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Volumn 9, Issue 3, 1997, Pages 358-363

Cyclin-dependent kinase and initiation at eukaryotic origins: A replication switch?

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE;

EID: 0030906338     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80008-7     Document Type: Article
Times cited : (46)

References (60)
  • 3
    • 0023905494 scopus 로고
    • Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity
    • Schneider J, Fanning E: Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity. J Virol 1988, 62:1598-1605.
    • (1988) J Virol , vol.62 , pp. 1598-1605
    • Schneider, J.1    Fanning, E.2
  • 4
    • 0024430871 scopus 로고
    • Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication
    • McVey D, Brizuela L, Mohr I, Marshak DR, Gluzman Y, Beach D: Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature 1989, 341:503-507.
    • (1989) Nature , vol.341 , pp. 503-507
    • McVey, D.1    Brizuela, L.2    Mohr, I.3    Marshak, D.R.4    Gluzman, Y.5    Beach, D.6
  • 5
    • 0027326021 scopus 로고
    • Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding
    • Moarefi IF, Small D, Gilbert I, Hopfner M, Randall SK, Schneider C, Russo AA, Ramsperger U, Arthur AK, Stahl H et al.: Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding. J Virol 1993, 67:4992-5002.
    • (1993) J Virol , vol.67 , pp. 4992-5002
    • Moarefi, I.F.1    Small, D.2    Gilbert, I.3    Hopfner, M.4    Randall, S.K.5    Schneider, C.6    Russo, A.A.7    Ramsperger, U.8    Arthur, A.K.9    Stahl, H.10
  • 6
    • 0027268605 scopus 로고
    • Cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen
    • McVey D, Ray S, Gluzman Y, Berger L, Wildeman AG, Marshak DR, Tegtmeyer P: cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J Virol 1993, 67:5206-5215.
    • (1993) J Virol , vol.67 , pp. 5206-5215
    • McVey, D.1    Ray, S.2    Gluzman, Y.3    Berger, L.4    Wildeman, A.G.5    Marshak, D.R.6    Tegtmeyer, P.7
  • 7
    • 0026732848 scopus 로고
    • Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
    • Virshup DM, Russo AA, Kelly TJ: Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. Mol Cell Biol 1992, 12:4883-4895.
    • (1992) Mol Cell Biol , vol.12 , pp. 4883-4895
    • Virshup, D.M.1    Russo, A.A.2    Kelly, T.J.3
  • 8
    • 0026620556 scopus 로고
    • The role of p34 kinases in the G1 to S-phase transition
    • Reed SI: The role of p34 kinases in the G1 to S-phase transition. Annu Rev Cell Biol 1992, 8:529-561.
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 529-561
    • Reed, S.I.1
  • 9
    • 0017138261 scopus 로고
    • Sequential function of gene products relative to DNA synthesis in the yeast cell cycle
    • Hartwell LH: Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J Mol Biol 1976, 104:803-817.
    • (1976) J Mol Biol , vol.104 , pp. 803-817
    • Hartwell, L.H.1
  • 10
    • 0019394338 scopus 로고
    • Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast
    • Nurse P, Bissett Y: Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 1981, 292:558-560.
    • (1981) Nature , vol.292 , pp. 558-560
    • Nurse, P.1    Bissett, Y.2
  • 11
    • 0027220020 scopus 로고
    • CLB5 and CLB6, a new pair of B cyclins involved in DNa replication in Saccharomyces cerevisiae
    • Schwob E, Nasmyth K: CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev 1993, 7:1160-1175.
    • (1993) Genes Dev , vol.7 , pp. 1160-1175
    • Schwob, E.1    Nasmyth, K.2
  • 13
    • 0028295757 scopus 로고
    • A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast
    • Obara-Ishihara T, Okayama H: A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast EMBO J 1994, 13:1863-1872.
    • (1994) EMBO J , vol.13 , pp. 1863-1872
    • Obara-Ishihara, T.1    Okayama, H.2
  • 14
    • 0027474903 scopus 로고
    • Two fission yeast B-type cyclins, cig2 and cdc13, have different functions in mitosis
    • Bueno A, Russell P: Two fission yeast B-type cyclins, cig2 and cdc13, have different functions in mitosis. Mol Cell Biol 1993, 13:2286-2297.
    • (1993) Mol Cell Biol , vol.13 , pp. 2286-2297
    • Bueno, A.1    Russell, P.2
  • 15
    • 0028012048 scopus 로고
    • Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle
    • Connolly T, Beach D: Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle. Mol Cell Biol 1994, 14:768-776.
