Myocardial signaling defects and impaired cardiac function of a human β2-adrenergic receptor polymorphism expressed in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 19, 1996, Pages 10483-10488

  Turki, Jamal ^a   Lorenz, John N ^a   Green, Stuart A ^a   Donnelly, Elizabeth T ^a   Jacinto, Marie ^a   Liggett, Stephen B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Adenylyl cyclase; Catecholamine; G protein; Heart failure; Mutation

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; ISOPRENALINE;

ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; HEART FAILURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSGENIC MOUSE;

ADENYLATE CYCLASE; ANIMALS; BLOOD PRESSURE; DNA PRIMERS; FEMALE; GENE EXPRESSION; HEART; HEART RATE; HUMANS; ISOLEUCINE; ISOPROTERENOL; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCARDIUM; MYOSIN HEAVY CHAINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PSEUDOPREGNANCY; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; THREONINE; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0029836349     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.19.10483     Document Type: Article

References (22)

1. Reihsaus, E., Innis, M., MacIntyre, N. & Liggett, S. B. (1993) Am. J. Resp. Cell Mol. Biol. 8, 334-339.
2. Liggett, S. B. (1995) News Physiol. Sci. 10, 265-273.
3. Kobilka, B. K., Dixon, R. A., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Sigal, I. S., Yang-Feng, T. L., Krancke, U., Caron, M. G. & Lefkowitz, R. J. (1987) Proc. Natl. Acad. Sci. USA 84, 46-50.
4. Green, S. A., Cole, G., Jacinto, M., Innis, M. & Liggett, S. B. (1993) J. Biol. Chem. 268, 23116-23121.
5. Green, S., Turki, J., Innis, M. & Liggett, S. B. (1994) Biochemistry 33, 9414-9419.
6. Bristow, M. R., Hershberger, R. E., Port, J. D., Minobe, W. & Rasmussen, R. (1988) Mol. Pharmacol. 35, 295-303.
7. Brodde, E. O., Schuler, S., Kretsch, R., Brinkmann, M., Borst, H. G., Hetzer, R., Reidemeister, J. C., Warnecke, H. & Zerkowski, H. R. (1986) J. Cardiovasc. Pharmacol. 8, 1235-1242.
8. Bristow, M. R., Ginsberg, R., Umans, V., Fowler, M., Minobe, W., Rasmusen, R., Zera, P., Menlove, R., Shah, P., Jamieson, S. & Stinson, E. B. (1986) Circ. Res. 59, 297-309.
9. Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A. & Lefkowitz, R. J. (1994) Science 264, 582-586.
10. Lorenz, J. N. & Kranias, E. (1995) Circulation 92, 1657-1658 (abstr.).
11. Green, S. & Liggett, S. B. (1994) J. Biol. Chem. 269, 26215-26219
12. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J. & Klenk, D. C. (1985) Anal. Biochem. 150, 76-85.
13. Schwinn, D. A., Leone, B., Spann, D. R., Chesnut, L. C., Page S. O., McRay, R. L. & Liggett, S. B. (1991) Circulation 84, 2559-2567.
14. Bond, R. A., Leff, P., Johnson, T. D., Milano, C. A., Rockman, H. A., McMinn, T. R., Apparsundaram, S., Hyek, M. F., Kenakin, T. P., Allen, L. F. & Lefkowitz, R. J. (1995) Nature (London) 374, 272-275.
15. Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R. A., Bond, R. A., Milano, C. A. & Lefkowitz, R. J. (1995) Science 268, 1350-1353.
16. Strader, C. D., Candelore, M. R., Hill, W. S., Sigal, I. S. & Dixon, R. A. F. (1989) J. Biol. Chem. 264, 13572-13578.
17. Green, S. A., Holt, B. D. & Liggett, S. B. (1992) Mol. Pharmacol. 41, 889-893.
18. Black, J. W., Leff, P. & Shankley, N. P. (1985) Br. J. Pharmacol. 84, 561-571.
19. Turki, J., Pak, J., Green, S., Martin, R. & Liggett, S. B. (1995) J. Clin. Invest. 95, 1635-1641.
20. Hall, I. P., Wheatley, A., Wilding, P. & Liggett, S. B. (1995) Lancet 345, 1213-1214.
21. Liggett, S. B. (1996) in The Genetics of Asthma, eds. Liggett, S. B. & Meyer, D. A. (Dekker, New York), pp. 455-478.
22. Liggett, S. B. & Raymond, J. R. (1993) in Catecholamines, ed. Bouloux, P. M. (Saunders, London), pp. 279-306.