Plasma levels of soluble CD14 and tumor necrosis factor-α type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection

Journal of Infectious Diseases

Volumn 184, Issue 6, 2001, Pages 699-706

  Ryan, Lisa A ^a,b   Zheng, Jialin ^a,b   Brester, Michelle ^a   Bohac, Daryl ^b   Hahn, Francis ^a   Anderson, James ^b   Ratanasuwan, Winai ^a,b   Gendelman, Howard E ^a,b   Swindells, Susan ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD14 ANTIGEN; CHOLINE; CREATININE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; APTITUDE TEST; ARTICLE; BRAIN ATROPHY; CLINICAL ARTICLE; COGNITIVE DEFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MALE; NEUROPATHOLOGY; PRIORITY JOURNAL; VIRUS LOAD;

ADULT; AFRICAN AMERICANS; AFRICAN CONTINENTAL ANCESTRY GROUP; ANTIGENS, CD; ANTIGENS, CD14; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ATROPHY; BIOLOGICAL MARKERS; BRAIN; COGNITION DISORDERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LEARNING; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED; NEBRASKA; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; REGRESSION ANALYSIS; RNA, VIRAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035884444     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/323036     Document Type: Article

References (65)

1. HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990-1998
2. Human immunodeficiency virus-associated dementia
3. Predicting clinical progression or death in subjects with early stage HIV infection: A comparative analysis of quantification of HIV RNA, soluble tumor necrosis factor type II receptors, neopterin and B2-microglobulin
4. Platelet-activating factor: A candidate human immunodeficiency virus type-1 infection neurotoxin
5. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: Relationship to clinical and neurological status
6. Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment
7. Proton MR spectroscopy of HIV-infected patients: Characterization of abnormalities with imaging and clinical correlation
8. Brain choline containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex
9. Metabolite changes in the basal ganglia provide a signature for the Al DS dementia complex: A multi-center proton magnetic resonance study
10. Proton MRS and neuropsychological assessments in AIDS dementia complex: A measure of subcortical function
11. Dementia in AIDS patients: Incidence and risk factors. Multicenter AIDS Cohort Study
12. Asymptomatic and neurologically symptomatic HIV-seropositive subjects: Results of long-term MR imaging and clinical follow-up
13. Magnetic resonance abnormalities in HIV infection: A study in the drug-user risk group
14. Proton spectroscopy of the brain in HIV infection: Correlation with clinical, immunologic, and MR imaging findings
15. Proton spectroscopy in asymptomatic HIV-in fected adults: Initial results in a prospective cohort study
16. Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients
17. Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta
18. HIV infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism
19. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia
20. Infection of human fetal astrocytes with HIV-1: Viral tropism and the role of cell to cell contact in viral transmission
21. Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope protein gp120 on human fetal astrocytes
22. HIV-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise
23. Unique monocyte subset in patients with AIDS dementia
24. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia
25. Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection - Correlations to clinical, immunologic, and virologic parameters
26. Soluble receptors for tumor necrosis factor as predictors of progression to AIDS in asymptomatic human immunodeficiency virus type 1 infection
27. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements
28. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo
29. A mechanism of TNFR type II (75 kDa) "shedding" in macrophages
30. Stabilization of the bioactivity of tumor necrosis factor and its soluble receptors
31. HIV-1 induces turnout necrosis factor and IL-1 gene expression in primary human macrophages independent of productive infection
32. Human monocyte CD14 is upregulated by lipopolysaccharide
33. Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: Correlation to disease progression and clinical events
34. Increased soluble CD14 serum levels and altered CD14 expression of peripheral blood monocytes in HIV-infected patients
35. HIV neurocognitive disorders
36. Partington's pathway test
37. Stroop Test
38. Grooved Pegboard Test
39. Cytokines and HIV infection: Is AIDS a tumor necrosis factor disease?
40. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line
41. Cytokine expression in the brain during acquired immune deficiency syndrome
42. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia
43. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes
44. Utility of cerebral proton magnetic resonance spectroscopy in differential diagnosis of HIV-related dementia
45. Brain proton magnetic resonance spectroscopy in HIV-related encephalopathy: Identification of evolving metabolic patterns in relation to dementia and therapy
46. Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society - USA Panel
47. Impact of highly active anti-retroviral therapy (HAART) on cytokine production and monocyte subsets in HIV-infected patients
48. Evolution of plasma levels of soluble interleukin-2 (sIL2-R) and tumor necrosis factor type II (sTNFII-R) receptors is correlated with immunologic or virologic responses of patients treated by protease inhibitor-containing regimen
49. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
50. Human immunodeficiency virus-associated dementia
51. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy
52. Early viral brain invasion in iatrogenic human immunodeficiency virus infection
53. The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection
54. Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS
55. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
56. Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: Evidence for monocyte trafficking into brain
57. Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain
58. HIV infection and dementia
59. The HIV-1 associated dementia complex: A metabolic encephalopathy fueled by viral replication in mononuclear phagocytes
60. Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy
61. Soluble tumor necrosis factor receptor: Inhibition of human immunodeficiency virus activation