Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides: TBC3214, an ETa selective endothelin antagonist1

Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2001, Pages 1211-1216

  Wu, C ^a   Decker, R E ^a   Blok, N ^a   Li, J ^a   Bourgoyne, A R ^a   Bui, H ^a   Keller, K M ^a   Knowles, V ^a   Li, W ^a   Stavros, F D ^a   Holland, G W ^a   Brock, T A ^a   Dixon, R A F ^a  

^a TEXAS BIOTECHNOLOGY CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; SITAXSENTAN; SULFONAMIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HEART VENTRICLE HYPERTROPHY; IC 50; NONHUMAN; PULMONARY HYPERTENSION; RAT;

ADMINISTRATION, ORAL; ANILIDES; ANIMALS; BIOLOGICAL AVAILABILITY; CATS; DOGS; ISOXAZOLES; MODELS, MOLECULAR; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035848579     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000349x     Document Type: Article

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