Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination

Journal of Immunology

Volumn 167, Issue 6, 2001, Pages 3383-3390

  Anguita, J ^a   Thomas, V ^a   Samanta, S ^a   Persinski, R ^a   Hernanz, C ^a   Barthold, S W ^a   Fikrig, E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12;

ADAPTATION; ANTIGENIC VARIATION; ARTICLE; BORRELIA BURGDORFERI; CYTOKINE PRODUCTION; GENE LOCUS; GENE SEQUENCE; GENETIC RECOMBINATION; IMMUNOCOMPETENCE; INFLAMMATION; LYME DISEASE; NONHUMAN; PRIORITY JOURNAL; SPIROCHETE; SURVIVAL;

EID: 0035884821     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.6.3383     Document Type: Article

References (60)

1. Lyme disease
2. Lyme disease
3. Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues
4. Effect of anti-interleukin 12 treatment on murine lyme borreliosis
5. Role of IL-4 and IFN-γ in modulation of immunity to Borrelia burgdorferi in mice
6. T cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice
7. The T helper cell response in Lyme arthritis: Differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis
8. T helper phenotype and genetic susceptibility in experimental Lyme disease
9. T cell cytokine pattern in the joints of patients with Lyme arthritis and its regulation by cytokines and anticytokines
10. Cytokines in murine Lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain
11. Recombinant IL-4 treatment augments resistance to Borrelia burgdorferi infections in both normal susceptible and antibody-deficient susceptible mice
12. Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
13. Antigenic variation of surface proteins of Borrelia species
14. Induction of interleukin-I release by high- and low-passage isolates of Borrelia burgdorferi
15. Lyme borreliosis in laboratory animals: Effect of host species and in vitro passage of Borrelia burgdorferi
16. Changes in infectivity and plasmid profile of the Lyme disease spirochete. Borrelia burgdorferi, as a result of in vitro cultivation
17. Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi
18. Low-passage-associated proteins of Borrelia burgdorferi B31: Characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein
19. Correlation between plasmid content and infectivity in Borrelia burgdorferi
20. Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1
21. Dissociation of infectivity and pathogenicity in Borrelia burgdorferi
22. Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity
23. Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes
24. Cryptic and exposed invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi
25. C-terminal invariable domain of VlsE may not serve as target for protective immune response against Borrelia burgdorferi
26. Kinetics and in viva induction of genetic variation of vise in Borrelia burgdorferi
27. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi
28. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
29. Transforming growth factor-β in leishmanial infection: A parasite escape mechanism
30. Immune evasion by tickborne and host-adapted Borrelia burgdorferi
31. Borrelia burgdorferi genes selectively expressed in the infected host
32. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
33. Serum-mediated resolution of Lyme arthritis in mice
34. Expression of a functional high-affinity IgG receptor. FcγRI, on human mast cells: Up-regulation by IFN-γ
35. Conservation and heterogeneity of vlsE among human and tick isolates of Borrelia burgdorferi
36. Genetic and Immunological analyses of Vls (VMP-like sequences) of Borrelia burgdorferi
37. Arthropod- and host-specific gene expression by Borrelia burgdorferi
38. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
39. Temperature-related differential expression of antigens in the Lyme disease spirochete Borrelia burgdorferi
40. Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria
41. Cell-density-dependent expression of Borrelia burgdorferi lipoproteins in vitro
42. Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids
43. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host
44. Bacterial perturbation of cytokine networks
45. Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: A possible role in the mechanism of infection
46. Interleukin-2 and granulocyte-macrophage colony-stimulating factor stimulate growth of a virulent strain of Escherichia coli
47. Recombinant interleukin-6 increases the intracellular and extracellular growth of Mycobacterium avium
48. Identification of cytokines which enhance (CSF-I, IL-3) or restrict (IFN-γ) growth of intramacrophage Listeria monocytogenes
49. Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-β1
50. Enhancement of growth of virulent strains of Escherichia coli by interleukin-1
51. Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway
52. Dual role for transforming growth factor β-dependent signaling in Trypanosoma cruzi infection of mammalian cells
53. 14C]-tyrosine uptake in females maintained in vitro
54. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A
55. Adherence of Borrelia burgdorferi to the proteoglycan decorin
56. Identification of a 47-kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31
57. Fibronectin-binding activity in Borrelia burgdorferi
58. Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission
59. + T cells
60. Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter