Oxazolidinones Mechanism of Action: Inhibition of the First Peptide Bond Formation

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37199-37205

  Patel, Utpal ^b   Yan, Yong P ^b   Hobbs Jr , Frank W ^b   Kaczmarczyk, Janet ^b   Slee, Andrew M ^b   Pompliano, David L ^b   Kurilla, Michael G ^b   Bobkova, Ekaterina V ^a  

^a DUPONT COMPANY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOSYNTHESIS; PROTEINS; RNA; SUBSTRATES;

BACTERIAL PROTEIN BIOSYNTHESIS;

BIOCHEMISTRY;

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CCA PHENYLALANINE; FORMYLMETHIONYL TRANSFER RIBONUCLEIC ACID; LINEZOLID; N [[3 (4 ACETYLPHENYL) 2 OXO 5 OXAZOLIDINYL]METHYL]ACETAMIDE; OXAZOLIDINONE DERIVATIVE; PEPTIDYLTRANSFERASE; PHENYLALANINE DERIVATIVE; POLYURIDYLIC ACID; PUROMYCIN; TRANSFER RNA; UNCLASSIFIED DRUG; XA 043; MESSENGER RNA; PROTEIN SYNTHESIS INHIBITOR;

70S RIBOSOME SUBUNIT; A SITE SUBSTRATE; ARTICLE; BINDING SITE; CHEMICAL BOND; COMPETITIVE INHIBITION; COMPLEX FORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; P SITE SUBSTRATE; PEPTIDE BOND; POLYSOME; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; RIBOSOME SUBUNIT; RNA TRANSLATION; STEADY STATE; DRUG ANTAGONISM; DRUG INTERACTION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; PEPTIDE SYNTHESIS; PROTEIN SYNTHESIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

DRUG INTERACTIONS; ESCHERICHIA COLI; KINETICS; OXAZOLIDINONES; PEPTIDE BIOSYNTHESIS; PEPTIDYL TRANSFERASES; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; PUROMYCIN; RNA, MESSENGER;

EID: 0035813105     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102966200     Document Type: Article

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