The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer

EMBO Journal

Volumn 18, Issue 21, 1999, Pages 6062-6072

  De Souza, Flávio S J ^a   Gawantka, Volker ^a   Gómez, Aitana Perea ^b   Delius, Hajo ^a   Ang, Siew Lan ^b   Niehrs, Christof ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Blimp 1; Cerberus; Endoderm; Head formation; PRDI BF1

Indexed keywords

ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FATE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO INDUCTION; ENDODERM; GENE FUNCTION; HEAD; MESODERM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CLONING, MOLECULAR; EMBRYONIC INDUCTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOPROTEINS; HEAD; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESODERM; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; XENOPUS; XENOPUS PROTEINS; ZINC FINGERS;

ANIMALIA; CERBERUS; VERTEBRATA;

EID: 0033231225     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.21.6062     Document Type: Article

References (70)

1. Banville, D. and Williams, J.G. (1985) The pattern of expression of the Xenopus laevis tadpole α-globin genes and the amino acid sequence of the three major tadpole α-globin polypeptides. Nucleic Acids Res., 13, 5407-5421.
2. Beddington, R.S.P. and Robertson, E.J. (1999) Axis development and early asymmetry in mammals. Cell, 96, 195-209.
3. Belo, J.A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M. and De Robertis, E.M. (1997) Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev., 68, 45-57.
4. Biben, C. et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol., 194, 135-151.
5. Blitz, I.L. and Cho, K.W.Y. (1995) Anterior neuroectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Development, 121, 993-1004.
6. Bouwmeester, T. and Leyns, L. (1997) Vertebrate head induction by anterior primitive endoderm. BioEssays, 19, 855-863.
7. Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B. and De Robertis, E.M. (1996) Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature, 382, 595-601.
8. Cho, K.W., Blumberg, B., Steinbeisser, H. and De Robertis, E.M. (1991) Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell, 67, 1111-1120.
9. Conlon, R.A. and Herrmann, B.G. (1993) Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts. Methods Enzymol., 225, 373-383.
10. Dosch, R., Gawantka, V., Delius, H., Blumenstock, C. and Niehrs, C. (1997) Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development, 124, 2325-2334.
11. Ecochard, V., Cayrol, C, Rey, S., Foulquier, F., Caillol, D., Lemaire, P. and Duprat, A.P. (1998) A novel Xenopus Mix-like gene milk involved in the control of the endomesodermal fates. Development, 125, 2577-2585.
12. Ferreiro, B., Artinger, M., Cho, K.W.Y. and Niehrs, C. (1998) Antimorphic goosecoids. Development, 125, 1347-1359.
13. Friedman, A.D., Triezenberg, S.J. and McKnight, S.L. (1988) Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus. Nature, 335, 452-454.
14. Gawantka, V., Delius, H., Hirschfeld, K., Blumenstock, C. and Niehrs, C. (1995) Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. EMBO J., 14, 6268-6279.
15. Gawantka, V., Pollet, N., Delius, H., Pfister, R., Vingron, M., Nitsch, R., Blumenstock, C. and Niehrs, C. (1998) Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning. Mech. Dev., 77, 95-141.
16. Gilbert, S.F. and Saxen, L. (1993) Spemann's organizer: models and molecules. Mech. Dev., 41, 73-89.
17. Glinka, A., Delius, H., Blumenstock, C. and Niehrs, C. (1996) Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium. Mech. Dev., 60, 221-231.
18. Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C. and Niehrs, C. (1997) Head induction by simultaneous repression of Bmp and wnt signalling in Xenopus. Nature, 389, 517-519.
19. Glinka, A, Wu, W., Delius, H., Monaghan, P.A., Blumenstock, C. and Niehrs, C. (1998) Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature, 391, 357-362.
