메뉴 건너뛰기




Volumn 269, Issue 2, 2000, Pages 404-419

While E1A can facilitate epithelial cell transformation by several dominant oncogenes, the C-terminus seems only to regulate rac and cdc42 function, but in both epithelial and fibroblastic cells

Author keywords

Actin; GTPases; Mos; Raf; Ras; Src

Indexed keywords

ACTIN; CELL CYCLE PROTEIN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; RAC PROTEIN; RAF PROTEIN; RAS PROTEIN;

EID: 0034630321     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0232     Document Type: Article
Times cited : (15)

References (65)
  • 1
    • 0028876839 scopus 로고
    • A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
    • Arany Z., Newsome D., Oldread E., Livingston D. M., Eckner R. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature. 374:1995;81-84.
    • (1995) Nature , vol.374 , pp. 81-84
    • Arany, Z.1    Newsome, D.2    Oldread, E.3    Livingston, D.M.4    Eckner, R.5
  • 2
    • 0027971147 scopus 로고
    • Adenovirus E1A proteins and transformation
    • Bayley S. T., Mymryk J. S. Adenovirus E1A proteins and transformation. Int. J. Oncol. 5:1994;325-444.
    • (1994) Int. J. Oncol. , vol.5 , pp. 325-444
    • Bayley, S.T.1    Mymryk, J.S.2
  • 4
    • 0029066824 scopus 로고
    • Adherens junction proteins in tumor progression
    • Birchmeier W., Hulsken J., Behrens J. Adherens junction proteins in tumor progression. Cancer Surveys. 24:1995;129-140.
    • (1995) Cancer Surveys , vol.24 , pp. 129-140
    • Birchmeier, W.1    Hulsken, J.2    Behrens, J.3
  • 5
    • 0019308627 scopus 로고
    • Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency
    • Blaire D. G., McClements W. L., Oskarsson M. K., Fischinger P. J., Vande Woude G. F. Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency. Proc. Natl. Acad. Sci. USA. 77:1980;3504-3508.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 3504-3508
    • Blaire, D.G.1    McClements, W.L.2    Oskarsson, M.K.3    Fischinger, P.J.4    Vande Woude, G.F.5
  • 6
    • 0027232605 scopus 로고
    • Emerging concepts in the Ras superfamily of GTP-binding proteins
    • Bokoch G. M., Der C. J. Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J. 7:1993;750-759.
    • (1993) FASEB J. , vol.7 , pp. 750-759
    • Bokoch, G.M.1    Der, C.J.2
  • 7
    • 0027509346 scopus 로고
    • A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
    • Boyd J. M., Subramanian T., Schaeper U., La Regina M., Bayley S., Chinnadurai G. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J. 12:1993;469-478.
    • (1993) EMBO J. , vol.12 , pp. 469-478
    • Boyd, J.M.1    Subramanian, T.2    Schaeper, U.3    La Regina, M.4    Bayley, S.5    Chinnadurai, G.6
  • 8
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells
    • Cowley S., Paterson H., Kemp P., Marshall C. J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells. Cell. 77:1994;841-852.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 10
    • 0025936354 scopus 로고
    • Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A 12S gene
    • Douglas J. L., Gopalakrishnan S., Quinlan M. P. Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A 12S gene. Oncogene. 6:1991;2093-2103.
    • (1991) Oncogene , vol.6 , pp. 2093-2103
    • Douglas, J.L.1    Gopalakrishnan, S.2    Quinlan, M.P.3
  • 11
    • 0028120365 scopus 로고
    • Efficient nuclear localization of the Ad5 E1A 12S protein is necessary for immortalization but not cotransformation of primary epithelial cells
    • Douglas J. L., Quinlan M. P. Efficient nuclear localization of the Ad5 E1A 12S protein is necessary for immortalization but not cotransformation of primary epithelial cells. Cell Growth Differ. 5:1994;475-483.
    • (1994) Cell Growth Differ. , vol.5 , pp. 475-483
    • Douglas, J.L.1    Quinlan, M.P.2
  • 12
    • 0028788031 scopus 로고
    • Efficient nuclear localization and immortalizing ability, two functions dependent on the Ad5 E1A second exon, are necessary for cotransformation with Ad5 E1B, but not T24 ras
    • Douglas J. L., Quinlan M. P. Efficient nuclear localization and immortalizing ability, two functions dependent on the Ad5 E1A second exon, are necessary for cotransformation with Ad5 E1B, but not T24 ras. J. Virol. 69:1995;8061-8065.
    • (1995) J. Virol. , vol.69 , pp. 8061-8065
    • Douglas, J.L.1    Quinlan, M.P.2
  • 13
    • 0024515741 scopus 로고
    • Binding of the RB1 protein to E1A products is required for adenovirus transformation
    • Egan C., Bayley S. T., Branton P. E. Binding of the RB1 protein to E1A products is required for adenovirus transformation. Oncogene. 4:1989;383-388.
    • (1989) Oncogene , vol.4 , pp. 383-388
    • Egan, C.1    Bayley, S.T.2    Branton, P.E.3
  • 14
    • 0023261614 scopus 로고
    • Transformation by oncogenes encoding protein kinases induces the metastatic phenotype
    • Egan S. E., Wright J. A., Jarolim L., Yanagihara K., Bassin R. H., Greenberg A. H. Transformation by oncogenes encoding protein kinases induces the metastatic phenotype. Science. 238:1987;202-204.
    • (1987) Science , vol.238 , pp. 202-204
    • Egan, S.E.1    Wright, J.A.2    Jarolim, L.3    Yanagihara, K.4    Bassin, R.H.5    Greenberg, A.H.6
  • 15
    • 0027460263 scopus 로고
    • The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2
    • Faha B., Harlow E., Lees E. The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J. Virol. 67:1993;2456-2465.
    • (1993) J. Virol. , vol.67 , pp. 2456-2465
    • Faha, B.1    Harlow, E.2    Lees, E.3
  • 16
    • 0032581941 scopus 로고    scopus 로고
    • The C-terminus of E1A regulates tumor progression and epithelial cell differentiation
    • Fischer R. S., Quinlan M. P. The C-terminus of E1A regulates tumor progression and epithelial cell differentiation. Virology. 249:1998a;427-439.
    • (1998) Virology , vol.249 , pp. 427-439
    • Fischer, R.S.1    Quinlan, M.P.2
  • 17
    • 0031949105 scopus 로고    scopus 로고
    • Expression of the Rb binding regions of E1A enables efficient transformation of primary epithelial cells by v-src
    • Fischer R. S., Quinlan M. P. Expression of the Rb binding regions of E1A enables efficient transformation of primary epithelial cells by v-src. J. Virol. 72:1998b;2815-2824.
    • (1998) J. Virol. , vol.72 , pp. 2815-2824
    • Fischer, R.S.1    Quinlan, M.P.2
  • 18
    • 0031734679 scopus 로고    scopus 로고
    • Identification of a novel mechanism of regulating the adherens junction by E1A, Rac1 and CAFs, which contributes to tumor progression
    • Fischer R. S., Quinlan M. P. Identification of a novel mechanism of regulating the adherens junction by E1A, Rac1 and CAFs, which contributes to tumor progression. Cell Growth Differ. 9:1998c;905-918.
    • (1998) Cell Growth Differ. , vol.9 , pp. 905-918
    • Fischer, R.S.1    Quinlan, M.P.2
  • 19
    • 0031928106 scopus 로고    scopus 로고
    • Rac1 and extracellularly regulated kinase activation are sufficient for E1A-dependent cooperative transformation of primary epithelial cells, but progression can only be modulated by E1A or Rac1
    • Fischer R. S., Zheng Y., Quinlan M. P. Rac1 and extracellularly regulated kinase activation are sufficient for E1A-dependent cooperative transformation of primary epithelial cells, but progression can only be modulated by E1A or Rac1. Cell Growth Differ. 9:1998;209-221.
    • (1998) Cell Growth Differ. , vol.9 , pp. 209-221
    • Fischer, R.S.1    Zheng, Y.2    Quinlan, M.P.3
  • 20
    • 0030955636 scopus 로고    scopus 로고
    • Immortalization of primary epithelial cells by E1A 12S requires late, second exon-encoded functions in addition to complex formation with pRb and p300
    • Gopalakrishnan S., Douglas J. L., Quinlan M. P. Immortalization of primary epithelial cells by E1A 12S requires late, second exon-encoded functions in addition to complex formation with pRb and p300. Cell Growth Differ. 8:1997;541-551.
    • (1997) Cell Growth Differ. , vol.8 , pp. 541-551
    • Gopalakrishnan, S.1    Douglas, J.L.2    Quinlan, M.P.3
  • 21
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science. 279:1998;509-513.
    • (1998) Science , vol.279 , pp. 509-513
    • Hall, A.1
  • 22
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • Hay E. D. An overview of epithelio-mesenchymal transformation. Acta Anat. 154:1995;8-20.
    • (1995) Acta Anat. , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 24
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu Q., Kippel A., Muslin A. J., Fantl W. J., Williams L. T. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science. 268:1995;100-102.
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Kippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5
  • 25
    • 0030933277 scopus 로고    scopus 로고
    • Oncoprotein networks
    • Hunter T. Oncoprotein networks. Cell. 88:1997;333-346.
    • (1997) Cell , vol.88 , pp. 333-346
    • Hunter, T.1
  • 26
    • 0024353625 scopus 로고
    • Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer and induction of proliferating cell nuclear antigen
    • Jelsma T. N., Howe J. A., Mymrk J. S., Evelegh C. M., Cuniff N. F. A., Bayley S. T. Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer and induction of proliferating cell nuclear antigen. Virology. 171:1989;120-130.
    • (1989) Virology , vol.171 , pp. 120-130
    • Jelsma, T.N.1    Howe, J.A.2    Mymrk, J.S.3    Evelegh, C.M.4    Cuniff, N.F.A.5    Bayley, S.T.6
  • 27
    • 0030222341 scopus 로고    scopus 로고
    • Crosstalk between cell adhesion molecules: Vinculin as a paradigm for regulation by conformation
    • Jockusch B. M., Rudiger M. Crosstalk between cell adhesion molecules: Vinculin as a paradigm for regulation by conformation. Trends Cell Biol. 6:1996;311-315.
    • (1996) Trends Cell Biol. , vol.6 , pp. 311-315
    • Jockusch, B.M.1    Rudiger, M.2
  • 28
    • 0030771387 scopus 로고    scopus 로고
    • Ras effectors and their role in mitogenesis and oncogenesis
    • Joneson T., Bar-Sagi D. Ras effectors and their role in mitogenesis and oncogenesis. J. Mol. Med. 75:1997;587-593.
    • (1997) J. Mol. Med. , vol.75 , pp. 587-593
    • Joneson, T.1    Bar-Sagi, D.2
  • 29
    • 0028800305 scopus 로고
    • Activation of rac1, rhoA, and mitogen-activated protein kinases is required for ras transformation
    • Khosravi-Far R., Solski P. A., Clark G. J., Kinch M. S., Der C. J. Activation of rac1, rhoA, and mitogen-activated protein kinases is required for ras transformation. Mol. Cell. Biol. 15:1995;6443-6453.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 30
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel A., Reinhard C., Kavanaugh W. M., Apell G., Escobedo M. A., Williams L. T. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16:1996;4117-4127.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.A.5    Williams, L.T.6
  • 31
    • 0023934299 scopus 로고
    • Cell type dependent transformation by adenovirus 5 E1A proteins
    • Kuppuswamy M., Chinnadurai G. Cell type dependent transformation by adenovirus 5 E1A proteins. Oncogene. 2:1988;567-572.
    • (1988) Oncogene , vol.2 , pp. 567-572
    • Kuppuswamy, M.1    Chinnadurai, G.2
  • 32
    • 0026577380 scopus 로고
    • Enhanced invasive properties of rat embryo fibroblasts transformed by adenovirus E1A mutants with deletions in the carboxy-terminal exon
    • Linder S., Popowicz P., Svensson C., Marshall H., Bondesson M., Akusjarvi G. Enhanced invasive properties of rat embryo fibroblasts transformed by adenovirus E1A mutants with deletions in the carboxy-terminal exon. Oncogene. 7:1992;439-443.
    • (1992) Oncogene , vol.7 , pp. 439-443
    • Linder, S.1    Popowicz, P.2    Svensson, C.3    Marshall, H.4    Bondesson, M.5    Akusjarvi, G.6
  • 33
    • 0032955274 scopus 로고    scopus 로고
    • Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein
    • Liu K., Li L., Nisson P. E., Gruber C., Jessee J., Cohen S. N. Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein. Mol. Cell. Biol. 19:1999;3696-3703.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3696-3703
    • Liu, K.1    Li, L.2    Nisson, P.E.3    Gruber, C.4    Jessee, J.5    Cohen, S.N.6
  • 34
    • 0024209357 scopus 로고
    • Cooperative transforming activities of ras, myc, and src viral oncogenes in nonestablished rat adrenocortical cells
    • MacAuley A., Pawson T. Cooperative transforming activities of ras, myc, and src viral oncogenes in nonestablished rat adrenocortical cells. J. Virol. 62:1988;4712-4721.
    • (1988) J. Virol. , vol.62 , pp. 4712-4721
    • MacAuley, A.1    Pawson, T.2
  • 38
    • 0032516847 scopus 로고    scopus 로고
    • Structural determinant present in the C-terminal binding protein binding site of adenovirus early region 1A proteins
    • Molloy D. P., Milner A. E., Yakub I. K., Chinnadurai G., Gallimore P. H., Grand R. J. Structural determinant present in the C-terminal binding protein binding site of adenovirus early region 1A proteins. J. Biol. Chem. 273:1998;20867-20876.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20867-20876
    • Molloy, D.P.1    Milner, A.E.2    Yakub, I.K.3    Chinnadurai, G.4    Gallimore, P.H.5    Grand, R.J.6
  • 39
    • 0029985110 scopus 로고    scopus 로고
    • Tumour suppressive properties of the adenovirus 5 E1A oncogene
    • Mymryk J. S. Tumour suppressive properties of the adenovirus 5 E1A oncogene. Oncogene. 13:1996;1581-1589.
    • (1996) Oncogene , vol.13 , pp. 1581-1589
    • Mymryk, J.S.1
  • 40
    • 0029094097 scopus 로고
    • Adenovirus E1A: Transcription regulation and alteration of cell growth control
    • Nevins J. R. Adenovirus E1A: Transcription regulation and alteration of cell growth control. Curr. Top. Microbiol. Immunol. 199:1995;131-148.
    • (1995) Curr. Top. Microbiol. Immunol. , vol.199 , pp. 131-148
    • Nevins, J.R.1
  • 41
    • 0032478737 scopus 로고    scopus 로고
    • Interaction of short-range repressors with Drosophila CtBp in the embryo
    • Nibu Y., Zhang H., Levine M. Interaction of short-range repressors with Drosophila CtBp in the embryo. Science. 280:1998;101-104.
    • (1998) Science , vol.280 , pp. 101-104
    • Nibu, Y.1    Zhang, H.2    Levine, M.3
  • 42
    • 0032559211 scopus 로고    scopus 로고
    • Coupling of ras and rac guanine triphosphatases through the ras exchanger sos
    • Nimnual A. S., Yatsula B. A., Bar-Sagi D. Coupling of ras and rac guanine triphosphatases through the ras exchanger sos. Science. 279:1998;560-563.
    • (1998) Science , vol.279 , pp. 560-563
    • Nimnual, A.S.1    Yatsula, B.A.2    Bar-Sagi, D.3
  • 43
    • 0029959434 scopus 로고    scopus 로고
    • Activation of the Raf-1/MAP kinase cascade is not sufficient for ras transformation of RIE-1 epithelial cells
    • Oldham S. M., Clark G. J., Gangarosa L. M., Coffey R. J., Der C. J. Activation of the Raf-1/MAP kinase cascade is not sufficient for ras transformation of RIE-1 epithelial cells. Proc. Natl. Acad. Sci. USA. 93:1996;6924-6928.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6924-6928
    • Oldham, S.M.1    Clark, G.J.2    Gangarosa, L.M.3    Coffey, R.J.4    Der, C.J.5
  • 44
    • 0032055490 scopus 로고    scopus 로고
    • Drosophila CtBP: A hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
    • Poortinga G., Watanabe M., Parkhurst S. M. Drosophila CtBP: A hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J. 17:1998;2067-2078.
    • (1998) EMBO J. , vol.17 , pp. 2067-2078
    • Poortinga, G.1    Watanabe, M.2    Parkhurst, S.M.3
  • 45
    • 0028903247 scopus 로고
    • An essential role for rac in ras transformation
    • Qui R.-G., Chen J., Kirn D., McCormick F., Symons M. An essential role for rac in ras transformation. Nature. 374:1995;457-459.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qui, R.-G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 46
    • 0024349511 scopus 로고
    • The Ad5 12S growth factor induces F9 cell proliferation and differentiation
    • Quinlan M. P. The Ad5 12S growth factor induces F9 cell proliferation and differentiation. Oncogene. 4:1989;1051-1055.
    • (1989) Oncogene , vol.4 , pp. 1051-1055
    • Quinlan, M.P.1
  • 47
    • 0010586912 scopus 로고
    • Immortalization of primary rat epithelial cells by the 12S gene of adenovirus
    • Quinlan M. P. Immortalization of primary rat epithelial cells by the 12S gene of adenovirus. Methods Cell Sci. 17:1995;125-135.
    • (1995) Methods Cell Sci. , vol.17 , pp. 125-135
    • Quinlan, M.P.1
  • 48
    • 0033547364 scopus 로고    scopus 로고
    • Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation
    • Quinlan M. P. Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation. Oncogene. 18:1999;6434-6442.
    • (1999) Oncogene , vol.18 , pp. 6434-6442
    • Quinlan, M.P.1
  • 49
    • 0026557712 scopus 로고
    • Immortalization of primary epithelial cells requires first and second exon functions of Ad5 12S
    • Quinlan M. P., Douglas J. L. Immortalization of primary epithelial cells requires first and second exon functions of Ad5 12S. J. Virol. 66:1992;2020-2030.
    • (1992) J. Virol. , vol.66 , pp. 2020-2030
    • Quinlan, M.P.1    Douglas, J.L.2
  • 50
    • 0023121272 scopus 로고
    • Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum
    • Quinlan M. P., Grodzicker T. Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum. J. Virol. 61:1987;673-682.
    • (1987) J. Virol. , vol.61 , pp. 673-682
    • Quinlan, M.P.1    Grodzicker, T.2
  • 51
    • 0023743073 scopus 로고
    • Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells
    • Quinlan M. P., Whyte P., Grodzicker T. Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells. Mol. Cell. Biol. 8:1988;3191-3203.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3191-3203
    • Quinlan, M.P.1    Whyte, P.2    Grodzicker, T.3
  • 53
    • 0028838348 scopus 로고
    • Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
    • Schaeper U., Boyd J. M., Verma S., Uhlmann E., Subramanian T., Chinnadurai G. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA. 92:1995;10467-10471.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10467-10471
    • Schaeper, U.1    Boyd, J.M.2    Verma, S.3    Uhlmann, E.4    Subramanian, T.5    Chinnadurai, G.6
  • 54
    • 0032502782 scopus 로고    scopus 로고
    • Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
    • Schaeper U., Subramanian T., Lim L., Boyd J. M., Chinnadurai G. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. J. Biol. Chem. 273:1998;8549-8552.
    • (1998) J. Biol. Chem. , vol.273 , pp. 8549-8552
    • Schaeper, U.1    Subramanian, T.2    Lim, L.3    Boyd, J.M.4    Chinnadurai, G.5
  • 55
    • 0025729836 scopus 로고
    • Defining the molecular mechanisms of human cell immortalization
    • Shay J. W., Wright W. E., Werbin H. Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta. 1072:1991;1-7.
    • (1991) Biochim. Biophys. Acta , vol.1072 , pp. 1-7
    • Shay, J.W.1    Wright, W.E.2    Werbin, H.3
  • 56
    • 0029901451 scopus 로고    scopus 로고
    • The CtBP binding domain in the adenovirus E1A protein controls CR-1 dependent transactivation
    • Sollerbrant K., Chinnadurai G., Svensson C. The CtBP binding domain in the adenovirus E1A protein controls CR-1 dependent transactivation. Nucleic Acids Res. 24:1996;2578-2584.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 2578-2584
    • Sollerbrant, K.1    Chinnadurai, G.2    Svensson, C.3
  • 57
    • 0024574323 scopus 로고
    • Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein
    • Subramanian T., La Regina M., Chinnadurai G. Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein. Oncogene. 4:1989;415-420.
    • (1989) Oncogene , vol.4 , pp. 415-420
    • Subramanian, T.1    La Regina, M.2    Chinnadurai, G.3
  • 58
    • 0025858522 scopus 로고
    • Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b
    • Subramanian T., Malstrom S. E., Chinnadurai G. Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b. Oncogene. 6:1991;1171-1173.
    • (1991) Oncogene , vol.6 , pp. 1171-1173
    • Subramanian, T.1    Malstrom, S.E.2    Chinnadurai, G.3
  • 59
    • 0020404981 scopus 로고
    • Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change
    • Taparowsky E., Suard Y., Fasano O., Shimuzu K., Goldfarb M., Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature. 300:1982;762-765.
    • (1982) Nature , vol.300 , pp. 762-765
    • Taparowsky, E.1    Suard, Y.2    Fasano, O.3    Shimuzu, K.4    Goldfarb, M.5    Wigler, M.6
  • 60
    • 0032167456 scopus 로고    scopus 로고
    • Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
    • Turner J., Crossley M. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 17:1998;5129-5140.
    • (1998) EMBO J. , vol.17 , pp. 5129-5140
    • Turner, J.1    Crossley, M.2
  • 61
    • 0029118603 scopus 로고
    • Wortmannin as a unique probe for an intracellular signaling protein, phosphoinositide 3-kinase
    • Ui M., Okada T., Hazeki K., Hazeki O. Wortmannin as a unique probe for an intracellular signaling protein, phosphoinositide 3-kinase. Trends Biochem. Sci. 20:1995;303-307.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 303-307
    • Ui, M.1    Okada, T.2    Hazeki, K.3    Hazeki, O.4
  • 62
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst L., D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 11:1997;2295-2322.
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 63
    • 0032971134 scopus 로고    scopus 로고
    • Actin binding proteins that change extent and rate of actin monomer-polymer distribution by different mechanisms
    • Weber A. Actin binding proteins that change extent and rate of actin monomer-polymer distribution by different mechanisms. Mol. Cell. Biochem. 190:1999;67-74.
    • (1999) Mol. Cell. Biochem. , vol.190 , pp. 67-74
    • Weber, A.1
  • 64
    • 0024968181 scopus 로고
    • Cellular targets for transformation by the adenovirus E1A proteins
    • Whyte P., Williamson N. M., Harlow E. Cellular targets for transformation by the adenovirus E1A proteins. Cell. 56:1989;67-75.
    • (1989) Cell , vol.56 , pp. 67-75
    • Whyte, P.1    Williamson, N.M.2    Harlow, E.3
  • 65
    • 0031687777 scopus 로고    scopus 로고
    • Signal transduction via Ras
    • Wittinghofer A. Signal transduction via Ras. Biol. Chem. 379:1998;933-937.
    • (1998) Biol. Chem. , vol.379 , pp. 933-937
    • Wittinghofer, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.