Coding in the granular layer of the cerebellum

Progress in Brain Research

Volumn 130, Issue , 2001, Pages 279-296

  De Schutter, Erik ^a   Bjaalie, Jan G ^b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CEREBELLUM; CEREBELLUM CORTEX; CONFERENCE PAPER; GRANULE CELL; HUMAN; INFORMATION PROCESSING; MODEL; MOSSY FIBER; NERVE CELL NETWORK; NEUROANATOMY; PONS; PRIORITY JOURNAL;

EID: 0035783784     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(01)30019-5     Document Type: Conference Paper

References (93)

1. Albus, J.S. (1971) A theory of cerebellar function. Math. Biosci., 10: 25-61.
2. Allen, G.I. and Tsukahara, N. (1974) Cerebrocerebellar communication systems. Physiol. Rev., 54: 957-1005.
3. Andersen, B.B., Korbo, L. and Pakkenberg, B. (1992) A quantitative study of the human cerebellum with unbiased stereological techniques. J. Comp. Neurol., 326: 549-560.
4. Bernard, C. and Axelrad, H. (1991) Propagation of parallel fiber volleys in the cerebellar cortex: A computer simulation. Brain Res., 565: 195-208.
5. Bjaalie, J.G. (1985) Distribution in areas 18 and 19 of neurons projecting to the pontine nuclei: A quantitative study in the cat with retrograde transport of HRP-WGA. Exp. Brain Res., 57: 585-597.
6. Bjaalie, J.G. (1986) Distribution of corticopontine neurons in visual areas of the middle suprasylvian sulcus: Quantitative studies in the cat. Neuroscience, 18: 1013-1033.
7. Bjaalie, J.G. and Brodal, P. (1983) Distribution in area 17 of neurons projecting to the pontine nuclei: A quantitative study in the cat with retrograde transport of HRP-WGA. J. Comp. Neurol., 221: 289-303.
8. Bjaalie, J.G., Sudbø, J. and Brodal, P. (1997) Corticopontine terminal fibres form small scale clusters and large scale lamellae in the cat. Neuroreport, 8: 1651-1655.
9. Border, B.G. and Mihailoff, G.A. (1990) GABAergic neural elements in the rat basilar pons: Electron microscopic immunochemistry. J. Comp. Neurol., 295: 123-135.
10. Bower, J.M., Beerman, D.H., Gibson, J.M., Shambes, G.M. and Welker, W. (1981) Principles of organization of a cerebrocerebellar circuit. Micromapping the projections from cerebral (SI) to cerebellar (granule cell layer) tactile areas of rats. Brain Behav. Evol., 18: 1-18.
11. Bower, J.M. (1997) Is the cerebellum sensory for motor's sake or motor for sensory's sake: The view from the whiskers of a rat? Prog. Brain Res., 114: 463-496.
12. Bower, J.M. and Kassel, J. (1990) Variability in tactile projection patterns to cerebellar folia crus IIA of the Norway rat. J. Comp. Neurol., 302: 768-778.
13. Bower, J.M. and Woolston, D.C. (1983) Congruence of spatial organization of tactile projections to granule cell and Purkinje cell layers of cerebellar hemispheres of the albino rat: Vertical organization of cerebellar cortex. J. Neurophysiol., 49: 745-766.
14. Braitenberg, V., Heck, D. and Sultan, F. (1997) The detection and generation of sequences as a key to cerebellar function. Experiments and theory. Behav. Brain Sci., 20: 229-245.
15. Brickley, S.G., Cull-Candy, S.G. and Farrant, M. (1996) Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J. Physiol., 497: 753-759.
16. Brodal, P. and Bjaalie, J.G. (1992) Organization of the pontine nuclei. Neurosci. Res., 13: 83-118.
17. Brodal, P., Mihailoff, G., Border, B., Ottersen, O.P. and StormMathisen, J. (1988) GABA-containing neurons in the pontine nuclei of rat, cat and monkey. An immunocytochemical study. Neuroscience, 25: 27-45.
18. Brumberg, J.C., Pinto, D.J. and Simons, D.J. (1996) Spatial gradients and inhibitory summation in the rat whisker barrel system. J. Neurophysiol., 76: 130-140.
19. Chapin, J.K. and Lin, C.-S. (1990) The somatic sensory cortex of the rat. In: B. Kolb and R.C. Tees (Eds.), The Cerebral Cortex of the Rat. MIT Press, Cambridge, MA, pp. 341-380.
20. Cobb, S.R., Buhl, E.H., Halasy, K., Paulsen, O. and Somogyi, P. (1995) Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature, 378: 75-78.
21. Cohen, D. and Yarom, Y. (1998) Patches of synchronized activity in the cerebellar cortex evoked by mossy-fiber stimulation: Questioning the role of parallel fibers. Proc. Natl. Acad. Sci. USA, 98: 15032-15036.
22. D'Angelo, E., De Filippi, G., Rossi, P. and Taglietti, V. (1995) Synaptic excitation of individual rat cerebellar granule cells in situ: Evidence for the role of NMDA receptors. J. Physiol., 482: 397-413.
23. D'Angelo, E., De Filippi, G., Rossi, P. and Taglietti, V. (1998) Ionic mechanism of electroresponsiveness in cerebellar granule cells implicates the action of a persistent sodium current. J. Neurophysiol., 80: 493-503.
24. D'Angelo, E., Rossi, P., Armano, S. and Taglietti, V. (1999) Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber-granule cell transmission in rat cerebellum. J. Neurophysiol., 81: 277-287.
25. De Schutter, E. (1995) Cerebellar long-term depression might normalize excitation of Purkinje cells: A hypothesis. Trends Neurosci., 18: 291-295.
26. De Schutter, E. (1997) A new functional role for cerebellar long term depression. Prog. Brain Res., 114: 529-542.
27. De Schutter, E. (1998) Dendritic voltage and calcium-gated channels amplify the variability of postsynaptic responses in a Purkinje cell model. J. Neurophysiol., 80: 504-519.
28. De Schutter, E. and Bower, J.M. (1994a) An active membrane model of the cerebellar Purkinje cell, I. Simulation of current clamps in slice. J. Neurophysiol., 71: 375-400.
29. De Schutter, E. and Bower, J.M. (1994b) An active membrane model of the cerebellar Purkinje cell, II. Simulation of synaptic responses. J. Neurophysiol., 71: 401-419.
30. De Schutter, E. and Maex, R. (1996) The cerebellum: Cortical processing and theory. Curr. Opin. Neurobiol., 6: 759-764.
31. De Schutter, E., Vos, B.P. and Maex, R. (2000) The function of cerebellar Golgi cells revisited. Prog. Brain Res., 124: 81-93.
32. De Zeeuw, C.I., Hansel, C., Bian, F., Koekkoek, S.K., van Alphen, A.M., Linden, D.J. and Oberdick, J. (1998) Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex. Neuron, 20: 495-508.
33. Dieudonné, S. (1998) Submillisecond kinetics and low efficacy of parallel fibre-Golgi cell synaptic currents in the rat cerebellum. J. Physiol., 510: 845-866.
34. Dieudonné, S. and Dumoulin, A. (2000) Serotonin-driven longrange inhibitory connections in the cerebellar cortex. J. Neurosci., 20: 1837-1848.
35. Dykes, R.W., Landry, P., Metherate, R. and Hicks, T.P. (1984) Functional role of GABA in cat primary somatosensory cortex: Shaping receptive fields of cortical neurons. J. Neurophysiol., 52: 1066-1093.
36. Eccles, J.C., Llinás, R.R. and Sasaki, K. (1966) The mossy fibre-granule cell relay of the cerebellum and its inhibitory control by Golgi cells. Exp. Brain Res., 1: 82-101.
37. Edgley, S.A. and Lidierth, M. (1987) The discharges of cerebellar Golgi cells during locomotion in the cat. J. Physiol., 392: 315-332.
38. Eilers, J., Takechi, H., Finch, E.A., Augustine, G.J. and Konnerth, A. (1997) Local dendritic Ca2+ signaling induces cerebellar long-term depression. Learn. Memory, 4: 159-168.
39. Eycken, A., Bjaalie, J.G., Volny-Luraghi, A. and De Schutter, E. (2000) Electrophysiology of the pontine nuclei in the anesthetized rat. Eur. J. Neurosci. Suppl., 11: 430.
40. Finch, E.A. and Augustine, G.J. (1998) Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature, 396: 753-756.
41. Franck, P.R.C.A., Maex, R. and De Schutter, E. (2001) Synchronization between patches of local excitation in a cerebellar granular layer model. Neurocomputing., in press.
42. Geurts, F., Timmermans, J.-P. and De Schutter, E. (2001) Morphological and neurochemical differentiation of large granule layer interneurons in the adult rat cerebellum. Neuroscience, in press.
43. Gundappa-Sulur, G., De Schutter, E. and Bower, J.M. (1999) Ascending granule cell axon: An important component of the cerebellar cortical circuitry. J. Comp. Neurol., 408: 580-596.
44. Hartell, N.A. (1996) Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses. Neuron, 16: 601-610.
45. Hartmann, M.J. and Bower, J.M. (1998) Oscillatory activity in the cerebellar hemispheres of unrestrained rats. J. Neurophysiol., 80: 1598-1604.
46. Harvey, R.J. and Napper, R.M.A. (1991) Quantitative studies of the mammalian cerebellum. Prog. Neurobiol., 36: 437-463.
47. Hopfield, J.J. (1995) Pattern recognition computation using action potential timing for stimulus representation. Nature, 376: 33-36.
