Heparin is essential for a single keratinocyte growth factor molecule to bind and form a complex with two molecules of the extracellular domain of its receptor

Biochemistry

Volumn 38, Issue 8, 1999, Pages 2523-2534

  Hsu, Yueh Rong ^a   Nybo, Rebecca ^a   Sullivan, John K ^a   Costigan, Victoria ^a   Spahr, Christopher S ^a   Wong, Caroline ^a   Jones, Michael ^a   Pentzer, Andrea G ^a   Crouse, Jill A ^a   Pacifici, Robert E ^a   Lu, Hsieng S ^a   Morris, Charles F ^a   Philo, John S ^a,b  

^a AMGEN INC   (United States)

^b ALLIANCE PROTEIN LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; HEPARIN; KERATINOCYTE GROWTH FACTOR; RECEPTOR SUBTYPE;

ARTICLE; CHEMICAL REACTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DOSE RESPONSE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; REACTION ANALYSIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STOICHIOMETRY;

AMINO ACID SEQUENCE; CELL DIVISION; CELL LINE; CHROMATOGRAPHY, GEL; DIMERIZATION; DNA; EXTRACELLULAR SPACE; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GROWTH SUBSTANCES; HEPARIN; HUMANS; KERATINOCYTES; LIGHT; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, GROWTH FACTOR; SCATTERING, RADIATION; ULTRACENTRIFUGATION;

EID: 0033596726     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9821317     Document Type: Article

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