    • (1994) Mol Cell Biol , vol.14 , pp. 768-776
    • Connolly, T.1    Beach, D.2
  • 18
    • 0029670828 scopus 로고    scopus 로고
    • cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins
    • ••] greatly clarify the role of B-type cyclins in regulating S-phase entry in fission yeast. Taken together, these studies demonstrate that the cyclin Cig2 plays a major role in activating DNA replication at the G1→S-phase transition - and that Cig2 in fact shares this starring role with a most unexpected colleague, the mitotic cyclin Cdc13. This S phase promoting function of Cdc13 is particularly intriguing, given the essential role of Cdc13 in preventing rereplication [20].
    • (1996) EMBO J , vol.15 , pp. 850-860
    • Fisher, D.L.1    Nurse, P.2
  • 22
    • 0029416996 scopus 로고
    • cdc2 mitotic kinase
    • ••] show that the Rum1 protein functions as an inhibitor of the mitotic Cdc2-Cdc13 kinase, which agrees with other work indicating that this kinase actively prevents rereplication [20].
    • (1995) Cell , vol.83 , pp. 1001-1009
    • Correa-Bordes, J.1    Nurse, P.2
  • 23
    • 0029878078 scopus 로고    scopus 로고
    • Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe
    • ••], negative regulation of Cdc18 by CDKs provides a potential mechanism by which DNA replication can be limited to once per cell cycle.
    • (1996) Genes Dev , vol.10 , pp. 541-552
    • Jallepalli, P.V.1    Kelly, T.J.2
  • 24
    • 0029410629 scopus 로고
    • S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state
    • Dahmann C, Diffley JF, Nasmyth KA: S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr Biol 1995, 5:1257-1269. Although the role of CDKs in preventing rereplication was first established in fission yeast, this report provides important evidence for a similar control mechanism in budding yeast. In the latter organism, it appears that both S-phase and mitotic cyclin-CDK complexes are involved in preventing re-replication. Experimental manipulations which lead to transient loss of all B-type cyclin-CDK activity result in the formation of prereplicative footprints at yeast origins and subsequent endoreduplication.
    • (1995) Curr Biol , vol.5 , pp. 1257-1269
    • Dahmann, C.1    Diffley, J.F.2    Nasmyth, K.A.3
  • 25
    • 0029013865 scopus 로고
    • Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila melanogaster
    • Sauer K, Knoblich JA, Richardson H, Lehner CF: Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila melanogaster. Genes Dev 1995, 9:1327-1339.
    • (1995) Genes Dev , vol.9 , pp. 1327-1339
    • Sauer, K.1    Knoblich, J.A.2    Richardson, H.3    Lehner, C.F.4
  • 26
    • 0029069867 scopus 로고
    • Qualifying for the license to replicate
    • Su TT, Follette PJ, O'Farrell PH: Qualifying for the license to replicate. Cell 1995, 81:825-828.
    • (1995) Cell , vol.81 , pp. 825-828
    • Su, T.T.1    Follette, P.J.2    O'Farrell, P.H.3
  • 27
    • 0030249292 scopus 로고    scopus 로고
    • A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
    • Stern B, Nurse P: A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet 1996, 12:345-350.
    • (1996) Trends Genet , vol.12 , pp. 345-350
    • Stern, B.1    Nurse, P.2
  • 28
    • 0030271945 scopus 로고    scopus 로고
    • At the heart of the budding yeast cell cycle
    • Nasmyth K: At the heart of the budding yeast cell cycle. Trends Genet 1996, 12:405-412.
    • (1996) Trends Genet , vol.12 , pp. 405-412
    • Nasmyth, K.1
  • 29
    • 0028240049 scopus 로고
    • Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle
    • Amon A, Irniger S, Nasmyth K: Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 1994, 77:1037-1050.
    • (1994) Cell , vol.77 , pp. 1037-1050
    • Amon, A.1    Irniger, S.2    Nasmyth, K.3
  • 31
    • 0029842867 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start
    • ••] demonstrate that the essential function of budding yeast CLNs is to promote the phosphorylation and proteolysis of the budding yeast B-type cyclin-CDK inhibitor SIC1. In the absence of SIC1, the requirement for CLNs is abolished. An important conclusion is that B-type cyclins are sufficient for all essential CDK activities in budding yeast.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7772-7776
    • Tyers, M.1
  • 32
    • 0026607331 scopus 로고
    • ATP-dependent recognition of eukaryotic origins of DNa replication by a multiprotein complex
    • Bell SP, Stillman B: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 1992, 357:128-134.
    • (1992) Nature , vol.357 , pp. 128-134
    • Bell, S.P.1    Stillman, B.2
  • 35
    • 0029919395 scopus 로고    scopus 로고
    • The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase
    • •].
    • (1996) Genes Dev , vol.10 , pp. 2644-2654
    • Grallert, B.1    Nurse, P.2
  • 40
    • 0030592518 scopus 로고    scopus 로고
    • Interaction between the origin recognition complex and the replication licensing system in Xenopus
    • cdc2 kinase. This observation suggests that CDKs associate with ORC in vivo, which may be important for the coordination of origin activity with the cell cycle.
    • (1996) Cell , vol.87 , pp. 287-296
    • Rowles, A.1    Chong, J.P.2    Brown, L.3    Howell, M.4    Evan, G.I.5    Blow, J.J.6
  • 42
    • 0024391026 scopus 로고
    • Molecular cloning of Saccharomyces cerevisiae CDC6 gene. Isolation, identification, and sequence analysis
    • Zhou C, Huang SH, Jong AY: Molecular cloning of Saccharomyces cerevisiae CDC6 gene. Isolation, identification, and sequence analysis. J Biol Chem 1989, 264:9022-9029.
    • (1989) J Biol Chem , vol.264 , pp. 9022-9029
    • Zhou, C.1    Huang, S.H.2    Jong, A.Y.3
  • 43
    • 0029082391 scopus 로고
    • Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae
    • 1 phase. CDC6 protein is highly unstable and must be synthesized at either one of these two points in every cell cycle in order to initiate DNA replication. Cells devoid of CDC6 fail to replicate but nevertheless undergo a 'reductional anaphase', generating cells with less than 1N DNA content. This phenotype mimics that previously observed in fission yeast cells lacking Cdc18 [41].
    • (1995) EMBO J , vol.14 , pp. 3788-3799
    • Piatti, S.1    Lengauer, C.2    Nasmyth, K.3
  • 44
    • 0028972375 scopus 로고
    • P65 cdc18 plays a major role controlling the initiation of DNa replication in fission yeast
    • ••].
    • (1995) Cell , vol.83 , pp. 397-405
    • Nishitani, H.1    Nurse, P.2
  • 45
    • 0029864759 scopus 로고    scopus 로고
    • + regulates initiation of DNA replication in Schizosaccharomyces pombe
    • ••]). Cells depleted of Cdc18 are capable of completing ongoing DNA synthesis but cannot initiate DNA replication in the subsequent cell cycle. Interestingly, strong overexpression of Cdc18 protein causes over-replication of DNA, leading to cells with greatly enlarged nuclei and abnormally high DNA contents.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1566-1570
    • Muzi Falconi, M.1    Brown, G.W.2    Kelly, T.J.3
  • 46
    • 0029048775 scopus 로고
    • ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
    • Liang C, Weinreich M, Stillman B: ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 1995, 81:667-676. Using two-dimensional gel methods, Stillman and coworkers provide direct evidence for the involvement of ORC and CDC6 in the initiation of DNA replication in budding yeast, as temperature-sensitive mutations in these genes reduce the frequency of origin firing in the yeast genome. This conclusion is reinforced by genetic studies which demonstrate synthetic lethal and dosage suppression interactions between ORC5 and CDC6. Coprecipitation experiments using proteins overexpressed in insect cells suggest that ORC and CDC6 can physically interact with one another.
    • (1995) Cell , vol.81 , pp. 667-676
    • Liang, C.1    Weinreich, M.2    Stillman, B.3
  • 47
    • 0030030623 scopus 로고    scopus 로고
    • An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
    • 1 phase is shown to depend genetically on CDC6. Moreover, this nuclease protection is thermolabile in a temperature-sensitive cdc6-1 mutant, suggesting that CDC6 is directly or indirectly required for the maintenance of the protected footprint prior to S phase.
    • (1996) Nature , vol.379 , pp. 180-182
    • Cocker, J.H.1    Piatti, S.2    Santocanale, C.3    Nasmyth, K.4    Diffley, J.F.X.5
  • 48
    • 0030271388 scopus 로고    scopus 로고
    • The Xenopus Cdc6 protein is essential for the initiation of a single round of DNa replication in cell-free extracts
    • Coleman TR, Carpenter PB, Dunphy WG: The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 1996, 87:53-63. This paper from Dunphy's group describes the Xenopus homolog (XCDC6) of the yeast Cdc18/CDC6 replication activator proteins and shows that XCDC6 is required for chromosomal replication in egg extracts. Interestingly, XCDC6 binds chromatin in early interphase but later becomes associated with the nuclear membrane. XCDC6 association with chromatin requires prior loading of XORC onto DNA, and XORC-XCDC6 chromatin-binding is itself required for the subsequent association of XMCMs with chromatin. These results suggest that the assembly of replication factors occurs in a precise stepwise fashion at potential sites of initiation.
    • (1996) Cell , vol.87 , pp. 53-63
    • Coleman, T.R.1    Carpenter, P.B.2    Dunphy, W.G.3
  • 50
    • 0029761435 scopus 로고    scopus 로고
    • 1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNa replication in yeast
    • 1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast Genes Dev 1996, 10:1516-1531. By using regulable promoters to express CDC6 at various points in the cell cycle, Piatti et a/, discovered that CDC6 can promote DNA replication only when expressed prior to the activation of S-phase cyclins. If cells are allowed to initiate S-phase CDK activation in the absence of CDC6, restoring CDC6 expression later in the cell cycle is insufficient to induce S phase. Interestingly, a small fraction of the CLB5-CDC28 kinase appears to associate with CDC6 and phosphorylate it in vitro.
    • (1996) Genes Dev , vol.10 , pp. 1516-1531
    • Piatti, S.1    Bohm, T.2    Cocker, J.H.3    Diffley, J.F.4    Nasmyth, K.5
  • 52
    • 0030924762 scopus 로고    scopus 로고
    • Interaction of the S phase regulator Cdc18 with cyclin-dependent kinase in fission yeast
    • in press
    • cdc2 in fission yeast). These kinases are also capable of phosphorylating Cdc18 and CDC6 in vitro. These results suggest the possibility that interaction between Cdc18/CDC6 and CDKs may have a role in regulating the onset of DNA replication in the two yeasts.
    • (1997) Proc Natl Acad Sci USA
    • Brown, G.W.1    Jallepalli, P.V.2    Huneycutt, B.J.3    Kelly, T.J.4
  • 53
    • 0142222460 scopus 로고
    • Introduction to cell cycle controls
    • Edited by Hutchison C, Glover DM. New York: Oxford University Press
    • Hartwell L: Introduction to cell cycle controls. In Cell Cycle Control. Edited by Hutchison C, Glover DM. New York: Oxford University Press; 1995:1-15.
    • (1995) Cell Cycle Control , pp. 1-15
    • Hartwell, L.1
  • 54
    • 0029861615 scopus 로고    scopus 로고
    • Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex
    • Hendrickson M, Madine M, Dalton S, Gautier J: Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex. Proc Natl Acad Sci USA 1996, 93:12223-12228. The Xenopus MCM4 (XMCM4) is found to be a substrate for Cdc2-cyclin B kinase in vitro and is phosphorylated at similar positions in vivo. Interestingly, high levels of Cdc2-cyclin B kinase in extracts block subsequent association of XMCM complexes with chromatin, although this may be an indirect effect mediated through modification of XORC or XCDC6 proteins as well as of XMCM4.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12223-12228
    • Hendrickson, M.1    Madine, M.2    Dalton, S.3    Gautier, J.4
  • 55
    • 0027479493 scopus 로고
    • Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle
    • Yoon HJ, Loo S, Campbell JL: Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Mol Biol Cell 1993, 4:195-208.
    • (1993) Mol Biol Cell , vol.4 , pp. 195-208
    • Yoon, H.J.1    Loo, S.2    Campbell, J.L.3
  • 56
    • 0028979307 scopus 로고
    • +, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication
    • +) indicates that Hsk1 is required for DNA replication and may also be involved in the control that restrains mitosis in the absence of DNA replication. The conserved role of Hsk1 and CDC7 in fission and budding yeasts suggests that this class of protein kinases will participate in the initiation of DNA replication in all eukaryotes.
    • (1995) EMBO J , vol.14 , pp. 3094-3104
    • Masai, H.1    Miyake, T.2    Arai, K.3
  • 57
    • 0027941616 scopus 로고
    • cdc2 kinase support DNa replication
    • cdc2 kinase support DNA replication. J Biol Chem 1994, 269:24203-24208.
    • (1994) J Biol Chem , vol.269 , pp. 24203-24208
    • Henricksen, L.A.1    Wold, M.S.2
  • 58
    • 0030945353 scopus 로고    scopus 로고
    • Phosphorylation of DNA polymerase α-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro
    • in press
    • Voitenleitner C, Fanning E, Nasheuer H-P: Phosphorylation of DNA polymerase α-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro. Oncogene 1997, in press.
    • (1997) Oncogene
    • Voitenleitner, C.1    Fanning, E.2    Nasheuer, H.-P.3
  • 59
    • 0027192941 scopus 로고
    • Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein
    • Jackson AL, Pahl PM, Harrison K, Rosamond J, Sclafani RA: Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol 1993, 13:2899-2908.
    • (1993) Mol Cell Biol , vol.13 , pp. 2899-2908
    • Jackson, A.L.1    Pahl, P.M.2    Harrison, K.3    Rosamond, J.4    Sclafani, R.A.5
  • 60
    • 0027978640 scopus 로고
    • Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
    • Dowell SJ, Romanowski P, Diffley JF: Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 1994, 265:1243-1246.
    • (1994) Science , vol.265 , pp. 1243-1246
    • Dowell, S.J.1    Romanowski, P.2    Diffley, J.F.3


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