Polyamines regulate gap junction communication in connexin 43-expressing cells

Biochemical Journal

Volumn 357, Issue 2, 2001, Pages 489-495

  Shore, L ^a   McLean, P ^a   Gilmour, S K ^a   Hodgins, M B ^a   Finbow, M E ^a  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

Author keywords

Carcinogenesis; Keratinocytes; Ornithine decarboxylase

Indexed keywords

AMINES; ENZYMES; TISSUE;

TUMORIGENESIS;

CELLS;

CONNEXIN 43; ORNITHINE DECARBOXYLASE; PUTRESCINE; SPERMIDINE;

ARTICLE; CARCINOGENESIS; CELL COMMUNICATION; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GAP JUNCTION; HUMAN; HUMAN CELL; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BUTADIENES; CELL COMMUNICATION; CELL LINE; CELLS, CULTURED; CONNEXIN 43; CROSSES, GENETIC; EFLORNITHINE; EMBRYO; ENZYME INHIBITORS; GAP JUNCTIONS; HUMANS; KERATINOCYTES; MICE; MICE, KNOCKOUT; NITRILES; ORNITHINE DECARBOXYLASE; PUTRESCINE; RECOMBINANT PROTEINS; SKIN; SKIN PHYSIOLOGY; SPERMIDINE;

EID: 0035878705     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570489     Document Type: Article

References (50)

1. Gap junctions, electrotonic coupling, and intercellular communication
2. Metabolic interactions between animal cells through permeable intercellular junctions
3. Transmission of hormonal stimulation by cell-to-cell communication
4. Connexins, connexons, and intercellular communication
5. A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes
6. Selective transfer of endogenous metabolites through gap junctions composed of different connexins
7. Lack of intercellular communication between chemically transformed and surrounding nontransformed BALB/c 3T3 cells
8. Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of BALB/c 3T3 cells
9. Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential
10. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth
11. Gap-junction protein gene suppresses tumorigenicity
12. Role of connexin genes in growth control
13. Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes
14. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin 32
15. Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted
16. Immortalized connexin 43 knockout cell lines display a subset of biological properties associated with the transformed phenotype
17. Connexin 43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin dependent kinases
18. Positive selection of candidate tumor-suppressor genes by subtractive hybridization
19. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins
20. Changes in gap junction permeability, phosphorylation and number mediated by phorbol esters and non-phorbol ester tumor promoters in rat epithelial cells
21. The expression of gap junctional proteins during different stages of mouse skin carcinogenesis
22. Effect of diverse tumor promoters on the expression of gap-junctional proteins connexin (Cx)26, Cx31.1, and Cx43 in SENCAR mouse epidermis
23. Effects of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate on junctional communication in intact mouse skin: Persistence of homologous communication and increase of epidermal-dermal coupling
24. Changing patterns of gap junctional intercellular communication and connexin distribution in mouse epidermis and hair follicles during embryonic development
25. Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium
26. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents
27. Polyamines
28. Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles
29. Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas
30. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin
31. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous malignant conversion in transgenic skin
32. Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice
33. Role of ornithine decarboxylase in epidermal tumorigenesis
34. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness
35. Negative growth control of HeLa cells by connexin genes: Connexin species specificity
36. Cultivation of human epidermal keratinocytes in serum-free growth medium
37. Cardiac malformation in neonatal mice lacking connexin 43
38. Long-term culture of murine epidermal keratinocytes
39. Ras effectors
40. Ornithine decarboxylase expression leads to translocation and activation of protein kinase CK2 in vivo
41. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
42. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide
43. Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cells
44. Cyclic AMP modifies the cellular distribution of connexin 43 and induces a persistent increase in the junctional permeability of mouse mammary tumor cells
45. Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells
46. Epidermal polyamine profiles after multiple exposures to ultraviolet radiation
47. Hyperinduction of skin ornithine decarboxylase activity in psoriatic patients
48. The bovine papillomavirus type 4 E8 protein binds to ductin and causes loss of gap junctional intercellular communication in primary libroblasts
49. Human papillomavirus type 16 E5 protein affects cell - Cell communication in an epithelial cell line
50. Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels