IL-6 Is an in Vitro and in Vivo Autocrine Growth Factor for Middle T Antigen-Transformed Endothelial Cells

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2618-2623

  Giraudo, Enrico ^a   Arese, Marco ^a   Toniatti, Carlo ^b   Strasly, Marina ^a   Primo, Luca ^a   Mantovani, Alberto ^c,d   Ciliberto, Gennaro ^b   Bussolino, Federico ^a,e  

^a UNIVERSITY OF TURIN   (Italy)

^b Institute for Biomolecular Research   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

^e Biologia e Chimica Medica   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH PROMOTOR; INTERLEUKIN 6; VIRUS T ANTIGEN;

ANIMAL; ARTICLE; C57BL MOUSE; CELL LINE; DBA MOUSE; DRUG EFFECT; FEMALE; HEMANGIOMA; IMMUNOLOGY; MALE; MOUSE; PATHOLOGY; PHYSIOLOGY; POLYOMA VIRUS; VASCULAR ENDOTHELIUM; VIRUS CELL TRANSFORMATION;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; ENDOTHELIUM, VASCULAR; FEMALE; GROWTH SUBSTANCES; HEMANGIOMA; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; POLYOMAVIRUS;

EID: 0030587078     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Hirano, T., S. Akira, T. Taga, and T. Kishimoto. 1990. Biological and clinical aspects of interleukin 6. Immunol. Today 11:443.
2. Kishimoto, T., S. Akira, M. Narazaki, and T. Taga. 1995. Interleukin-6 family of cytokines and gp130. Blood 86:1243.
3. Kawano, M., T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, A. Kuramoto, and T. Kishimoto. 1988. Autocrine generation and essential requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83.
4. Schwab, G., C. B. Siegall, L. A. Aarden, L. M. Neckers, and R. P. Nordan. 1991. Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 77:587.
5. Biondi, A., V. Rossi, T. Bassan, S. Barbui, S. Bettoni, M. Sironi, A. Mantovani, and A. Rambaldi. 1989. Constitutive expression of the interleukin 6 gene in chronic lymphocytic leukemia. Blood 73:1279.
6. Barut, B., D. Chauhan, H. Uchiyama, and K. C. Anderson. 1993. Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro. J. Clin. Invest. 92:2346.
7. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell 76:253.
8. Campbell, I. L., C. R. Abraham, E. Masliah, P. Kemper, J. D. Inglis, M. B. A. Oldstone, and L. Mucke. 1993. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA 90:10061.
9. Brett, F. M., A. P. Mizisin, H. C. Powell, and I. L. Campbell. 1995. Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J. Neuropathol. Exp. Neurol. 54:766.
10. Motro, B., A. Itin, L. Sachs, and E. Keshet. 1990. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc. Natl. Acad. Sci. USA 87:3092.
11. Shalaby, M. R., A. Waage, and T. Espevik. 1989. Cytokine regulation of interleukin 6 production by human endothelial cells. Cell. Immunol. 121:372.
12. Sironi, M., F. Breviario, P. Proserpio, A. Biondi, A. Vecchi, J. Van Damme, E. Dejana, and A. Mantovani. 1989. IL-1 stimulates IL-6 production in endothelial cells. J. Immunol. 142:549.
13. Andert, S. E., A. Griesmacher, A. Zuckermann, and M. M. Muller. 1992. Neopterin release from human endothelial cells is triggered by interferon-gamma. Clin. Exp. Immunol. 88:555.
14. Miles, S. A., A. Rezai, J. F. Salazar-Gonzales, M. V. Meyden, H. Stevens, D. M. Logan, R. T. Mitsuyasu, T. Taga, T. Hirano, T. Kishimoto, and O. Martinez-Maza. 1990. AIDS-Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc. Natl. Acad. Sci. USA 87:4068.
15. Bussolino, F., M. De Rossi, A. Sica, F. Colotta, J. M. Wang, E. Bocchietto, I. M. Padura, A. Bosia, E. Dejana, and A. Mantovani. 1991. Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. J. Immunol. 147:2122.
