Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells

Journal of Cellular Biochemistry

Volumn 65, Issue 3, 1997, Pages 420-429

  Klein, B Y ^a   Tepper, S H ^a   Gal, I ^a   Shlomai, Z ^a   Ben Bassat, H ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

benzylidene malononitrile; cell proliferation; marrow stroma; osteoprogenitors; osteosarcoma; quinazoline; tyrphostins

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; AG 555; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MATRIX; BONE MINERALIZATION; BONE REMODELING; BONE TUMOR; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; OSTEOSARCOMA; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ALKALINE PHOSPHATASE; ANIMALS; BENZYLIDENE COMPOUNDS; BONE MARROW; BONE NEOPLASMS; CALCIFICATION, PHYSIOLOGIC; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; NITRILES; OSTEOSARCOMA; PROTEIN-TYROSINE KINASES; RATS; STEM CELLS; STROMAL CELLS; TUMOR CELLS, CULTURED; TYRPHOSTINS;

ANIMALIA;

EID: 0030892788     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19970601)65:3<420::AID-JCB11>3.0.CO;2-J     Document Type: Article

References (24)

1. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh NM, Shibuya M, Fukami Y (1987): Genistein, a specific inhibitor of tyrosine specific protein kinases. J Biol Chem 262:5592-5595.
2. Ben-Bassat H, Vardi DV, Gazit A, Klaus SN, Chaouat M, Hartzstark Z, Levitzki A (1995): Tyrphostins suppress the growth of psoriatic keratinocytes. Exp Dermatol 4: 82-88.
3. Blumenthal NC, Betts F, Posner AS (1977): Stabilization of amorphous calcium phosphate by Mg and ATP. Calcif Tissue Res 23:245-250.
4. Davis AM, Bell RS, Goodwin PJ (1994): Prognostic factors in osteosarcoma: A critical review. J Clin Oncol 12:423-431.
5. Hall TE, Schaublin M, Missbach M (1994): Evidence that c-src is involved in the process of osteoclastic bone resorption. Biochem Biophys Res Commun 199:1237-1244.
6. Hatori M, Teixeira CC, Debolt K, Pacifici M, Shapiro IM (1995): Adenine nucleotide metabolism by chondrocytes in vitro: Role of ATP in chondrocyte maturation and matrix mineralization. J Cell Physiol 165:468-474.
7. Hudson LG, Santon JB, Gill GN (1989): Regulation of epidermal growth factor receptor gene expression. Mol Endocrinol 3:400-408.
8. Huvos AG, Rosen G, Marcove RC (1977): Primary osteogenic sarcoma. Arch Pathol Lab Med 101:14-18.
9. Kim KM (1995): Apoptosis and calcification. Cells Materials 9:1137-1178.
10. Klein BY, Gal I, Segal D (1993a): Selection of malonate-resistant stromal cell-derived osteoprogenitor cells in vitro. J Cell Biochem 51:190-197.
11. Klein BY, Gal I, Segal D (1993b): Studies of the levamisole inhibitory effect on rat stromal-cell commitment to mineralization. J Cell Biochem 53:114-121.
12. Klein BY, Gal I, Hartshtark Z, Segal D (1993c): Induction of osteoprogenitor cell differentiation in rat marrow stroma increases mitochondrial retention of rhodamine 123 in stromal cells. J Cell Biochem 53:190-197.
13. Klein BY, Rojansky N, Gal I, Shlomai Z, Liebergall M, Ben-Bassat H (1995): Analysis of cell-mediated mineralization in culture of bone derived embryonic cells with neurofibromatosis. J Cell Biochem 57:530-542.
14. Klein BY, Gal I, Libergal M, Ben-Bassat H (1996a): Opposing effects on mitochondrial membrane potential by malonate and levamisole, whose effect on cell-mediated mineralization is antagonistic. J Cell Biochem 60:139-147.
15. Klein BY, Gal I, Ben-Bassat H (1996b): Cell-mediated mineralization in culture at low temperature associated with subtle thermogenesis. J Cell Biochem 63:229-238.
16. Levitzki A, Gazit A (1995): Tyrosine kinase inhibition: An approach to drug development. Science 267:1782-1783.
17. Lundh TJO, Lundgren BO (1991): Uncoupling and inhibition of respiratory chain in rat-liver mitochondria by some naturally occurring estrogens and their metabolites. J Agr Food Chem 39:736-739.
18. Maniatopoulos C, Sodek J, Melcher AH (1988): Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 254:317-330.
19. Massina MJ, Persky V, Setchell KDR, Barnes S (1994): Soy intake and cancer risk: A review of in vitro and in vivo data. Nutr Cancer 21:113-131.
20. Osherov N, Levitzki A (1994): Epidermal growth factor dependent activation of src family kinases. Eur J Biochem 225:1047-1053.
21. Osherov N, Gazit A, Gilon C, Levitzki A (1995): Selective inhibition of the epidermal growth factor and HER2/neu receptor by tyrphostins. J Biol Chem 268:11134-11142.
22. Pawson T (1992): Tyrosine kinases and their interactions with signaling proteins. Curr Opin Genet Dev 2:4-12.
23. Ullrich A, Schlessinger J (1990): Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
24. c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo. J Clin Invest 91:2791-2795.