Serum-mediated resolution of Lyme arthritis in mice

Laboratory Investigation

Volumn 74, Issue 1, 1996, Pages 57-67

  Barthold, Stephen W ^a   DeSouza, Mark ^b   Feng, Sunlian ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; OUTER MEMBRANE PROTEIN; RECOMBINANT PROTEIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; DISEASE SEVERITY; IMMUNOHISTOCHEMISTRY; LYME DISEASE; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; SERUM; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BACTERIAL; ARTHRITIS, INFECTIOUS; BORRELIA BURGDORFERI GROUP; IMMUNE SERA; IMMUNIZATION, PASSIVE; IMMUNOTHERAPY, ADOPTIVE; LYME DISEASE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, SCID; T-LYMPHOCYTES;

EID: 0030033171     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Armstrong AL, Barthold SW, Persing DH, and Beck DS (1992). Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi. Am J Trop Med Hyg 47:249-258.
2. Asbrink E and Hovmark A (1985). Successful cultivation of spirochetes from skin lesions of patients with erythema chronica migrans afzelius and acrodermatitis chonica atrophicans. Acta Pathol Microbiol Immunol Scand [C] 93: 161-163.
3. Barbour AG (1984). Isolation and cultivation of Lyme disease spirochetes. Yale J Biol Med 57:521-525.
4. Barthold SW (1993). Antigenic stability of Borrelia burgdorferi during chronic infections of immunocompetent mice. Infect Immun 61:4955-4961.
5. Barthold SW, Beck DS, Hansen GM, Terwilliger GA, and Moody KD (1990). Lyme borreliosis in selected strains and ages of laboratory mice. J Infect Dis 162:133-138.
6. Barthold SW and Bockenstedt LK (1993). Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect Immun 61:4696-4702.
7. Barthold SW and deSouza MS (1995). Exacerbation of Lyme arthritis in beige mice. J Infect Dis 172:778-784.
8. Barthold SW, deSouza MS, Janotka JL, Smith AL, and Persing DH (1993). Chronic Lyme borreliosis in the laboratory mouse. Am J Pathol 143:951-971.
9. Barthold SW, Fikrig E, Bockenstedt LK, and Persing DH (1995a). Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect Immun 63:2255-2261.
10. Barthold SW, Levy SA, Fikrig E, Bockenstedt LK, and Smith AL (1995b). Serologic response of naturally exposed or vaccinated dogs to Borrelia burgdorferi, the agent of Lyme borreliosis. J Am Vet Med Assoc 207:1435-1440.
11. Barthold SW, Persing DH, Armstrong AL, and Peeples RA (1991). Kinetics of Borrelia burgdorferi dissemination and evolution of disease following intradermal inoculation of mice. Am J Pathol 139:263-273.
12. Barthold SW, Sidman CL, and Smith AL (1992). Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency. Am J Trop Med Hyg 47:605-613.
13. Bradley JF, Johnson RC, and Goodman JL (1994). The persistence of spirochetal nucleic acids in active Lyme arthritis. Ann Intern Med 120:487-489.
14. Burkot TR, Piesman J, and Wirtiz RA (1994). Quantitation of the Borrelia burgdorferi outer surface protein A in Ixodes scapularis: Fluctuations during the tick life cycle, doubling time, and loss while feeding. J Infect Dis 170:883-889.
15. Callister SM, Schell RF, Case KL, Lovrich SD, and Day SP (1993). Characterization of the borreliacidal antibody response to Borrelia burgdorferi in humans: A serodiagnostic test. J Infect Dis 167:158-164.
16. Callister SM, Schell RF, and Lovrich SD (1991 ). Lyme disease assay which detects killed Borrelia burgdorferi. J Clin Microbiol 29:1773-1776.
17. Champion CI, Blanco DR, Skare JT, Haake DA, Giladi M, Foley D, Miller JN, and Lovett MA (1994). A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: Evidence for expression only during infection. Infect Immun 62:2653-2661.
18. deSilva A, Telford SM, Brunet LR, Barthold SW, and Fikrig E.(1995). Borrelia burgdorferi OspA: An arthropod-specific Lyme disease vaccine. J Exp Med in press.
19. deSouza MS, Fikrig E, Smith AL, Flavell RA, and Barthold SW (1992). Nonspecific proliferate responses of murine lymphocytes to Borrelia burgdorferi antigens. J Infect Dis 165: 471-478.