20. Han, K. and Manley, J.L. (1993) Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. Genes Dev., 7, 491-503.
21. Harland, R.M. (1991) In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol., 36, 685-695.
22. Hemmati-Brivanlou, A., Kelly, O.G. and Melton, D.A. (1994) Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell, 77, 283-295.
23. Henry, G.L. and Melton, D.A. (1998) Mixer, a homeobox gene required for endoderm development. Science, 281, 91-96.
24. Henry, G.L., Brivanlou, I.H., Kessler, D.S., Hemmati, B.A. and Melton, D.A. (1996) TGF-β signals and a pattern in Xenopus laevis endodermal development. Development, 122, 1007-1015.
25. Hopwood, N.D., Pluck, A. and Gurdon, J.B. (1991) Xenopus Myf-5 marks early muscle cells and can activate muscle genes ectopically in early embryos. Development, 111, 551-560.
26. Hudson, C., Clements, D., Friday, R.V., Stott, D. and Woodland, H.R. (1997) Xsox17α and -β mediate endoderm formation in Xenopus. Cell. 91, 397-405.
27. Joseph, E.M. and Melton, D.A. (1998) Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. Development, 125, 2677-2685.
28. Keller, A.D. and Maniatis, T. (1991) Identification and characterization of a novel represser of β-interferon gene expression. Genes Dev., 5, 868-879.
29. Keller, R. (1991) Early embryonic development of Xenopus laevis. Methods Cell Biol., 36, 61-113.
30. Kintner, C.R. and Melton, D.A. (1987) Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development, 99, 311-325.
31. Latinkic, B.V. and Smith, J.C. (1999) Goosecoid and Mix.1 repress brachyury expression and are required for head formation in Xenopus. Development, 126, 1769-1779.
32. Lemaire, P., Garrett, N. and Gurdon, J.B. (1995) Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell 81, 85-94.
33. Lemaire, F, Darras, S., Caillol, D. and Kodjabachian, L. (1998) A role for the vegetally expressed Xenopus gene Mix1 in endoderm formation and in the restriction of mesoderm to the marginal zone. Development, 125, 2371-2380.
34. Leyns, L., Bouwmeester, T., Kim, S.-H., Piccolo, S. and De Robertis, E.M. (1997) Frzb-1 is a secreted antagonist of wnt-signals expressed in the Spemann organizer. Cell, 88, 747-756.
35. Lin, Y., Wong, K. and Calame, K. (1997) Repression of c-myr transcription by Blimp-1, an inducer of terminal B cell differentiation. Science, 276, 596-599.
36. Messika, E.J., Lu, P.S., Sung, Y.J., Yao, T., Chi, J.T., Chien, Y.H. and Davis, M.M. (1998) Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. J. Exp. Med., 188, 515-525.
37. Mohun, T.J., Brennan, S. and Gurdon, J.B. (1984) Region-specific regulation of the actin multi-gene family in early amphibian embryos. Philos. Trans. R. Soc. Land. B Biol. Sci., 307, 337-342.
38. Moon, R.T. and Kimelman, D. (1998) From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. BioEssays, 20, 536-545.
39. Newman, C.S., Chia, F. and Krieg, P.A. (1997) The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Mech. Dev., 66, 83-93.
40. Niehrs, C. (1999) Head in the Wnt - the molecular nature of Spemann's head organizer. Trends Genet., 15, 314-319.
41. Nieuwkoop, P.D. and Florschütz, P.A. (1950) Quelques caracteres speciaux de la gastrulation et de la neurulation de l'oeuf de Xenopus laevis, Daud. et de quelques autres Anoures. I. Arch. Biol., 61, 113-150.
42. Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C. and Niehrs, C. (1996) The Xvent-2 homeobox gene is part of the BMP-4 signaling pathway controlling dorsoventral patterning of Xenopus mesoderm. Development, 122, 3045-3053.
43. Onichtchouk, D., Glinka, A. and Niehrs, C. (1998) Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm. Development, 125, 1447-1456.
44. Pannese, M., Polo, C., Andreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G. and Boncinelli, E. (1995) The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development, 121, 707-720.
45. Pasteels, J. (1949) Observations sur la localisation de la plaque prechordale et de l'entoblaste presomtifs au cours de la gastrulation chez Xenopus laevis. Arch. Biol., 60, 235-250.
46. Pearce, J.J.H., Penny, G. and Rossant, J. (1999) A mouse cerberus/dan-related gene family. Dev. Biol., 209, 98-100.
47. Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, J. and De Robertis, E.M. (1999) The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature, 397, 707-710.
48. Ren, B., Chee, K.J., Kim, T.H. and Maniatis, T. (1999) PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev., 13, 125-137.
49. Rhinn, M., Dierich, A., Shawlot, W., Behringer, R.R., Le Meur, M. and Ang, S.L. (1998) Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 125, 845-856.
50. Rosa, F.M. (1989) Mix. 1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos. Cell, 57, 965-974.
51. Rupp, R.A., Snider, L. and Weintraub, H. (1994) Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev., 8, 1311-1323.
52. Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L.K. and De Robertis, E.M. (1994) Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell, 79, 779-790.
53. Sasai, Y., Lu, B., Piccolo, S. and De Robertis, E.M. (1996) Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J., 15, 4547-4555.
54. Schneider, V.A. and Mercola, M. (1999) Spatially distinct head and heart inducers within the Xenopus organizer region. Curr. Biol., 9, 800-809.
55. Shawlot, W., Deng, J.M. and Behringer, R.R. (1998) Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Proc. Natl Acad. Sci. USA, 95, 6198-6203.
56. Slack, J.M. and Tannahill, D. (1992) Mechanism of anteroposterior axis specification in vertebrates. Lessons from the amphibians. Development, 114, 285-302.
57. Smith, J.C., Price, B.M., Green, J.B., Weigel, D. and Herrmann, B.G. (1991) Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell, 67, 79-87.
58. Smith, W.C. and Harland, R.M. (1992) Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell, 70, 829-840.
59. Taira, M., Otani, H., Jamrich, M. and Dawid, I.B. (1994) Expression of the LIM class homeobox gene Xlim-1 in pronephros and CNS cell lineages of Xenopus embryos is affected by retinoic acid and exogastrulation. Development, 120, 1525-1536.
60. Thomas, P. and Beddington, R. (1996) Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol., 6, 1487-1496.
61. Thomas, P.Q., Brown, A. and Beddington, R.S. (1998) Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development, 125, 85-94.
62. Turner, C.J., Mack, D.H. and Davis, M.M. (1994) Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell, 77, 297-306.
63. Varlet, I., Collignon, J and Robertson, E.J. (1997) nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development, 124, 1033-1044.
64. Walmsley, M.E., Guille, M.J., Bertwistle, D., Smith, J.C., Pizzey, J.A. and Patient, R.K. (1994) Negative control of Xenopus GATA-2 by activin and noggin with eventual expression in precursors of the ventral blood islands. Development, 120, 2519-2529.
65. Wang, S., Krinks, M., Lin, K., Luyten, F.P. and Moos, M. (1997) Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell, 88, 757-766.
66. Wang, Y., O'Malley, B.W., Jr, Tsai, S.Y. and O'Malley, B.W. (1994) A regulatory system for use in gene transfer. Proc. Natl Acad. Sci. USA, 91, 8180-8184.
67. Wilson, R. et al. (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C.elegans. Nature, 368, 32-38.
68. Zhang, J., Houston, D.W., King, M.L., Payne, C., Wylie, C. and Heasman, J. (1998) The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell, 94, 515-524.
69. Zon, L.I., Mather, C., Burgess, S., Bolce, M.E., Harland, R.M. and Orkin, S.H. (1991) Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc. Natl Acad. Sci. USA, 88, 10642-10646.
70. Zorn, A.R., Butler, K. and Gurdon, J.B. (1999) Anterior endomesoderm specification in Xenopus by Wnt/β-catenin and TGF-β signalling pathways. Dev. Biol., 209, 282-297.