Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection

Journal of Infectious Diseases

Volumn 182, Issue 3, 2000, Pages 662-670

  Koelle, David M ^a,b   Schomogyi, Mark ^a,c   Corey, Lawrence ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMPHOTERICIN B; CD16 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN;

ANTIGEN SPECIFICITY; ARTICLE; DILUTION; FEMALE; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; UTERINE CERVIX;

ANTIGENS, VIRAL; CELL DIVISION; CELLS, CULTURED; CERVIX UTERI; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; IMMUNITY, MUCOSAL; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033823579     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315749     Document Type: Article

References (51)

1. Two double-blind, placebo-controlled trials of a vaccine containing recombinant gD2 and gB2 antigens in MF59 adjuvant for the prevention of genital HSV-2 acquisition
2. Herpes simplex virus type 2 in the United States, 1976 to 1994
3. Frequent genital herpes simplex virus 2 shedding in immunocompetent women: Effect of acyclovir treatment
4. Reinfection is an uncommon occurrence in patients with symptomatic recurrent genital herpes
5. Analysis of DNA from recurrent genital herpes simplex isolates by restriction endonuclease digestion
6. Demonstration of exogenous reinfection with herpes simplex virus type 2 by restriction endonuclease fingerprinting of viral DNA
7. Demonstration of either endogenous recurrence or exogenous reinfection by restriction endonuclease cleavage analysis of herpes simplex virus from patients with recrudescent genital herpes
8. A prospective study of new infections with herpes simplex virus type 1 and type 2: Chiron HSV Study Group
9. The acquisition of herpes simplex virus during pregnancy
10. Experimental human reinfection with herpes simplex virus
11. Analysis of herpes simplex virus-specific T cells in the murine female genital tract following infection with herpes simplex virus type 2
12. Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract
13. Genital herpes in a primary care clinic: Demographic and sexual correlates of herpes simplex type 2 infections
14. Virologic characteristics of subclinical and symptomatic genital herpes infections
15. Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir
16. Protein-specific cervical antibody responses to primary genital herpes simplex virus type 2 infections
17. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunoblot for detecting antibodies to herpes simplex types 1 and 2 in human sera
18. Typing of clinical HSV isolates using mouse monoclonal antibodies to HSV-1 and HSV-2: Comparison with type-specific rabbit antisera and restriction endonuclease analysis of viral DNA
19. HIV-1 induces cytotoxic T lymphocytes in the cervix of infected women
20. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
21. - herpes simplex virus-specific cytotoxic T lymphocyte clones recognize diverse virion protein antigens
22. + T cell clones recovered from recurrent genital HSV-2 lesions
23. Use of monoclonal antibodies against two 75,000-molecular-weight glycoproteins specified by herpes simplex virus type 2 in glycoprotein identification and gene mapping
24. The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene
25. The ULI3 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein a22
26. Direct recovery of HSV-specific T lymphocyte clones from human recurrent HSV-2 lesions
27. Direct demonstration of the clonogenic potential of every human peripheral blood T cell
28. + cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes
29. Herpes simplex virus (HSV)-specific proliferative and cytotoxic T-cell responses in humans immunized with an HSV type 2 glycoprotein subunit vaccine
30. + cytotoxic T lymphocytes
31. + T cells in corneas of herpetic stromal keratitis patients
32. T cells specific for the triggering virus infiltrate the eye in patients with herpes simplex virus-mediated acute retinal necrosis
33. Immunophenotypic analysis of the transformation zone of human cervix
34. Langerhans' cells and lymphocyte subsets in the female genital tract
35. The distribution of immunocompetent cells in the genital tract of HIV-positive women
36. Quantitative analysis of immunocompetent cells in human normal oral and uterine cervical mucosa, oral papillomas and leukoplakias
37. Langerhans' cells in human cervical epithelium: An immunohistologic study
38. Langerhans cell- and T-lymphocyte functions in patients with atopic dermatitis with disseminated cutaneous herpes simplex virus infection
39. Langerhans cell antigen presentation and interleukin 1 production in atopic dermatitis
40. Studies of epidermal Langerhans cells, II: Activation of human T lymphocytes to herpes simplex virus
41. Studies of human epidermal Langerhans cells, IV: HLA-D restriction of Langerhans cell-dependent antigen activation of T lymphocytes
42. HLA-D/DR restriction of Langerhans cell-dependent antigen activation of T lymphocytes
43. Inhibition of dendritic cell maturation by herpes simplex virus
44. Herpes simplex virus type 1 glycoproteins gB, gC, and gD are major targets for CD4 T-lymphocyte cytotoxicity in HLADR expressing human epidermal keratinocytes
45. Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-γ
46. Endocrine regulation of mucosal immunity: Effect of sex hormones and cytokines on the afferent and efferent arms of the immune system in the female reproductive tract
47. A simple method for the propagation of cervical lymphocytes
48. Human cytotoxic T cell clones directed against herpes simplex virus-infected cells, IV: Recognition and activation by cloned glycoproteins gB and gD-1
49. Contemporary approaches to vaccination against herpes simplex virus
50. Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions