Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: Characterization of the apoptotic death

Cell Death and Differentiation

Volumn 4, Issue 2, 1997, Pages 95-104

  McGahon, Anne J ^a   Brown, David G ^b   Martin, Seamus J ^a   Amarante Mendes, Gustavo P ^a   Cotter, Thomas G ^c   Cohen, Gerald M ^b   Green, Douglas R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Antisense; Apoptosis; Bcr Abl; DNA fragmentation

Indexed keywords

BCR ABL PROTEIN; DNA FRAGMENT;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN K 562; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; GEL ELECTROPHORESIS; GENE FUSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOSOME; ONCOGENE; PRIORITY JOURNAL;

EID: 0031055620     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400213     Document Type: Article

References (35)

1. Amos TAS, Lewis JL, Grand FH, Gooding RP, Goldman JM and Gordon MY (1995) Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids. Br. J. Haematol. 91: 387-393
2. Bedi A, Zehnbauer A, Barber J, Sharkis S and Jones RJ (1994) Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 83: 2038-2044
3. Bedi A, Barber JP, Bedi GC, Wafik SED, Sidransky D, Vala MS, Akhtar AJ, Hilton J and Jones RJ (1995) BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistnace to multiple anticancer agents. Blood 86: 1148-1158
4. Bortner CD, Oldenburg NBE and Cidlowski JA (1995) The role of DNA fragmentation in apoptosis. Trends Cell Biol. 5: 21-26
5. Brown DG, Sun XM and Cohen GM (1993) Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J. Biol. Chem. 268: 3037-3039
6. Carlesso N, Griffin JD and Druker BJ (1994) Use of a temperature sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene 1: 149-156
7. Chapman RS, Whetton AD and Dive C (1994) The suppression of drug-induced apoptosis by activation of the v-Abl protein tyrosine kinase. Cancer Res. 54: 5131-5137
8. Cohen GM, Sun XM, Fearnhead H, MacFarlane M, Brown DG, Snowdon RT and Dinsdale D (1994) Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol. 153: 507-516
9. Cohen GM, Sun XM, Snowden RT, Dinsdale D and Skilleter DN (1992) Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 286: 331-334
10. Cohen JJ, Duke RC, Fadok VA and Sellins KS (1992) Apoptosis and programmed cell death in immunity. Ann. Rev. Immunol. 10: 267-293
11. Compton MM (1992) A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev. 11: 105-119
12. Cotter TG, Glynn JM, Echeverri F and Green DR (1992) The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. Anticancer Res. 12: 773-780
13. Dormer P, Lau B and Wilmanns W (1980) Kinetics of bone marrow cell production in human acute and chronic myeloid leukemias. Leuk. Res. 4: 231-237
14. Evans CA, Owen-Lynch PJ, Whetton AD and Dive C (1993) Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoeitic cells. Cancer Res. 53: 1735-1738
15. Evans CA, Lord JM, Owen-Lynch PJ, Johnson G, Dive C and Whetton AD (1995) Suppression of apoptosis by v-Abl protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interteukin-3-dependent haemopoietic cell line. J Cell Sci. 108: 2591-2598
16. Fernandes RC and Cotter TG (1993) Activation of a calcium magnesium independent endonuclease in human leukemic cell apoptosis. Anticancer Res. 13: 1253-1258
17. Gorczyca W, Darzynkiewicz RJ, Gong J and Darzynkiewicz Z (1992) DNA strand breaks occurring during apoptosis: Their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays, and prevention by serine protease inhibitors. Int. J. Oncol. 1: 639-648
18. Green DR, Mahboubi A, Nishioka WN, Oja S, Echeverri F, Shi Y, Glynn J, Yang Y, Ashwell J and Bissonette RP (1994) Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals. Immun. Rev. 142: 321-342
19. Greenberg PL (1992) Programmed cell death (apoptosis) as a mechanism for regulating haematopoietic cell population size. Focus Growth Factors 3: 1-3
20. Groeffen J and Heisterkamp N (1987) The BCR/ABL hybrid gene. Chronic myeloid leukemia, J.M. Goldman (ed.) Bailliere Tindall London 983-999
21. Gromkowski ST, Brown TC, Cerutti PA and Cerottini JC (1986) DNA of human Raji target cells is damaged upon lymphocyte-mediated lysis. J. Immunol. 136: 752-756
22. Hariharan IK, Adams JM and Cory S (1989) A bcr-v-abl oncogene induces lymphomas in transgenic mice. Mol. Cell. Biol. 9: 2798-2805
23. Heisterkamp N, Jenster G, Hoeve J, Zovich D, Pattengale PK and Groeffen J (1990) Acute leukemia in bcr/abl transgenic mice. Nature 344: 251-253
24. Kerr JFR, Wyllie AH and Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257
25. Koeffler PH and Golde D (1981) Chronic Myelogenous Leukemia - New Concepts. N. Engl. J. Med. 304: 1201-1209
26. Konopka JB and Witte ON (1985) Activation of the ab/oncogene in murine and human leukemias. Biochem. Biophys. Acta 823: 1-17
27. Lennon SV, Martin SJ and Cotter TG (1991) Dose-dependent induction of apoptosis in human tumourcell lines by widely diverging stimuli. Cell Proliferation 24: 203-214
28. Lockshin R, Alles A, Kodaman N and Zakeri ZF (1991) Programmed cell death and apoptosis; early DNA degradation does not appear to be prominent in either embryonic cell death or metamorphosis of insects. FASEB J. 5: 518-525.
29. Martin SJ, Matear PM and Vyakamam A (1994) HIV infection of CD4+T cells in vitro: Differential induction of apoptosis in these cells. J. Immunol. 145: 1859-1867
30. Martin SJ, O'Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, Saido TC and Green DR (1995) Proteolysis of Fodrin (nonerythroid spectrin) during apoptosis. J. Biol. Chem. 270: 6425-6428
31. McGahon A, Bissonette RP, Schmitt M, Cotter K, Green DR and Cotter TG (1994) Bcr-Abl maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 83: 1179-1187
32. McGahon AJ, Martin SJ, Bissonette RP, Mahboubi A, Shi Y, Mogil RJ, Nishioka Wand Green DR (1995a) The end of the (cell) line: methods for the induction of apoptosis in vitro. Methods Cell Biol. 46: 153-185
33. McGahon A, Nishioka WK, Martin SJ, Mahboubi A, Cotter TG and Green DR (1995b) Regulation of the Fas apoptotic cell deth pathway by Abl. J. Biol. Chem. 270: 22625-22631
34. McLaughlin J, Chianese E and Witte ON (1987) In vitro transformation of immature hemopoeitic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome. Proc. Natl. Acad. Sci. USA 84: 6558-6562
35. Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE and Sikorska M (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb prior to or in the absence of internucleosomal fragmentation. EMBO J. 12: 3679-3684