Heterozygous inactivation of TGF-β1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras

Toxicology Letters

Volumn 123, Issue 2-3, 2001, Pages 151-158

  McKenna, Ilda M ^a,d   Ramakrishna, Gayatri ^b   Diwan, Bhalchandra A ^c   Kang, Yang ^d   Shiao, Yih Horng ^b   Wakefield, Lalage M ^d   Powell, Douglas A ^b   Anderson, Lucy M ^b   Jakowlew, Sonia B ^d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

K ras mutations; Lung tumorigenesis; Transforming growth factor 1

Indexed keywords

K RAS PROTEIN; PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; URETHAN;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CODON; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVATION; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENOTYPE; GROWTH INHIBITION; HETEROZYGOSITY; LUNG CARCINOGENESIS; LUNG TUMOR; MOUSE; MUTATION RATE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTO ONCOGENE; SINGLE STRAND CONFORMATION POLYMORPHISM; STRAIN DIFFERENCE;

ADENOMA; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CARCINOMA; CROSSES, GENETIC; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MUTAGENICITY TESTS; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; URETHANE;

ANIMALIA;

EID: 0035883715     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00393-9     Document Type: Article

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