Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

EMBO Journal

Volumn 19, Issue 21, 2000, Pages 5813-5823

  Beier, Rudolf ^a   Bürgin, Andrea ^a   Kiermaier, Astrid ^a   Fero, Matthew ^b   Karsunky, Holger ^c   Saffrich, Rainer ^d   Möröy, Tarik ^c   Ansorge, Wilhelm ^d   Roberts, Jim ^b   Eilers, Martin ^a  

^a Institute of Molecular Biology and Tumour Research   (Germany)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

c Myc; Cell growth; Cyclin E kinase; E2F2; p27

Indexed keywords

BROXURIDINE; CYCLIN D2; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PROTEIN P27; TRANSCRIPTION FACTOR E2F;

ARTICLE; CELL CYCLE S PHASE; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; ENZYME REGULATION; FIBROBLAST; ONCOGENE C MYC; PRIORITY JOURNAL; RETROVIRUS; SIGNAL TRANSDUCTION;

EID: 0034329386     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.21.5813     Document Type: Article

References (50)

1. 1 phase by specific inhibition of CDK2 kinase activity
2. Myc and the cell cycle
3. 1 arrest through reduction of cyclin E/CDK2 kinase activity
4. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
5. Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
6. Requirement of p27(Kip1) for restriction point control of the fibroblast cell cycle
7. A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells
8. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signalling and adhesion
9. c-Myc target genes involved in cell growth, apoptosis and metabolism
10. Chimaeras between the MYC oncoprotein and steroid receptors cause hormone-dependent transformation of cells
11. The MYC protein activates transcription of the α-prothymosin gene
12. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis and female sterility in p27(Kip1)-deficient mice
13. Cdc25 cell-cycle phosphatase as a target of c-myc
14. Myc induces the nucleolin and BN51 genes: Possible implications in ribosome biogenesis
15. High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein
16. 1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers
17. Mutual requirement of CDK4 and Myc in malignant transformation: Evidence for cyclin D1/CDK4 and p16(INK4A) as upstream regulators of Myc
18. Identification of c-MYC as a target of the APC pathway
19. Identification of CDK4 as a target of c-MYC
20. c-Myc enhances protein synthesis and cell size during B lymphocyte development
21. Differential modulation of cyclin gene expression by MYC
22. Novel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (eIF4E) and their function in growth regulation
23. Drosophila myc regulates cellular growth during development
24. 1 and S phases of the mammalian cell cycle
25. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
26. 1 cyclin dependent kinase activity in the induction of S phase
27. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
28. 1 phase progression in specific cell types
29. Cyclin E-induced S phase without activation of the pRb/E2F pathway
30. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
31. c-Myc regulates cyclin D-cdk4 and -cdk6 activity but affects cell cycle progression at multiple independent points
32. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells
33. Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes
34. Coordination of growth and cell division in the Drosophila wing
35. Mysterious liaisons: The relationship between c-Myc and the cell cycle
36. Gene-target recognition among members of the myc superfamily and implications for oncogenesis
37. Myc-enhanced expression of Cull promotes ubiquitin-dependent proteolysis and cell cycle progression
38. Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1)
39. Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
40. 1-cyclin-dependent kinases
41. Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2α in response to growth induction by c-myc
42. Activation of cyclin dependent kinases by Myc mediates transcriptional activation of cyclin A, but not apoptosis
43. 1/S-promoting mechanism parallel to the pRb/E2F pathway
44. Control of cell growth by c-Myc in the absence of cell division
45. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
46. Ras enhances Myc protein stability
47. 1 cyclin/cdk complexes
48. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
49. Growth arrest by the cyclin-dependent kinase inhibitor p27(Kip1) is abrogated by c-Myc
50. 1 arrest pathway