48. Ito, M. (1982) Cerebellar control of the vestibulo-ocular reflex - Around the flocculus hypothesis. Annu. Rev. Neurosci., 5: 275-298.
49. Ito, M. (1984) The Cerebellum and Neural Control. Raven Press, New York.
50. Jaeger, D. and Bower, J.M. (1999) Synaptic control of spiking in cerebellar Purkinje cells: Dynamic current clamp based on model conductances. J. Neurosci., 19: 6090-6101.
51. Jaeger, D., De Schutter, E. and Bower, J.M. (1997) The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: A modeling study. J. Neurosci., 17: 91-106.
52. Korbo, L., Andersen, B.B., Ladefoged, O. and Møller, A. (1993) Total numbers of various cell types in rat cerebellar cortex estimated using an unbiased stereological method. Brain Res., 609: 262-268.
53. Leergaard, T.B. and Bjaalie, J.G. (1998) From cortical 2-D to brain stem 3-D maps: Organisation of corticopontine projections in developing and adult rats. Abstr. Soc. Neurosci., 24: 262.9.
54. Leergaard, T.B., Lakke, E.A.J.F. and Bjaalie, J.G. (1995) Topographical organization in the early postnatal corticopontine projection. A carbocyanine dye and 3-D computer reconstruction study in the rat. J. Comp. Neurol., 361: 77-94.
55. Leergaard, T.B., Lyngstad, K.A., Thompson, J.H., Taeymans, S., Vos, B.P., De Schutter, E., Bower, J.M. and Bjaalie, J.G. (2000a) Rat somatosensory cerebro-ponto-cerebellar pathways: Spatial relationships in the SI somatotopic map are preserved in a three-dimensional clustered pontine map. J. Comp. Neurol., 422: 246-266.
56. Leergaard, T.B., Alloway, K.D., Mutic, J.J. and Bjaalie, J.G. (2000b) Three-dimensional topography of corticopontine projections from rat barrel cortex: Correlations with corticopontine organization. J. Neurosci., 20: 8474-8484.
57. Linden, D.J. and Connor, J.A. (1995) Long-term synaptic depression. Annu. Rev. Neurosci., 18: 319-357.
58. Lytton, W.W. and Sejnowski, T.J. (1991) Simulations of cortical pyramidal neurons synchronized by inhibitory interneurons. J. Neurophysiol., 66: 1059-1079.
59. Maex, R. and De Schutter, E. (1998a) The critical synaptic number for rhythmogenesis and synchronization in a network model of the cerebellar granular layer. In: L. Niklasson, M. Bodén and T. Ziemke (Eds.), ICANN 98. Springer, London, pp. 361-366.
60. Maex, R. and De Schutter, E. (1998b) Synchronization of Golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. J. Neurophysiol., 80: 2521-2537.
61. Maex, R., Vos, B.P. and De Schutter, E. (2000) Weak common parallel fibre synapses explain the loose synchrony between rat cerebellar Golgi cells. J. Physiol., 523: 175-192.
62. Marr, D.A. (1969) A theory of cerebellar cortex. J. Physiol., 202: 437-470.
63. Mauk, M.D. (1997) Roles of cerebellar cortex and nuclei in motor learning: Contradictions or clues? Neuron, 18: 343-346.
64. Mihailoff, G.A., Kosinski, R.J., Azizi, S.A., Lee, H.S. and Border, B.G. (1992) The expanding role of the basilar pontine nuclei as a source of cerebellar afferents. In: R.R. Llinás and C. Sotelo (Eds.), The Cerebellum Revisited. Springer, Berlin, pp. 135-164.
65. Minsky, M. and Papert, S. (1969) Perceptrons: An Introduction to Computational Geometry. MIT Press, Cambridge, MA.
66. Morissette, J. and Bower, J.M. (1996) Contribution of somatosensory cortex to responses in the rat cerebellar cortex granule cell layer following peripheral tactile stimulation. Exp. Brain Res., 109: 240-250.
67. Mountcastle, V.B., Davies, P.W. and Berman, A.L. (1957) Response properties of neurons of cat's somatic sensory cortex to peripheral stimuli. J. Neurophysiol., 20: 374-407.
68. Murphy, J.T. and Sabah, N.H. (1971) Cerebellar Purkinje cell responses to afferent inputs, II. Mossy fiber activation. Brain Res., 25: 469-482.
69. Nelson, R.J., Sur, M., Felleman, D.J. and Kaas, J.H. (1980) Representations of the body surface in postcentral parietal cortex of Macaca fascicularis. J. Comp. Neurol., 192: 611-643.
70. Nicolelis, M.A.L. and Chapin, J.K. (1994) Spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterio medial nucleus of the thalamus. J. Neurosci., 14: 3511-3532.
