A novel extracellular calcium sensing mechanism in voltage-gated potassium ion channels

Journal of Neuroscience

Volumn 21, Issue 12, 2001, Pages 4143-4153

  Johnson J P , Jr ^a   Balser, J R ^a   Bennett, P B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric; Calcium; HERG; Human ether go go related gene; Monod Wyman Changeux; Potassium channel gating

Indexed keywords

CALCIUM ION; GENE PRODUCT; MEMBRANE PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN HERG; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC POTENTIAL; EXTRACELLULAR SPACE; HUMAN; LIGAND BINDING; MOLECULAR INTERACTION; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; REPOLARIZATION; SIGNAL TRANSDUCTION;

EID: 0035875963     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-12-04143.2001     Document Type: Article

References (73)

1. HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives
2. Global parameter optimization for cardiac potassium channel gating models
3. The voltage sensor in voltage-dependent ion channels
4. Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation
5. Herg encodes a K+ current highly conserved in tumors of different histogenesis: A selective advantage for cancer cells
6. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels
7. Physiology and pathophysiology of the extracellular calcium-sensing receptor
8. The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
9. Voltage sensor-trapping: Enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II
10. Characterizing voltage-dependent conformational changes in the Shaker K+ channel with fluorescence
11. Structural implications of fluorescence quenching in the Shaker K+ channel
12. Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy
13. Allosteric receptors after 30 years
14. A novel role for HERG K+ channels: Spike-frequency adaptation
15. Allosteric gating of a large conductance Ca-activated K+ channel
16. Insertion of a SNS-specific tetrapeptide in S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na channel mu1 in HEK293 cells
17. A single negative charge within the pore region of a cGMP-gated channel controls rectification, Ca2+ blockage, and ionic selectivity
18. Role of individual surface charges of voltage-gated K channels
19. The action of calcium on the electrical properties of squid axons
20. Characterization of ether-a-go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments
21. Thermodynamics of the interaction of barnase and barstar: Changes in free energy versus changes in enthalpy on mutation
22. The multiple phenotypes of allosteric receptor mutants
23. Divalent cations and the activation kinetics of potassium channels in squid giant axons
24. Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels
25. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor
26. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
27. Voltage-dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca2+ and Mg2+
28. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
29. A new twist in the saga of charge movement in voltage-dependent ion channels
30. Double-mutant cycles: A powerful tool for analyzing protein structure and function
31. Allosteric voltage gating of potassium channels II: Mslo channel gating charge movement in the absence of Ca2+
32. Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs
33. Human ether-a-go-go-related gene K+ channel gating probed with extracellular Ca2+. Evidence for two distinct voltage sensors
34. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads
35. Transmembrane movement of the shaker K+ channel S4
36. Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons
37. Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels
38. Direct physical measure of conformational rearrangement underlying potassium channel gating
39. Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action
40. Role of the S3-S4 linker in Shaker potassium channel activation
41. Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA
42. On the nature of allosteric transitions: A plausible model
43. Voltage-dependent activation of ion channels
44. Cloning of genomic and complementary DNA from Shaker4, a putative potassium channel gene from Drosophila
45. Molecular kinetics of voltage-dependent Na+ channels
46. S4 mutations alter gating currents of Shaker K channels
47. Modulation of HERG potassium channels by extracellular magnesium and quinidine
48. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis
49. Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit
50. Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism
51. Surface electrostatic interactions contribute little of stability of barnase
52. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
53. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
54. Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles
55. A novel calcium-sensing domain in the BK channel
56. Mg2+ modulates voltage-dependent activation in ether-a-go-go potassium channels by binding between transmembrane segments S2 and S3
57. The inward rectification mechanism of the HERG cardiac potassium channel
58. Fast inactivation causes rectification of the IKr channel
59. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula
60. Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites
61. Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels
62. Extracellular Mg2+ modulates slow gating transitions and the opening of Drosophila ether-a-go-go potassium channels
63. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila
64. The Drosophila erg K+ channel polypeptide is encoded by the seizure locus
65. HERG, a human inward rectifier in the voltage-gated potassium channel family
66. Regulation of deactivation by an amino terminal domain in human ether-a-go-go-related gene potassium channels
67. Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes
68. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes
69. The seizure locus encodes the Drosophila homolog of the HERG potassium channel
70. A family of potassium channel genes related to eag in Drosophila and mammals
71. A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels
72. A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation