The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas

Cancer Research

Volumn 61, Issue 16, 2001, Pages 6008-6011

  Polsky, David ^b   Young, Alison Zuyung ^b   Busam, Klaus J ^b   Alani, Rhoda M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; PROTEIN P16; TRANSCRIPTION FACTOR;

ARTICLE; CANCER STAGING; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL GROWTH; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MELANOMA; METASTASIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TRANSACTIVATION; TRANSCRIPTION REGULATION;

CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; MELANOMA; NEOPLASM STAGING; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0035881619     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
2. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
3. Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1
4. Id-1 delays senescence but does not immortalize keratinocytes
5. Genes involved in senescence and immortalization
6. Creation of human tumour cells with defined genetic elements
7. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
8. The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts
9. Opposing effects of Ets and ld proteins on p16Ink4a expression during cellular senescence
10. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
11. Cancer cell cycles
12. Regulation of transcription by proteins that control the cell cycle
13. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
14. Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis
15. Germline p16 mutations in familial melanoma
16. Role of the p16 tumor suppressor gene in cancer
17. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression
18. p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma
19. Hereditary cutaneous melanoma
20. An analysis of p16 protein expression in sporadic malignant melanoma
21. p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma
22. Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth
23. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis