Dissociation of infectivity and pathogenicity in Borrelia burgdorferi

Infection and Immunity

Volumn 69, Issue 5, 2001, Pages 3507-3509

  Thomas, V ^a   Anguita, J ^a   Samanta, S ^a   Rosa, P A ^a   Stewart, P ^a   Barthold, S W ^a   Fikrig, E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; BORRELIA BURGDORFERI; BORRELIA INFECTION; GENOTYPE; INFECTION; NONHUMAN; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BORRELIA BURGDORFERI GROUP; DISEASE MODELS, ANIMAL; LYME DISEASE; MICE; MICE, INBRED C3H; PLASMIDS;

EID: 0035064038     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.5.3507-3509.2001     Document Type: Article

References (34)

1. Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity
2. Lyme borreliosis in selected strains and ages of laboratory mice
3. Kinetics of Borrelia burgdorferi: Dissemination and evolution of disease following intradermal inoculation of mice
4. Efficiennt targeted mutagenesis in Borrelia burgdorferi
5. Membrane protein variations associated with in vitro passage of Borrelia burgdorferi
6. Plasminogen is required for efficient dissemination of Borrelia burgdorferi in ticks and for enhancement of spirochetemia in mice
7. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host
8. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine
9. Altered stationary-phase response in a Borrelia burgdorferi rpoS mutant
10. Lyme arthritis resolution with antiserum to a 37-kilodalton Borrelia burgdorferi protein
11. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity
12. Borrelia burgdorferi erpT expression in the arthropod vector and murine host
13. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
14. Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1
15. Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: Evidence for lateral gene exchange
16. Relationship between infectivity and OspC expression in Lyme disease Borrelia
17. Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions
18. Lyme borreliosis
19. Low-passage-associated proteins of Borrelia burgdorferi B31: Characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein
20. High- and low-infectivity phenotypes of clonal populations of in vitro-cultured Borrelia burgdorferi
21. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB or OspC but not OspD or the 83-kilodalton antigen
22. Correlation between plasmid content and infectivity in Borrelia burgdorferi
23. Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi
24. An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo
25. Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation
26. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
27. Immunity to Lyme disease: Protection, pathology and persistence
28. Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi
29. Transformation of the Lyme disease spirochete Borrelia burgdorferi with heterologous DNA
30. Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi
31. Correlation of plasmids with infectivity of Borrelia burgdorferi sensu stricto type strain B31
32. Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi
33. Antigenic variation in Lyme disease borreliae by promiscuous recombination of Vmp-like sequence cassettes
34. Kinetics and in vivo induction of genetic variation of vise in Borrelia burgdorferi