Prediction of the intestinal absorption of endothelin receptor antagonists using three theoretical methods of increasing complexity

Pharmaceutical Research

Volumn 16, Issue 10, 1999, Pages 1520-1526

  Stenberg, Patric ^a   Luthman, Kristina ^b   Ellens, Harma ^c   Lee, Chao Pin ^c   Smith, Philip L ^c   Lago, Amparo ^c   Elliott, John D ^c   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF TROMSØ   (Norway)

^c NONE

Author keywords

Drug transport; Hydrogen bonding; Intestinal drug absorption; Molecular surface area; Rabbit colon

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ENDOTHELIN RECEPTOR ANTAGONIST; ENRASENTAN; SB 202994; SB 208601; SB 211835; SB 212314; SB 217585; SB 219730; SB 219862; SB 220501; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COLON ABSORPTION; DRUG ABSORPTION; DRUG CONFORMATION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG UPTAKE; HYDROGEN BOND; LIPID SOLUBILITY; MATHEMATICAL ANALYSIS; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; QUANTUM MECHANICS; RABBIT;

ANIMALS; BIOLOGICAL AVAILABILITY; CARBOXYLIC ACIDS; CHEMISTRY, PHYSICAL; COLON; HYDROGEN BONDING; INDANS; INTESTINAL ABSORPTION; MALE; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; PERMEABILITY; RABBITS; RECEPTORS, ENDOTHELIN; SOLUBILITY; SURFACE PROPERTIES;

EID: 0032729578     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015092201811     Document Type: Article

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