NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor

Journal of Molecular Biology

Volumn 311, Issue 2, 2001, Pages 341-356

  Kurniawan, Nyoman D ^a   Aliabadizadeh, Khosrow ^a   Brereton, Ian M ^a   Kroon, Paulus A ^a   Smith, Ross ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

15N backbone dynamics; Calcium binding EGF like modules; EGF structure; LDL receptor; NMR spectroscopy

Indexed keywords

CALCIUM ION; CYSTEINE; EPIDERMAL GROWTH FACTOR; LOW DENSITY LIPOPROTEIN RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CALCIUM BINDING; CELL SURFACE; DISULFIDE BOND; ENDOCYTOSIS; FAMILIAL HYPERCHOLESTEROLEMIA; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

ESCHERICHIA COLI;

EID: 0035839042     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4867     Document Type: Article

References (80)

1. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system
2. A receptor-mediated pathway for cholesterol homeostasis
3. LDL-receptor structure: Calcium cages, acid baths and recycling receptors
4. Cassette of eight exons shared by genes for LDL receptor and EGF precursor
5. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
6. An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components
7. Mutational analysis of the ligand binding domain of the low density lipoprotein receptor
8. Functional domains of the very low density lipoprotein receptor: Molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms
9. Structural requirements for Notch signalling with delta and Serrate during the development and patterning of the wing disc of Drosophila
10. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
11. Epidermal growth factor-like modules
12. Calcium-binding EGF-like modules in coagulation proteinases: Function of the calcium ion in module interactions
13. The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern
14. Solution structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern
15. Structure of the Ca(2+)-free Gla domain sheds light on membrane binding of blood coagulation proteins
16. Solution structure of the N-terminal EGF-like domain from human factor VII
17. The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X
18. Folding, calcium binding, and structural characterization of a concatemer of the first and second ligand-binding modules of the low-density lipoprotein receptor
19. AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR
20. Rotational diffusion anisotropy of human ubiquitin from 15N NMR relaxation
21. Backbone dynamics of Escherichia coli ribonuclease HI: Correlations with structure and function in an active enzyme
22. A test of the model-free formulas. Effects of anisotropic rotational diffusion and dimerization
23. Characterisation of the EGF-like module pair 3-4 from vitamin K-dependent protein S using NMR spectroscopy reveals dynamics on three separate time scales and extensive effects from calcium binding
24. EGF-like module pair 3-4 in vitamin K-dependent protein S: Modulation of calcium affinity of module 4 by module 3, and interaction with factor X
25. EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1
26. The first EGF domain of the LDL receptor contains a non-canonical calcium binding site
27. Backbone dynamics of cbEGF domain pair in the presence of calcium
28. Solution structure of a pair of calcium-binding epidermal growth factor-like domains: Implications for the marfan syndrome and other genetic disorders
29. Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
30. High-resolution solution structure of the EGF-like domain of heregulin-α
31. Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family
32. Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints
33. Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant
34. Crystal structure of active site-inhibited human coagulation factor VIIa (Des-Gla)
35. 2+-binding epidermal growth factor-like domain: Its role in protein-protein interactions
36. X-ray structure of clotting factor IXa: Active site and module structure related to Xase activity and hemophilia B
37. Coagulation factor IXa: The relaxed conformation of Tyr99 blocks substrate binding
38. Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein
39. Calcium is essential for the structural integrity of the cysteine-rich, ligand-binding repeat of the low-density lipoprotein receptor
40. Structural independence of ligand-binding modules five and six of the LDL-receptor
41. Molecular basis of familial hypercholesterolemia from structure of LDL receptor module
42. NMR structure of a concatemer of the first and second ligand-binding modules of the human low-density lipoprotein receptor
43. Backbone dynamics of a module pair from the ligand-binding domain of the LDL receptor
44. Novel mutations in the LDL receptor gene of Dutch familial hypercholesterolemic patients
45. Analysis of LDL receptor gene mutations in Italian patients with homozygous familial hypercholesterolemia
46. The LDL receptor locus in familial hypercholesterolemia: Mutational analysis of a membrane protein
47. LDLR database (second edition): New additions to the database and the software, and results of the first molecular analysis
48. Molecular genetics of familial hypercholesterolaemia in Norway
49. Phenotypic variation in heterozygous familial hypercholesterolemia: A comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada
50. Disulfide structures of highly bridged peptides: A new strategy for analysis
51. Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy
52. Practical aspects of 3D heteronuclear NMR of proteins
53. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
54. Investigation of exchange process by two-dimensional NMR spectroscopy
55. Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions
56. Gradient-tailored water suppression for H-1-N-15 HSQC experiments optimized to retain full sensitivity
57. 1H spectra of proteins via double quantum filtering
58. Rapid-pulsing artefacts in double-quantum-filtered COSY
59. 15N-enriched proteins
60. 15N inverse-detected heteronuclear NMR-spectroscopy - Application to staphylococcal nuclease
61. 15N NMR relaxation
62. 1H groups with pulsed-field gradients and preservation of coherence pathways
63. Torsion angle dynamics for NMR structure calculation with the new program DYANA
64. 1H nuclear magnetic resonance and distance geometry
65. Positive φ-angles in proteins by nuclear magnetic resonance spectroscopy
66. Three-dimensional structure of Escherichia coli periplasmic cyclophilin
67. Determination of three-dimensional structures of proteins and nucleic acids in solution by nuclear magnetic resonance spectroscopy
68. CHARMM: A program for macromolecular energy, minimization, and molecular dynamics calculations
69. MOLMOL: A program for display and analysis of macromolecular structures
70. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
71. HYDRONMR: Prediction of NMR relaxation of globular proteins from atomic-level structures and hydrodynamic calculations
72. Efficient analysis of macromolecular rotational diffusion from heteronuclear relaxation data
73. 1. Model-free approach to the interpretation of nuclear magnetic-resonance relaxation in macromolecules. 2. Analysis of experimental results
74. Nuclear spin relaxation in ellipsoids undergoing rotational Brownian motion
75. 15N NMR relaxation measurements at two magnetic fields
76. Rotational diffusion anisotropy and local backbone dynamics of carbon monoxide-bound Rhodobacter capsulatus cytochrome c′
77. 15N chemical-shift anisotropy from quantitative measurement of relaxation interference effects