chuang, T. C. Y., Bjerknes, M., Cheng, H., Hay, K., Gallinger, S., Bapat, B., and Mak, T. W. Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res., 56: 3842-3849, 1996.
25. Sevignani, C., Wlodarski, P., Kirillova, J., Mercer, W. E., Danielson, K. G., Iozzo, R. V., and Calabretta, B. Tumorigenic conversion of p53-deficient colon epithelial cells by an activated Ki-ras gene. J. Clin. Investig., 101: 1572-1580, 1998.
26. Cranston, A., Bocker, T., Reitmair, A., Palazzo, J., Wilson, T., Mak, T., and Fishel, R. Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat. Genet., 17: 114-118, 1997.
27. Danielson, K., Martinez-Hernandez, A., Hassell, J. R., and Iozzo, R. V. Characterization of a basement membrane-producing cell line from the EHS tumor. Matrix, 11: 22-35, 1992.
28. Ouyang, H., Furukawa, T., Abe, T., Kato, Y., and Horii, A. The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium. Clin. Cancer Res., 4: 1071-1074, 1998.
29. Orimo, H., Ikejima, M., Nakajima, E., Emi, M., and Shimada, T. A novel missense mutation and frameshift mutations in the type II receptor of transforming growth factor-β gene in sporadic colon cancer with microsatellite instability. Mut. Res., 382: 115-120, 1998.
30. De Weese, T. L., Shipman, J. M., Lanier, N. A., Buckley, N. M., Kidd, L. R., Groopman, J. D., Cutler, R. G., te Riele, H., and Nelson, W. G. Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. Proc. Natl. Acad. Sci. USA, 95: 11915-11920. 1998.
31. Zhang, H., Richards, B., Wilson, T., Lloyd, M., Cranston, A., Thorburn, A., Fishel, R., and Meuth, M. Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res., 59: 3021-3027, 1999.
32. Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Muraoka, M., Onda, A., Okumura, Y., Kishi, N., Iwama, T., Mori, T., Koike, M., Ushio, K., Chiba, M., Nomizu, S., Konishi, F., Utsunomiya, J., and Miyaki, M. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology, 111: 307-317, 1996.
33. Losi, L., Ponz de Leon, M., Jirieny, J., Di Gregorio, C., Benatti, P., Percesepe, A., Fante, R., Rancucci, L., Pedroni, M., and Benhattar, J. K-ras and p53 mutations in hereditary non-polyposis colorectal cancers. Int. J. Cancer, 74: 94-96, 1997.
34. Tannegard, P., Liu, T., Weger, A., Nordenskjold, M., and Lindblom, A. Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer. Hum. Genet., 101: 51-55, 1997.
35. Yamamoto, H., Sawai, H., Weber, T. K., Rodriguez-Bigas, M. A., and Perucho, M. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Cancer Res., 58: 997-1003, 1998.
36. Maeda, K., Nishiguchi, Y., Onoda, N., Otani, H., Nakata, B., Yamada, S., Okuno, M., Sowa, M., and Chung, K. H. Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer. Int. J. Oncol., 13: 1147-1151, 1998.