Design and synthesis of potent hexapeptide and heptapeptide gonadotropin-releasing hormone antagonists by truncation of a decapeptide analogue sequence

Journal of Medicinal Chemistry

Volumn 43, Issue 15, 2000, Pages 2831-2836

  Yahalom, Dror ^a   Rahimipour, Shai ^a   Koch, Yitzhak ^a   Ben Aroya, Nurit ^a   Fridkin, Mati ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; HEPTAPEPTIDE; HEXAPEPTIDE; PEPTIDE DERIVATIVE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOLECULAR RECOGNITION; NONHUMAN; PEPTIDE SYNTHESIS; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; FEMALE; GONADOTROPIN-RELEASING HORMONE; LUTEINIZING HORMONE; MASS SPECTROMETRY; OLIGOPEPTIDES; PITUITARY GLAND; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034721171     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990433g     Document Type: Article

References (28)

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