16. Williams, R. L., W. Risau, H. G. Zerwes, H. Drexler, A. Aguzzi, and E. Wagner. 1989. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 57:1053.
17. Garlanda, C., C. Parravicini, M. Sironi, M. De Rossi, R. Wainstok de Calmanovici, F. Carozzi, F. Bussolino, F. Colotta, A. Mantovani, and A. Vecchi. 1994. Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors. Proc. Natl. Acad. Sci. USA 91:7291.
18. Montesano, R., R. S. Pepper, U. Mohle-Steinlein, W. Risau, E. Wagner, and L. Orci. 1990. Increased proteolytic activity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogene. Cell 62:435.
19. Mantovani, A., B. Bottazzi, F. Colotta, S. Sozzani, and L. Ruco. 1992. The origin and function of tumor-associated macrophages. Immunol. Today 13:265.
20. Taraboletti, G., D. Belotti, E. Dejana, A. Mantovani, and R. Giavazzi. 1993. Endothelial cell migration and invasiveness are induced by soluble factor produced by murine endothelioma cells transformed by polyoma virus mT oncogene. Cancer Res. 53:3812.
21. Ghigo, D., M. Arese, R. Todde, A. Vecchi, F. Silvagno, C. Costamagna, Q. D. Dong, M. Alessio, R. Heller, R. Soldi, F. Trucco, G. Garbarino, G. Pescarmona, A. Mantovani, F. Bussolino, and A. Bosia. 1995. Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase. J. Exp. Med. 181:9.
22. Salahuddin, S. Z., S. Nakamura, P. Biberfeld, M. H. Kaplan, P. D. Markham, L. Larsson, and R. C. Gallo. 1988. Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science 242:430.
23. Bocchietto, E., A. Guglielmetti, F. Silvagno, G. Taraboletti, G. P. Pescarmona, A. Mantovani, and F. Bussolino. 1993. Proliferative and migratory responses of murine microvascular endothelial cells to granulocyte-colony-stimulating factor. J. Cell. Physiol. 155:89.
24. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 230:680.
25. Fiorillo, M. T., C. Toniatti, J. Van Snick, and G. Ciliberto. 1992. Expression of the murine interleukin-6 receptor in hepatoma cells: the intracytoplasmic domain is not required fro interleukin-6 signal transduction. Eur. J. Immunol. 22:799.
26. Saito, T., K. Yasukawa, H. Suzuki, K. Futatsugi, T. Fukunaga, C. Yokomizo, Y. Koishihara, H. Fukui, Y. Ohsugi, H. Yawata, I. Kobayashi, T. Hirano, T. Taga, and T. Kishimoto. 1991. Preparation of soluble murine IL-6 receptor and anti-murine IL-6 receptor antibodies. J. Immunol. 147:168.
27. Vink, A., P. Coulie, G. Warnier, J. C. Renauld, M. Stevens, D. Donckers, and J. Van Snick. 1990. Mouse plasmacytoma growth in vivo: enhancement by interleukin-6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor. J. Exp. Med. 172:997.
28. Vecchi, A., C. Garlanda, M. G. Lampugnani, M. Resnati, C. Matteucci, A. Stoppacciaro, H. Schnurch, W. Risau, L. Ruco, A. Mantovani, and E. Dejana. 1994. Monoclonal antibodies specific for endothelial cells of mouse blood vessel: their application in the identification of adult and embrionyc endothelium. Eur. J. Cell Biol. 63:247.
29. Sugita, T., T. Totsuka, M. Saito, K. Yamasaki, T. Taga, T. Hirano, and T. Kishimoto. 1990. Functional murine interleukin 6 receptor with the intracisternal a particle gene product at its cytoplasmic domain: its possible role in plasmocytogenesis. J. Exp. Med. 171:2001.
30. 2-terminal amino acid sequence of a T-cell derived lymphokine with growth factor activity for B-cell hybridomas. Proc. Natl. Acad. Sci. USA 83:9679.
31. Kaplan, E. L., and P. Meier. 1958. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457.
