Reversal by NS-7, a neuroprotective compound, of the decrease in transcription factor CREB mRNA expression in rat brain after permanent middle cerebral artery occlusion

Neuroscience Letters

Volumn 305, Issue 3, 2001, Pages 193-196

  Hirouchi, Masaaki ^a   Itoh, Yoshinori ^a   Aoki, Yasuaki ^a   Oka, Michiko ^a   Ukai, Yojiro ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

Basic fibroblast growth factor; Bcl 2; Cyclic AMP responsive element binding protein; Middle cerebral artery occlusion; MRNA expression

Indexed keywords

4 (4 FLUOROPHENYL) 2 METHYL 6 (5 PIPERIDINOPENTYLOXY)PYRIMIDINE; 4 (4 FLUOROPHENYL) 2 METHYL 6 (PIPERIDINOPENTYLOXY)PYRIMIDINE; BASIC FIBROBLAST GROWTH FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; NEUROPROTECTIVE AGENT; NEUROTROPHIN; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION; MALE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REDUCTION;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL ARTERIES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 2; MALE; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0035876565     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01852-3     Document Type: Article

References (20)

1. 2+ channel blocker NS-7: I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats
2. Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats
3. Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage
4. Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors
5. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
6. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
7. In vivo induction of inducible nitric oxide synthase by microinjection with interferon-γ and lipopolysaccharide in rat hippocampus
8. Effects of kainic acid on messenger RNA levels of IL-1β IL-6, TNFα and LIF in the rat brain
9. Reciprocal changes in the expression of neurotrophin mRNAs in target tissues and peripheral nerves of aged rats
10. The nucleotide sequence of the rat cytoplasmic beta-actin gene
11. 2+ channels involving depolarization-stimulated nitric oxide synthase activity in primary neuronal culture
12. Cyclic AMP-dependent regulation of fibroblast growth factor-2 messenger RNA levels in rat cortical astrocytes: Comparison with fibroblast growth factor-1 and ciliary neurotrophic factor
13. Blockade of voltage-sensitive sodium channels by NS-7, a novel neuroprotective compound, in the rat brain
14. Inhibition of ischemia-induced fodrin breakdown by a novel phenylpyrimidine derivative NS-7: An implication for its neuroprotective action in rats with middle cerebral artery occlusion
15. 2+ channel blocker NS-7: II. Effect on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of permanent middle cerebral artery occlusion in rats
16. Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia in rats
17. + channels by a novel phenylpyrimidine derivative NS-7, on CREB phosphorylation in focal cerebral ischemia in the rat
18. CREB phosphorylation promotes nerve cell survival
19. Is CREB a key to neuronal survival?
20. Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex