Generation of an MHC class II-restricted T cell epitope by extracellular processing of hepatitis δ antigen

Journal of Immunology

Volumn 160, Issue 11, 1998, Pages 5262-5266

  Accapezzato, Daniele ^a   Nisini, Roberto ^b   Paroli, Marino ^a   Bruno, Guglielmo ^a   Bonino, Ferruccio ^c   Houghton, Michael ^d   Barnaba, Vincenzo ^a,e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

^d NOVARTIS PHARMA AG   (Switzerland)

^e Pasteur Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; ARTICLE; DELTA AGENT HEPATITIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS ENVELOPE; VIRUS HEPATITIS;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CLONE CELLS; EPITOPES, T-LYMPHOCYTE; EXTRACELLULAR SPACE; HEPATITIS ANTIGENS; HEPATITIS DELTA ANTIGENS; HEPATITIS DELTA VIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTRACELLULAR FLUID; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES; TRYPSIN;

EID: 0032103935     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. + surface phenotype and a T helper 1 profile of cytokine secretion in the liver of patients chronically infected with hepatitis B virus. J. Immunol. 152: 3074.
2. + T-cell-deficient mice. J. Virol. 68:4700.
3. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227.
4. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287.
5. Bonino, F., F. Negro, M. Baldi, M. R. Brunetto, E. Chiaberge, M. Capalbo, E. Maran, C. Lavarini, N. Rocca, and C. Rocca. 1987. The natural history of chronic delta hepatitis. In The Hepatitis Delta Virus and its Infection. M. Rizzetto, J. L. Gerin, R. H. Purcell, eds. Alan R. Liss, New York, pp. 142-152.
6. Smedile, A., P. Farci, G. Verme, F. Caredda, A. Cargnel, N. Caporaso, P. Dentico, C. Trepo, P. Opolon, A. Gimson, D. Vergani, R. Williams, and M. Rizzetto, 1982. Influence of delta infection on severity of hepatitis B. Lancet 2:945.
7. Wang. K. S., Q. L. Choo, A. J. Weiner, J. H. Ou, R. C. Najarian, R. M. Thayer, G. T. Mullenbach, K. J. Denniston, J. L. Gerin, and M. Houghton. 1986. Structure, sequence, and expression of the hepatitis delta (δ) viral genome. Nature 323:508.
8. Chao, M., S-Y. Hsieh, and J. Taylor. 1990. Role of two forms of hepatitis delta virus antigen: evidence for a mechanism of self-limiting genome replication. J. Virol. 64:5066.
9. + T cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T helper cytokine profiles. J. Virol. 71:2241.
10. Hammer, J., P. Valsasnini, K. Tolba, D. Bolin, J. Higelin, B. Takacs, and F. Sinigaglia. 1993. Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell 74:197.
11. Rice, W. G., and S. J. Weiss. 1990. Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science 249:178.
12. Adorini, L., S. J. Ullrich, E. Appella, and S. Fuchs. 1990. Brefeldin A inhibits presentation of exogenous protein antigens to MHC class II-restricted T cells. Nature 346:63.
13. Braciale, T. J., L. A. Morrison, M. T. Sweetser, J. Sambrook, M. J. Gething, and V. L. Braciale. 1987. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol. Rev. 98:95.
14. Nuchtern, J. G., J. S. Bonifacino, W. E. Biddison, and R. D. Klausner. 1989. Brefeldin A implicates egress from endoplasmic reticulum in class I-restricted antigen presentation. Nature 399:223.
15. Kozlowski, S., M. Corr, T. Takeshita, L. F. Boyd, C. D. Pendleton, R. N. Germain, J. A. Berzofsky, and D. H. Margulies. 1992. Serum angiotensin-1-converting enzyme activity processes a human immunodeficiency virus gp160 peptide for presentation by major histocompatibility complex class I molecules. J. Exp. Med. 175:1417.
16. Sherman, L. A., T. A. Burke, and J. A. Biggs. 1992. Extracellular processing of peptide antigens that bind class I major histocompatibility molecules. J. Exp. Med. 175.-1221.
17. Widmann, C., J. L. Maryanski, P. Romero, and G. Corradin. 1991. Differential stability of antigenic MHC class I-restricted synthetic peptides. J. Immunol. 147: 3745.
18. Lai, M. M. C., Y.-P. Xia, S. B. Hwang, and C.-Z, Lee. 1993. Functional domains of hepatitis delta antigen. Prog. Clin. Biol. Res. 382:21.
19. Lee, P., G. Matsueda, and P. M. Alien. 1988. T cell recognition of fibrinogen: a determinant on the A α-chain does not require processing. J. Immunol. 140:1063.
20. Sette, A., L. Adorini, S. Colon, S. Buus, and H. Grey. 1989. Capacity of intact proteins to bind to MHC class II molecules. J. Immunol. 143:1265.
21. Rock, K. L. 1996. A new foreign policy: MHC class I molecules monitor the outside world. Immunol. Today 17:131.
22. Franco, A., V. Barnaba, P. G. Natali, C. Balsano, A. Musca, and F. Balsano. 1988. Expression of class I and class II major histocompatibility antigens on human hepatocytes. Hepatology 8:449.
23. Rammensee, H.-G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
24. Adorini, L., J. C. Guéry, S. Fuchs, V. Ortiz-Navarretc, G. J. Hammerling, and F. Momburg. 1993. Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells. J. Immunol. 151:3576.
25. Barnaba, V. 1996. Viruses, hidden self-epitopes, and autoimmunity. Immunol. Rev. 152:47.
26. Adorini, L., J. Moreno, F. Momburg, G. J. Hammerling, J. C. Quéry, A. Valli, and S. Fuchs. 1991. Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells. J. Exp. Med. 174:945.
27. Zinkernagel, R. M. 1996. Immunology taught by viruses. Science 271:173.