32. Pietzko, D., D. Zohlnhofer, L. Graeve, D. Fleischer, T. Stoyan, H. Schooltink, S. Rose-John, and P. C. Heinrich. 1993. The hepatic interleukin-6 receptor: studies on its structure and regulation by phorbol 12-myristate 13-acetate and dexamethasone. J. Biol. Chem. 268:4250.
33. D'Alessandro, F., O. R. Calamonici, and R. P. Nordan. 1993. Direct association of interleukin-6 with 130-kDa component of the interleukin-6 receptor system. J. Biol. Chem. 268:2149.
34. Klein, B., J. Wijdenes, X-G. Zhang, M. Jourdan, J-M. Boiron, J. Brochier, J. Liautard, M. Merlin, C. Clement, B. Morel-Fournier, Z. Y. Lu, P. Mannoni, J. Sany, and R. Bataille. 1991. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78:1198.
35. Suzuki, H., K. Yasukawa, T. Saito, R. Goitsuka, A. Hasegawa, Y. Ohsugi, T. Taga, and T. Kishimoto. 1992. Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo. Eur. J. Immunol. 22:1989.
36. Orosz, P., A. Kruger, M. Hubbe, J. Ruschoff, P. Von-Hoegen, and D. N. Mannel. 1995. Promotion of experimental liver metastasis by tumor necrosis factor. Int. J. Cancer 60:867.
37. Chirivi, R. G., A. Garofalo, I. M. Padura, A. Mantovani, and R. Giavazzi. 1993. Interleukin 1 receptor antagonists inhibits the augmentation of metastasis induced by interleukin 1 or lipolysaccharide in a human melanoma/nude mouse system. Cancer Res. 53:5051.
38. Vidal-Vanaclocha, F., C. Amezaga, A. Asumendi, G. Kaplanski, and D. A. Dinarello. 1994. Interelukin-1 receptor blockade reduces the number and the size of murine B16 melanoma hepatic metastases. Cancer Res. 54:2667.
39. Qin, Z., S. Kruger-Krasagakes, U. Kunzendorf, H. Hock, T. Diamantstein, and T. Blankenstein. 1993. Expression of tumor necrosis factor by different cell lines results either in tumor suppression or augmented metastasis. J. Exp. Med. 178: 355.
40. Ueda, T., E. Shimada, and T. Urakawa. 1994. Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J. Gastroenterol. 29:423.
41. Cohen, T., D. Nahari, L. Weiss Cerem, G. Neufeld, and B. Z. Levi. 1996. Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. 271:736.
42. Kiefer, F., I. Anhauser, P. Soriano, A. Aguzzi, S. A. Courtneidge, and E. F. Wagner. 1994. Endothelial cell transformation by the polyomavirus middle T antigen in mice lacking Src-related kinases. Curr. Biol. 4:100.
43. 1. Cancer Res. 55:2262.
44. Kawano, M. M., K. Mihara, N. Huang, T. Tsujimoto, and A. Kuramoto. 1995. Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis. Blood 85:487.
45. Lunardi-Iskandar, Y., J. L. Bryant, R. A. Zeman, V. H. Lam, F. Samaniego, J. M. Besnier, P. Hermans, A. R. Thierry, P. Gill, and R. C. Gallo. 1995. Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Nature 375:64.
46. Havercos, H. W., D. P. Drotman, and M. Morgan. 1985. Prevalence of Kaposi's sarcoma among patients with AIDS. New Engl. J. Med. 312:1518.
47. Radka, S. F., S. Nakamura, S. Sakurada, and S. Z. Salahudin. 1993. Correlation of oncostatin M secretion by human retrovirus-infected cells with potent growth stimulation of cultured spindle cells from AIDS-Kaposi's sarcoma. J. Immunol. 150:5195.
48. Yoshizaki, K., T. Matsuda, N. Nishimoto, T. Kuritani, L. Tahebo, K. Aozasa, T. Nakahata, H. Kawai, H. Tagoh, T. Komori, S. Kishimoto, T. Hirano, and T. Kishimoto. 1989. Pathogenetic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74:1360.
49. Soulier, J., L. Grollet, E. Oksenhendler, P. Cacoub, D. Cazals-Hatem, P. Babinet, M. F. d'Agay, J. P. Clauvel, M. Raphael, L. Degos, and F. Sigaux. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castelan's disease. Blood 86:1276.