20. deSouza MS, Smith AL, Beck DS, Kim LJ, Hansen GM Jr, and Barthold SW (1993a). Variant responses of mice to Borrelia burgdorferi depending on the site of intradermal inoculation. Infect Immun 61:4493-4497.
21. deSouza MS, Smith AL, Beck DS, Terwilliger GA, Fikrig E, and Barthold SW (1993b). Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse. Infect Immun 61:1814-1822.
22. Fikrig E, Barthold SW, Kantor FS, and Flavell RA (1990). Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250:553-556.
23. Fikrig E, Barthold SW, Marcantonio N, Deponte K, Kantor FS, and Flavell RA (1992a). Roles of OspA, OspB and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect Immun 60:657-661.
24. Fikrig E, Bockenstedt LK, Barthold SW, Chen M, Tao H, Ali-Salaam P, Telford SR, and Flavell RA (1994). Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J Infect Dis 169:568-574.
25. Fikrig E, Telford SR III, Barthold SW, Kantor FS, Spielman A, and Flavell RA (1992b). Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci USA 89:5418-5421.
26. Frazer DD, King LI, and Miller FW (1992). Molecular detection of persistent Borrelia burgdorferi in a man with dermatomyositis. Clin Exp Rheumatol 10:387-390.
27. Gern L, Schaible UE, and Simon MM (1993). Mode of inoculation of the Lyme disease agent Borrelia burgdorferi influences infection and immune responses in inbred strains of mice. J Infect Dis 167:971-975.
28. Golde WT, Kappel KJ, Dequesne G, Feron C, Plainchamp D, Capiau C, and Lobet Y (1994). Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P 1994;39 but not to outer surface protein A. Infect Immun 62:2625-2627.
29. Haupl T, Hahn G, Rittig M, Krause A, Schoerner C, Schonherr U, Kalden JR, and Burmester GR (1993). Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Arthritis Rheum 36:1621-1626.
30. Hendrickson EA (1993). The SCID mouse: Relevance as an animal model system for studying human disease. Am J Pathol 143:1511-1522.
31. Hovmark A, Asbrink E, and Olsson I (1986). The spirochetal etiology of lymphadenosis benigna cutis solitaria. Acta Derm Venereol (Stockh) 66:479-484.
32. Johnson RC, Kodner C, and Russell M (1986). Passive immunization of hamsters against experimental infection with Borrelia burgdorferi. Infect Immun 53:713-716.
33. Johnson RC, Kodner C, Russell M, and Duray PH (1988). Experimental infection of hamsters with Borrelia burgdorferi. Ann NY Acad Sci 539:258-263.
34. Kalish R, Leong JM, and Steere AC (1993). Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect Immun 61:2774-2779.
35. Keane-Myers A and Nickell SP (1995). T cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice. J Immunol 154:1770-1776.
36. Leigner KB, Shapiro JR, Ramsey D, Halperin AJ, Hogrefe W, and Kong L (1993). Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection. J Am Acad Dermatol 28:312-314.
37. Lim L, England D, DuChateau B, Glowacki N, and Schell R (1995). Borrelia burgdorferi-specific T lymphocytes induce severe destructive Lyme arthritis. Infect Immun 63:1400-1408.
38. Lovrich SD, Callister SM, Schmitz JL, Alder JF, and Schell RF (1991). Borreliacidal activity of sera from hamsters infected with the Lyme disease spirochete. Infect Immun 59:2522-2528.
39. Matyniak JE and Reiner SL (1995). T helper phenotype and genetic susceptibility in experimental Lyme disease. J Exp Med 181:1251-1254.
40. Moody KD, Adams RL, and Barthold SW (1994). Effectiveness of antimicrobial treatment against Borrelia burgdorferi infection in mice. Antimicrob Agents Chemother 38:1567-1572.
41. Nadelman RB, Pavia CS, Magnarelli LA, and Wormser GP (1990). Isolation of Borrelia burgdorferi from the blood of seven patients with Lyme disease. Am J Med 88:21-26.
42. Nocton JJ, Dressler F, Rutledge RJ, Rys PN, Persing DH, and Steere AC (1994). Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med 330:229-234.
43. NortonHughes CA, Engstrom SM, Coleman LA, Kodner CB, and Johnson RC (1993). Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB. Infect Immun 61:5115-5122.
44. Preac-Mursic V, Pfister HW, Wilske B, Gross B, Baumann A, and Prokop J (1989). Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infection 17:355-359.
45. Preac-Mursic V, Wilske B, Schierz G, Pfister HW, and Einhaupl K (1984). Repeated isolation of spirochetes from the cerebrospinal fluid of a patient with meningoradiculitis Bannwarth. Eur J Clin Microbiol 3:564-565.
46. Randazzo JP, DiSpaltro FX, Cottrill C, Klainer AS, Steere AC, and Bisaccia E (1994). Successful treatment of a patient with chronic Lyme arthritis with extracorporeal photochemotherapy. J Am Acad Dermatol 30:908-910.
47. Rao TD, Fischer A, and Frey AB (1994). CD4+Th-2 cells elicited by immunization confer protective immunity to experimental Borrelia burgdorferi infection. Ann NY Acad Sci 730:364-366.
48. Schaible UE, Gern L, Wallich R, Kramer MD, Prester M, and Simon MM (1993a). Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen. Immunol Lett 36:219-226.
49. Schaible UE, Kramer MD, Eichmann K, Modolell M, Museteanu C, and Simon MM (1990a). Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci USA 87:3768-3772.
50. Schaible UE, Kramer MD, Justus CWE, Musteanu C, and Simon MM (1989b). Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi. Infect Immun 57:41-47.
51. Schaible UE, Kramer MD, Museteanu C, Zimmer G, Mossman H, and Simon MM (1989a). The severe combined immunodeficient mouse: A laboratory model for the analysis of Lyme arthritis and carditis. J Exp Med 170:1427-1432.
52. Schaible UE, Kramer MD, Museteanu C, Zimmer G, Mossmann H, and Simon MM (1990b). Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart and liver. Am J Pathol 137:811-820.
53. Schaible UE, Wallich R, Kramer MD, Gern L, Anderson JF, Museteanu C, and Simon MM (1993b). Immune sera to individual Borrelia burgdorferi isolates or recombinant OspA thereof protect SCID mice against infection with homologous strains but only partially or not at all against those of different OspA/OspB genotype. Vaccine 11:1049-1054.
54. Schaible UE, Wallich R, Kramer MD, Nerz G, Stehle T, Museteanu C, and Simon MM (1994). Protection against Borrelia burgdorferi infection in SCID mice is conferred by presenstized spleen cells and partially by B but not T-cells alone. Int Immunol 6:671-681.
55. Schmidli J, Hunziker T, Moesli P, and Schaad UB (1988). Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to Lyme borreliosis. J Infect Dis 158:905-906.
56. Schmitz JL, Schell RF, Hejka AG, and England DM (1990). Passive immunization prevents induction of Lyme arthritis in LSH hamsters. Infect Immun 58:144-148.
57. Schwan TG, Piesman J, Golde W, Dolan M, and Rosa P (1995). Induction of outer surface protein on Borrelia burgdorferi during tick-feeding. Proc Natl Acad Sci USA 92:2909-2913.
58. Simon MM, Schaible UE, Kramer MD, Eckerskorn C, Museteanu C, Muller-Hermelink HK, and Wallich R (1991a). Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J Infect Dis 164:123-132.
59. Simon MM, Schaible UE, Wallich R, and Kramer MD (1991b). A mouse model for Borrelia burgdorferi infection: Approach to a vaccine against Lyme disease. Immunol Today 12:11-16.
60. Snydman DR, Schenkein DP, Berardi VP, Lastavica CC, and Pariser KM (1986). Borrelia burgdorferi in joint fluid in chronic Lyme arthritis. Ann Intern Med 104:798-800.
61. Stanek G, Klein J, Bittner R, and Glogar D (1990). Isolation of Borrelia burgdorferi from the myocardium of a patient with longstanding cardiomyopathy. N Engl J Med 322:249-252.
62. Steere AC (1989). Lyme disease. N Engl J Med 321:586-596.
63. Suk K, Das S, Sun W, Jwang B, Barthold SW, Flavell RA, and Fikrig E (1995). Borrelia burgdorferi genes selectively expressed in the infected host. Proc Natl Acad Sci USA 92:4269-4276.
64. Telford SR, Kantor FS, Lobet Y, Barthold SW, Spielman A, Flavell RA, and Fikrig E (1995). Efficacy of human Lyme disease vaccine formulations in a mouse model. J Infect Dis 171:1368-1370.