71. Øverby, S.E., Bjaalie, J.G. and Brodal, P. (1989) Uneven densities of corticopontine neurons in the somatosensory cortex. A quantitative experimental study in the cat. Exp. Brain Res., 77: 653-665.
72. Palay, S.L. and Chan-Palay, V. (1974) Cerebellar Cortex. Springer, New York.
73. Peeters, R.R., Verhoye, M., Vos, B.P., Van Dyck, D., Van Der Linden, A. and De Schutter, E. (1999) A patchy horizontal organization of the somatosensory activation of the rat cerebellum demonstrated by functional MRI. Eur. J. Neurosci., 11: 2720-2730.
74. Pellerin, J.-P. and Lamarre, Y. (1997) Local field potential oscillations in primate cerebellar cortex during voluntary movement. J. Neurophysiol., 78: 3502-3507.
75. Pichitpornchai, C., Rawson, J.A. and Rees, S. (1994) Morphology of parallel fibers in the cerebellar cortex of the rat: An experimental light and electron microscopic study with biocytin. J. Comp. Neurol., 342: 206-220.
76. Raymond, J.L., Lisberger, S.G. and Mauk, M.D. (1996) The cerebellum: A neuronal learning machine?. Science, 272: 1126-1131.
77. Regan, L.J. (1991) Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis. J. Neurosci., 11: 2259-2269.
78. Rieke, E, Warland, D., de Ruyter van Steveninck, R.R. and Bialek, W. (1997) Spikes. Exploring the Neural Code. MIT Press, Cambridge, MA.
79. Schwarz, C. and Thier, P. (1999) Binding of signals relevant for action: Towards a hypothesis of the functional role of the pontine nuclei. Trends Neurosci., 22: 443-451.
80. Shambes, G.M., Gibson, J.M. and Welker, W. (1978) Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping. Brain Behav. Evol., 15: 94-140.
81. Steuber, V. and Willshaw, D.J. (1999) Adaptive leaky integrator models of cerebellar Purkinje cells can learn the clustering of temporal patterns. Neurocomputing, 26: 271-276.
82. Stuart, G. and Häusser, M. (1994) Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron, 13: 703-712.
83. Usowicz, M.M., Sugimori, M., Cherksey, B. and Llinás, R.R. (1992) Characterization of P-type calcium channels in cerebellar Purkinje cells. Abstr. Soc. Neurosci., 18: 974-974,
84. Van Kan, P.L.E., Gibson, A.R. and Houk, J.C. (1993) Movement-related inputs to intermediate cerebellum of the monkey. J. Neurophysiol., 69: 74-94.
85. Vassbø, K., Nicotra, G., Wiberg, M. and Bjaalie, J.G. (1999) Monkey somatosensory cerebro-cerebellar pathways: Uneven densities of corticopontine neurons in different body representations of areas 3b, 1, and 2. J. Comp. Neurol., 406: 109-128.
86. Volny-Luraghi, A., De Schutter, E. and Vos, B.P. (1999) Responses of cerebellar Golgi cells to tactile stimuli of different sizes. Abstr. Soc. Neurosci., 25: 914.
87. Voogd, J. and Glickstein, M. (1998) The anatomy of the cerebellum. Trends Neurosci., 21: 370-375.
88. Vos, B.P., Maex, R., Volny-Luraghi, A. and De Schutter, E. (1999a) Parallel fibers synchronize spontaneous activity in cerebellar Golgi cells. J. Neurosci., 19(RC6):1-5.
89. Vos, B.P., Volny-Luraghi, A. and De Schutter, E. (1999b) Cerebellar Golgi cells in the rat: Receptive fields and timing of responses to facial stimulation. Eur. J. Neurosci., 11: 2621-2634.
90. Vos, B.P., Taeymans, S., Wijnants, M. and De Schutter, E. (1999c) Miniature carrier with six independently moveable electrodes for recording of multiple single-units in the cerebellar cortex of awake rats. J. Neurosci. Methods, 94: 19-26.
91. Vos, B.P., Volny-Luraghi, A., Maex, R. and De Schutter, E. (2000) Precise spike timing of tactile-evoked cerebellar Golgi cell responses: A reflection of combined mossy fiber and parallel fiber activation? Prog. Brain Res., 124: 95-105.
92. Vranesic, I., Iijima, T., Ichikawa, M., Matsumoto, G. and Knöpfel, T. (1994) Signal transmission in the parallel fiber Purkinje cell system visualized by high-resolution imaging. Proc. Natl. Acad. Sci. USA, 91: 13014-13017.
93. Welker, W. (1987) Spatial organization of somatosensory projections to granule cell cerebellar cortex: Functional and connectional implications of fractured somatotopy (summary of Wisconsin studies). In: J.S. King (Ed.), New Concepts in Cerebellar Neurobiology. Alan R. Liss, New York, pp. 239-280.