Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type

Blood

Volumn 97, Issue 8, 2001, Pages 2401-2405

  Seitz, Volkhard ^a   Hummel, Michael ^a   Anagnostopoulos, Ioannis ^a   Stein, Harald ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; PROTEIN BCL 6;

ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; FOLLICULAR LYMPHOMA; GENE EXPRESSION REGULATION; GENE MUTATION; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPHENOTYPING; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; SOMATIC MUTATION;

EID: 0035871675     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.8.2401     Document Type: Article

References (22)

1. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
2. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
3. Frequent somatic hypermutation of the 5′ noncoding region of the BCL-6 gene in B-cell lymphoma
4. Somatic mutation of the 5′ noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma
5. Mutation analysis of the 5′ noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: Evidence for recurrent mutations and intraclonal heterogeneity
6. Rearrangements of the BCL-6 gene in diffuse large cell non-Hodgkin's lymphoma
7. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia
8. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells
9. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development
10. Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient
11. Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
12. Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease
13. Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease
14. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)
15. Brief, high-temperature heat denaturation (pressure cooking): A simple and effective method of antigen retrieval for routinely processed tissues
16. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells
17. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
18. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
19. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease
20. Classical Hodgkin disease and follicular lymphoma originating from the same germinal center B cell
21. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma
22. Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells