Detection of higher-order 50- and 10-kbp DNA fragments before apoptotic internucleosomal cleavage after transient cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 4, 1997, Pages 376-387

  MacManus, John P ^a   Rasquinha, Ingrid ^a   Tuor, Ursala ^a   Preston, Edward ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Apoptosis; ischemia DNA fragmentation; Stroke

Indexed keywords

DNA FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN NECROSIS; CONTROLLED STUDY; DNA DEGRADATION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE; THYMOCYTE; TRANSIENT ISCHEMIC ATTACK;

EID: 0030991370     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199704000-00003     Document Type: Article

References (65)

1. Alnemri ES, Litwack G (1990) Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. J Biol Chem 28:17,323-17,333
2. Barry MA, Eastman A (1993) Identification of deoxyribonuclease-II as an endonuclease involved in apoptosis. Arch Biochim Biophys 300:440-450
3. Beere HM, Chresta CM, Alejo-Herberg A, et al. (1995) Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis. Mol Pharmacol 47:986-996
4. Bicknell GR, Cohen GM (1995) Cleavage of DNA to large kilobase pair fragments occurs in some forms of necrosis as well as apoptosis. Biochem Biophys Res Commun 207:40-47
5. Bortner CD, Oldenburg NBE, Cidlowski JA (1995) The role of DNA fragmentation in apoptosis. Trends Cell Biol 5:21-26
6. Brown DG, Sun XM, Cohen GM (1993) Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 28:3037-3039
7. Buja LM, Eigenbrodt ML, Eigenbrodt EH (1993) Apoptosis and necrosis: basic types and mechanisms of cell death. Arch Pathol Lab Med 117:1208-1214
8. Charriaut-Marlangue C, Margaill I, Plotkine M, Ben-Ari Y (1995) Early endonuclease activation following reversible focal ischemia in the rat brain. J Cereb Blood Flow Metab 15:385-388
9. Charriaut-Marlangue C, Aggoun-Zouaoui D, Represa A, Ben-Ari Y (1996a) Apoptotic features of selective neuronal death in ischemia, epilepsy and gp120 toxicity. Trends Neurosci 19:109-114
10. Charriaut-Marlangue C, Margaill I, Represa A, et al. (1996b) Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J Cereb Blood Flow Metab 16:186-194
11. Columbano A (1995) Cell death: current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J Cell Biochem 58:181-190
12. Cotman CW, Anderson AJ (1995) A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 10:19-45
13. Deckworth TL, Johnson EM (1993) Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J Cell Biol 123:1207-1222
14. Deshpande J, Bergstedt K, Linden T, Kalimo H, Wieloch T (1992) Ultrastructural changes in the hippocampus CA1 region following transient cerebral ischemia: evidence against programmed cell death. Exp Brain 88:91-105
15. Desjardins LM, MacManus JP (1995) An adherent cell model to study different stages of apoptosis. Exp Cell Res 216:380-387
16. Diana A, Setzu M, Sirigu S, Diaz G (1993) Nuclear patterns of apoptotic and developing neurons of superior cervical ganglion of newborn rat. Int J Dev Neurosci 11:773-780
17. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16:195-201
18. Ferrer I, Tortosa A, Macaya A, et al. (1994) Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil. Brain Pathol 4:115-122
19. Filipski J, Leblanc J, Youdale T, Sikorska M, Walker PR (1990) Periodicity of DNA folding in higher order chromatin structures. EMBO J 9:1319-1327
20. Fraser MJ (1994) Endo-exonuclease: enzymes involved in DNA repair and cell death? Bioessays 16:761-766
21. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501
22. Heron A, Pollard H, Dessi F, et al. (1993) Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain. J Neurochem 61:1973-1976
23. Hill IE, MacManus JP, Rasquinha I, Tuor U (1995) DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat. Brain Res 676:398-403
24. Ilschner SU, Waring P (1992) Fragmentation of DNA in the retina of chicken embryos coincides with retinal ganglion cell death. Biochem Biophys Res Commun 183:1056-1061
25. Iwai T, Hara A, Niwa M, et al. (1995) Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia. Brain Res 671:305-308
26. Kataoka A, Kubota M, Wakazono Y, et al. (1995) Association of high molecular weight DNA fragmentation with apoptotic and non-apoptotic cell death induced by calcium ionophore. FEBS Lett 364:264-267
27. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 237:57-69
28. Lagarkova MA, Iarovaia OV, Razin SV (1995) Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers. J Biol Chem 270:20,239-20,241
29. Li Y, Chopp M, Jiang N, Yao F, Zaloga C (1995a) Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397
30. Li Y, Sharov VG, Jiang N, Zaloga C, Sabbah HN, Chopp M (1995b) Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat. Am J Pathol 146:1045-1051
31. Li Y, Chopp M, Jiang N, Zaloga C (1995c) In situ detection of DNA fragmentation after focal cerebral ischemia in mice. Mol Brain Res 28:164-168
32. Linnik MD, Zobrist RH, Hatfield MD (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2009
33. Linnik MD, Miller JA, Sprinkle-Cavallo J, et al. (1995) Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion. Mol Brain Res 32:116-124
34. Lo AC Houenou LJ, Oppenheim RW (1995) Apoptosis in the nervous system: morphological features, methods, pathology and prevention. Arch Histol Cytol 58:139-149
35. MacManus JP, Buchan AM, Hill IE, Rasquinha I, Preston E (1993) Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 164:89-92
36. MacManus JP, Hill IE, Huang ZG, et al. (1994) DNA damage consistent with apoptosis in transient focal ischaemic neocortex. Neuro Report 5:493-496
37. MacManus JP, Hill IE, Preston E, et al. (1995a) Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats. J Cereb Blood Flow Metab 15:728-737
38. MacManus JP, Hill IE, Preston E, et al. (1995b) Neurodgeneration following cerebral ischemia exhibits some apoptotic components. J Cereb Blood Flow Metab 15(suppl 1):S404
39. Mitchell IJ, Lawson S, Moser B, et al. (1995) Glutamate-induced apoptosis results in a loss of striatal neurons in the Parkinsonian rat. Neuroscience 63:1-5
40. Montague JW, Gaido ML, Frye C, Cidlowski JA (1994) A calcium-dependent nuclease from apoptotic rat thymocytes in homologous with cyclophilin: recombinant cyclophilins A, B and C have nuclease activity. J Biol Chem 269:18,887-18,880
41. Nikonova LV, Beletsky IP, Umansky SR (1993) Properties of some nuclear nucleases of rat thymocytes and their changes in radiation-induced apoptosis. Eur J Biochem 215:893-901
42. Nitatori T, Sato N, Waguri S, et al. (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15: 1001-1011
43. Oberhammer F, Wilson JW, Dive C, et al. (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/ or 50 kbp fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12:3679-3684
44. Okamoto M, Matsumoto M, Ohtsuki T, et al. (1993) Internucleosomal DNA cleavage involved in ischemia-induced neuronal death. Biochem Biophys Res Commun 196:1356-1362
45. Peitsch MC, Polzar B, Stephan H, et al. (1993) Characterisation of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J 12:371-377
46. Pollard H, Cantagrel S, Charriault-Marlangue C, Moreau J, Ben-Ari Y (1994) Apoptosis associated DNA fragmentation in epileptic brain damage. Neuroreport 5:1053-1055
47. Schwartzman RA, Cidlowski JA (1991) Internucleosomal deoxyribonucleic acid cleavage activity in apoptotic thymocytes: detection and endocrine regulation. Endocrinology 128: 1190-1197
48. Sei Y, Von Lubitz DKJE, Basile AS, et al. (1994) Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia. Neurosci Lett 171:179-182
49. Siesjo BK (1988) Acisosis and ischemic brain damage. Neurochem Pathol 9:31-88.
50. Sloviter RS, Dean E, Neubort S (1993) Electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in adult central nervous system. J Comp Neurol 330:337-351
51. Stoler DL, Anderson GR, Russo CA, Spina AM, Beerman TA (1992) Anoxia-inducible endonuclease activity as a potential basis of genomic instability of cancer cells. Cancer Res 52:4372-4378
52. Sun XM, Cohen GM (1994) Mg-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis. J Biol Chem 269:14,857-14,860
53. Szabo G (1995) 50-kb chromatin fragmentation in the absence of apoptosis. Exp Cell Res 221:320-325
54. Thomas BL, Gates DJ, Richfield EK, et al. (1995) DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions. Exp Neurol 133:265-272
55. Tominaga T, Kure S, Narisawa K, Yoshimoto T (1993) Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 608:21-26
56. Torriglia A, Chaudun E, Chany-Fournier F, Jeanny JC, Courtois Y, Counis MF (1995) Involvement of DNase 11 in nuclear degeneration during lens cell differentiation. J Biol Chem 270:28,579-28,585
57. Tortosa A, Rivera R, Ferrer I (1994) Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia. J Neurosci 121:10-17
58. Ueda N, Walker PD, Hsu SM, Shah SV (1995) Activation of a 15-kDa endonuclease in hypoxia-reoxygenation injury without morphologic features of apoptosis. Proc Natl Acad Sci USA 92:7202-7206
59. Walker PR, Kokileva L, LeBlanc J, Sikorska M (1993) Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 15:1032-1040
60. Walker PR, Weaver VM, Lach B, LeBlanc J, Sikorska M (1994) Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis. Exp Cell Res 213:100-106
61. Walker PR, Pandey S, Sikorska M (1995) Degradation of chromatin in apoptotic cells. Cell Death Differ 2:97-104
62. Watanabe H, Kanbe K, Shinozaki T, Hoshino H, Chigira M (1995) Apoptosis of a fibroscarcoma induced by protein-free culture involves DNA cleavage to large fragments but not internucleosomal fragmentation. Int J Cancer 62:191-198
63. Wyllie AH, Kerr JFR, Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306
64. Zhivotovsky B, Wade D, Gahm A, Orrenius S, Nicotera P (1994a) Formation of 50 kb chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS Lett 351:150-154
65. Zhivotovsky B, Wade D, Nicotera P, Orrenhius S (1994b) Role of nucleases in apoptosis. Int Arch Allergy Immunol 105:333-338