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Volumn 59, Issue 3, 2000, Pages 401-410

What is new in the treatment of multiple sclerosis?

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BETA1A INTERFERON; CLADRIBINE; CYCLOPHOSPHAMIDE; GLATIRAMER; GLUCOCORTICOID; IMMUNOGLOBULIN; INTERFERON BETA SERINE; METHOTREXATE; METHYLPREDNISOLONE; MITOXANTRONE; RECOMBINANT INTERFERON;

EID: 0034048650     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200059030-00002     Document Type: Review
Times cited : (60)

References (43)
  • 1
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • 1. IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993: 655-61
    • (1993) Neurology , pp. 655-661
  • 2
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • 2. Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 1996; 39: 285-94
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 3
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis
    • 3. Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis (PRISMS) Study Group. Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Lancet 1998; 352 (9139): 1498-504
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1498-1504
  • 4
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey
    • 4. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996; 46: 907-11
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 5
    • 0030056764 scopus 로고    scopus 로고
    • Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis
    • 5. Lucchinetti CF, Bruck W, Rodriguez M, et al. Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 1996; 6: 259-74
    • (1996) Brain Pathol , vol.6 , pp. 259-274
    • Lucchinetti, C.F.1    Bruck, W.2    Rodriguez, M.3
  • 6
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transaction in the lesions of multiple sclerosis
    • 6. Trap BD, Peterson J, Ransohoff RM, et al. Axonal transaction in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278-85
    • (1998) N Engl J Med , vol.338 , pp. 278-285
    • Trap, B.D.1    Peterson, J.2    Ransohoff, R.M.3
  • 7
    • 0028936221 scopus 로고
    • The interferons: Biological effects mechanisms of action, and use in multiple sclerosis
    • 7. Weinstock-Guttman B, Ransohoff RM, Kinkel RP, et al. The interferons: biological effects mechanisms of action, and use in multiple sclerosis. Ann Neurol 1995; 37: 7-15
    • (1995) Ann Neurol , vol.37 , pp. 7-15
    • Weinstock-Guttman, B.1    Ransohoff, R.M.2    Kinkel, R.P.3
  • 8
    • 0008376732 scopus 로고    scopus 로고
    • Interferon beta in the treatment of multiple sclerosis: Mechanism of action
    • 8. Yong VW, Chabot S, Stuve O, et al. Interferon beta in the treatment of multiple sclerosis: mechanism of action. Neurology 1998; 51: 682-9
    • (1998) Neurology , vol.51 , pp. 682-689
    • Yong, V.W.1    Chabot, S.2    Stuve, O.3
  • 9
    • 0002078149 scopus 로고    scopus 로고
    • Structural analysis of human interferon beta (IFNβ): Studies addressing the activity differences between IFNβ-1a and IFNβ-1b
    • 9. Runkel L, Meier W, Pepinsky B, et al. Structural analysis of human interferon beta (IFNβ): studies addressing the activity differences between IFNβ-1a and IFNβ-1b [abstract P203]. Mult Scler 1997; 3: 337
    • (1997) Mult Scler , vol.3 , pp. 337
    • Runkel, L.1    Meier, W.2    Pepinsky, B.3
  • 10
    • 0030806739 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of interferon beta-1a in healthy volunteers after intravenous, subcutaneous and intramuscular administration
    • 10. Alam J, McAllister A, Scaramucci J, et al. Pharmacokinetics and pharmacodynamics of interferon beta-1a in healthy volunteers after intravenous, subcutaneous and intramuscular administration. Clin Drug Invest 1997; 14 (1): 35-43
    • (1997) Clin Drug Invest , vol.14 , Issue.1 , pp. 35-43
    • Alam, J.1    McAllister, A.2    Scaramucci, J.3
  • 11
    • 0031939494 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration
    • 11. Munafo A, Trinchard-Lugan I, Nguyen TXQ, et al. Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration. Eur J Neurol 1998; 5: 187-93
    • (1998) Eur J Neurol , vol.5 , pp. 187-193
    • Munafo, A.1    Trinchard-Lugan, I.2    Nguyen, T.X.Q.3
  • 12
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-controlled trial
    • 12. Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind, placebo-controlled trial. Neurology 1995; 45: 1268-76
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 13
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • 13. The IFNB Multiple Sclerosis Study Group, the UBC MS/MRI Analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 1995; 45: 1277-85
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 14
    • 6844250787 scopus 로고    scopus 로고
    • Magnetic resonance studies of intramuscular interferon-β-1a for relapsing multiple sclerosis
    • 14. Simon JH, Jacobs LD, Campion M, et al. Magnetic resonance studies of intramuscular interferon-β-1a for relapsing multiple sclerosis. Ann Neurol 1998; 43: 79-87
    • (1998) Ann Neurol , vol.43 , pp. 79-87
    • Simon, J.H.1    Jacobs, L.D.2    Campion, M.3
  • 15
    • 0032494792 scopus 로고    scopus 로고
    • European Study Group on interferon β-1b in secondary progressive MS. Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis
    • 15. European Study Group on Interferon β-1b in Secondary Progressive MS. Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998; 352: 1491-7
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 16
    • 0033544320 scopus 로고    scopus 로고
    • Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS: Multiple Collaborative Research Group
    • 16. Rudick RA, Fisher E, Lee JC, et al. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS: Multiple Collaborative Research Group. Neurology 1999; 53 (8): 1698-704
    • (1999) Neurology , vol.53 , Issue.8 , pp. 1698-1704
    • Rudick, R.A.1    Fisher, E.2    Lee, J.C.3
  • 17
    • 0023248694 scopus 로고
    • A pilot trial of cop 1 in exacerbating-remitting multiple sclerosis
    • 17. Bornstein MB, Miller AI, Slagle S, et al. A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N Engl J Med 1987; 317: 408-14
    • (1987) N Engl J Med , vol.317 , pp. 408-414
    • Bornstein, M.B.1    Miller, A.I.2    Slagle, S.3
  • 18
    • 6844254570 scopus 로고    scopus 로고
    • Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability: Copolymer I Multiple Sclerosis Study Group
    • 18. Johnson KP, Brooks BR, Cohen JA, et al. Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability: Copolymer I Multiple Sclerosis Study Group. Neurology 1998; 50 (3): 701-8
    • (1998) Neurology , vol.50 , Issue.3 , pp. 701-708
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 19
    • 0000093080 scopus 로고    scopus 로고
    • The effect of glatiramer acetate (Copaxone®) on disease activity as measured by cerebral MRI in patients with relapsing-remitting multiple sclerosis: A multi-center randomized, double-blind placebo-controlled study extended by open-label treatment
    • 19. Comi G, Filippi M, the Copaxone MRI study group. The effect of glatiramer acetate (Copaxone®) on disease activity as measured by cerebral MRI in patients with relapsing-remitting multiple sclerosis: a multi-center randomized, double-blind placebo-controlled study extended by open-label treatment. Neurology 1999; 52: A289
    • (1999) Neurology , vol.52
    • Comi, G.1    Filippi, M.2
  • 20
    • 0031057970 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis: Austrian Immunoglobulin in Multiple Sclerosis Study Group
    • 20. Fazekas F, Deisenhammer F, Strasser FS, et al. Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis: Austrian Immunoglobulin in Multiple Sclerosis Study Group. Lancet 1997; 349: 589-93
    • (1997) Lancet , vol.349 , pp. 589-593
    • Fazekas, F.1    Deisenhammer, F.2    Strasser, F.S.3
  • 21
    • 0031911494 scopus 로고    scopus 로고
    • Intravenous immunoglobulin treatment in multiple sclerosis: Effect on relapses
    • 21. Achiron A, Gabbay U, Gilad R, et al. Intravenous immunoglobulin treatment in multiple sclerosis: effect on relapses. Neurology 1998; 50: 398-402
    • (1998) Neurology , vol.50 , pp. 398-402
    • Achiron, A.1    Gabbay, U.2    Gilad, R.3
  • 22
    • 0031844370 scopus 로고    scopus 로고
    • Intravenous immunoglobulin G reduces MRI activity in relapsing multiple sclerosis
    • 22. Sorensen PS, Wanscher B, Jensen CV, et al. Intravenous immunoglobulin G reduces MRI activity in relapsing multiple sclerosis. Neurology 1998; 50: 1273-81
    • (1998) Neurology , vol.50 , pp. 1273-1281
    • Sorensen, P.S.1    Wanscher, B.2    Jensen, C.V.3
  • 23
    • 0025986898 scopus 로고
    • Overview of azathioprine treatment in multiple sclerosis
    • 23. Yudkin PL, Ellison GW, Ghezzi A, et al. Overview of azathioprine treatment in multiple sclerosis. Lancet 1991; 38: 1051-5
    • (1991) Lancet , vol.38 , pp. 1051-1055
    • Yudkin, P.L.1    Ellison, G.W.2    Ghezzi, A.3
  • 24
    • 0031665071 scopus 로고    scopus 로고
    • Devic's neuromyelitis optica: A prospective study of seven patients treated with prednisone and azathioprine
    • 24. Mandler RN, Ahmed W, Dencoff JE. Devic's neuromyelitis optica: a prospective study of seven patients treated with prednisone and azathioprine. Neurology 1998; 51: 1219-20
    • (1998) Neurology , vol.51 , pp. 1219-1220
    • Mandler, R.N.1    Ahmed, W.2    Dencoff, J.E.3
  • 25
    • 0013655667 scopus 로고    scopus 로고
    • ERAZISMUS: Early azathioprine versus beta-interferon treatment in multiple sclerosis: Results of a pilot safely study
    • Jun 5-9; Milan
    • 25. Morcau T, Blanc S, Riche G, et al. ERAZISMUS: Early Azathioprine versus Beta-Interferon Treatment in Multiple Sclerosis: results of a pilot safely study [abstract]. The 9th Annual Meeting of the European Neurological Society: 1999 Jun 5-9; Milan, 143
    • (1999) The 9th Annual Meeting of the European Neurological Society , pp. 143
    • Morcau, T.1    Blanc, S.2    Riche, G.3
  • 26
    • 0028906384 scopus 로고
    • Low-dose (7.5mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis
    • 26. Goodkin DE, Rudick RA, VanderBrug Medendorp S, at al. Low-dose (7.5mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis. Ann Neurol 1995; 37: 30-40
    • (1995) Ann Neurol , vol.37 , pp. 30-40
    • Goodkin, D.E.1    Rudick, R.A.2    VanderBrug Medendorp, S.3
  • 27
    • 0000793892 scopus 로고    scopus 로고
    • Mitoxantrone in progressive multiple sclerosis: A placebo-controlled, randomized, observer-blind phase III trial: Clinical results and three-year follow-up
    • 27. Hartung HP, Gonsette R, the MIMS-Study Group. Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, randomized, observer-blind phase III trial: clinical results and three-year follow-up [abstract]. Neurology 1999; 52: A290
    • (1999) Neurology , vol.52
    • Hartung, H.P.1    Gonsette, R.2
  • 28
    • 0028264426 scopus 로고
    • Cladribine in treatment of chronic progressive multiple sclerosis
    • 28. Sipe JC, Romine JS, Zozloi JA, et al. Cladribine in treatment of chronic progressive multiple sclerosis. Lancet 1994; 344: 9-13
    • (1994) Lancet , vol.344 , pp. 9-13
    • Sipe, J.C.1    Romine, J.S.2    Zozloi, J.A.3
  • 29
    • 0001593935 scopus 로고    scopus 로고
    • Results of the 3-year, double blind, placebo-controlled study of interferon beta 1a (Rebif) in secondary-progressive multiple sclerosis
    • Jun 5-9; Milan
    • 29. Patty D. Results of the 3-year, double blind, placebo-controlled study of interferon beta 1a (Rebif) in secondary-progressive multiple sclerosis. The 9th Annual Meeting of the European Neurological Society: 1999 Jun 5-9; Milan
    • (1999) The 9th Annual Meeting of the European Neurological Society
    • Patty, D.1
  • 30
    • 0029854588 scopus 로고    scopus 로고
    • Low-dose oral methotrexate in chronic progressive multiple sclerosis: Analysis of serial MRIs
    • 30. Goodkin DK, Rudick RA, VanderBrug Medendorp S. Low-dose oral methotrexate in chronic progressive multiple sclerosis: analysis of serial MRIs. Neurology 1996; 47: 1153-7
    • (1996) Neurology , vol.47 , pp. 1153-1157
    • Goodkin, D.K.1    Rudick, R.A.2    VanderBrug Medendorp, S.3
  • 31
    • 0020683886 scopus 로고
    • Intensive immunosuppression in progressive multiple sclerosis: A randomized, three arm study of high-dose intravenous cyclophosphamide, plasma exchange and ACTH
    • 31. Hauser SL, Dawson DM, Lehrich JR, et al. Intensive immunosuppression in progressive multiple sclerosis: a randomized, three arm study of high-dose intravenous cyclophosphamide, plasma exchange and ACTH. N Engl J Med 1983; 308: 173-80
    • (1983) N Engl J Med , vol.308 , pp. 173-180
    • Hauser, S.L.1    Dawson, D.M.2    Lehrich, J.R.3
  • 32
    • 0027196941 scopus 로고
    • Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: Final report of the Northeast Cooperative Multiple Sclerosis Treatment Group
    • 32. Weiner HL, Mackin GA, Orav EJ, et al. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology 1993; 43 (5): 910-8
    • (1993) Neurology , vol.43 , Issue.5 , pp. 910-918
    • Weiner, H.L.1    Mackin, G.A.2    Orav, E.J.3
  • 33
    • 0025967752 scopus 로고
    • The canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis
    • 33. The Canadian Cooperative Multiple Sclerosis Group. The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. Lancet 1991; 337: 441-6
    • (1991) Lancet , vol.337 , pp. 441-446
  • 34
    • 0001430776 scopus 로고    scopus 로고
    • Treatment of fulminant multiple sclerosis with intravenous cyclophosphamide
    • 34. Weinstock-Guttman B, Kinkel RP, Cohen JA, et al. Treatment of fulminant multiple sclerosis with intravenous cyclophosphamide. Neurologist 1997; 3: 178-85
    • (1997) Neurologist , vol.3 , pp. 178-185
    • Weinstock-Guttman, B.1    Kinkel, R.P.2    Cohen, J.A.3
  • 35
    • 8044242916 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome
    • 35. Millefiorini E, Gasperini C, Pozzilli C, et al. Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome. J Neurol 1997; 244: 153-9
    • (1997) J Neurol , vol.244 , pp. 153-159
    • Millefiorini, E.1    Gasperini, C.2    Pozzilli, C.3
  • 36
    • 0032908474 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis
    • 36. Romine JS, Sipe JC, Koziol JA, et al. A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis. Proc Assoc Am Physicians 1999; 111: 35-44
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 35-44
    • Romine, J.S.1    Sipe, J.C.2    Koziol, J.A.3
  • 37
    • 85038042557 scopus 로고    scopus 로고
    • Assessment of Mylinax™ (cladribine) in patients with progressive MS: Subgroup analysis of a phase III multicenter trial
    • 37. Rovaris M, Filippi M, Mastronardo G, et al. Assessment of Mylinax™ (cladribine) in patients with progressive MS: subgroup analysis of a phase III multicenter trial [abstract]. Neurology 1999; 52: A291
    • (1999) Neurology , vol.52
    • Rovaris, M.1    Filippi, M.2    Mastronardo, G.3
  • 38
    • 0022633684 scopus 로고
    • High dose intravenous methylprednisolone in the treatment of multiple sclerosis: Clinical-immunologic correlations
    • 38. Durelli L, Cocito D, Riccio A. High dose intravenous methylprednisolone in the treatment of multiple sclerosis: clinical-immunologic correlations. Neurology 1986; 36: 238-43
    • (1986) Neurology , vol.36 , pp. 238-243
    • Durelli, L.1    Cocito, D.2    Riccio, A.3
  • 39
    • 0032544590 scopus 로고    scopus 로고
    • Glucocorticosteroid therapy for multiple sclerosis: A critical review
    • 39. Andersson PB, Goodkin DE. Glucocorticosteroid therapy for multiple sclerosis: a critical review. J Neurol Sci 1998; 160: 16-25
    • (1998) J Neurol Sci , vol.160 , pp. 16-25
    • Andersson, P.B.1    Goodkin, D.E.2
  • 40
    • 0030995211 scopus 로고    scopus 로고
    • Randomized trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis
    • 40. Barnes D, Hughes RAC, Morris R, et al. Randomized trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis. Lancet 1997; 349: 902-6
    • (1997) Lancet , vol.349 , pp. 902-906
    • Barnes, D.1    Hughes, R.A.C.2    Morris, R.3
  • 41
    • 0027515341 scopus 로고
    • The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis
    • 41. Beck RW, Cleary PA, Trobe J, et al. The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. N Engl J Med 1993; 329: 1764-9
    • (1993) N Engl J Med , vol.329 , pp. 1764-1769
    • Beck, R.W.1    Cleary, P.A.2    Trobe, J.3
  • 42
    • 0031817597 scopus 로고    scopus 로고
    • A phase II study of IV methylprednisolone in secondary-progressive multiple sclerosis
    • 42. Goodkin DE, Kinkel RP, Weinstock-Guttman B, et al. A phase II study of IV methylprednisolone in secondary-progressive multiple sclerosis. Neurology 1998; 51: 239-45
    • (1998) Neurology , vol.51 , pp. 239-245
    • Goodkin, D.E.1    Kinkel, R.P.2    Weinstock-Guttman, B.3
  • 43
    • 0013634910 scopus 로고    scopus 로고
    • US MS society urges early drug treatment
    • Oct 23
    • 43. US MS society urges early drug treatment. Scrip 1998 Oct 23; 2381: 21
    • (1998) Scrip , vol.2381 , pp. 21


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