Tyrosine kinase-dependent, phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma cells from anoikis

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2439-2444

  Wei, L ^a   Yang, Y ^a   Yu, Q ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL STRAIN; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOCARCINOMA; ANOIKIS; CELL ADHESION; CELL SURVIVAL; ENZYME INHIBITORS; GENISTEIN; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0035866766     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Disruption of epithelial cell-matrix interactions induces apoptosis
2. Integrins and anoikis
3. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells
4. Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis
5. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
6. Anchorage dependence, integrins, and apoptosis
7. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
8. Signaling through focal adhesion kinase
9. Integrin signaling and tyrosine phosphorylation: Just the FAKs?
10. Control of adhesion-dependent cell survival by focal adhesion kinase
11. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
12. Ras signaling and apoptosis
13. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
14. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
15. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival
16. Dual potential of extracellular signal-regulated kinase for the control of cell survival
17. MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes
18. Anchorage and growth regulation in normal and virus-transformed cells
19. Growth control in HeLa cells by serum and anchorage
20. Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells
21. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells
22. The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers
23. Tyrphostins suppress the growth of psoriatic keratinocytes
24. Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
25. Phosphorylation site-specific inhibition of platelet-derived growth factor β-receptor autophosphorylation by the receptor blocking tyrphostin AG1296
26. Tyrphostins as molecular tools and potential antiproliferative drugs
27. Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells
28. cSrc is a major cytosolic tyrosine kinase in vascular tissue
29. Tyrphostin induced growth inhibition: Correlation with effect on p210ber-ab1 autokinase activity in K562 chronic myelogenous leukemia
30. Expression of epidermal and nerve growth factor receptors and soft agar growth factor production by human lung cancer cells
31. Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line
32. Epidermal growth factor receptor expression in human lung cancer cell lines
33. Growth control by epidermal growth factor and transforming growth factor-alpha in human lung squamous carcinoma cells
34. Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas
35. Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer
36. Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: Involvement of receptor-directed protein tyrosine phosphatase(s)
37. Evidence for a role of EGF receptor in the progression of human lung carcinoma