Diinosine polyphosphates, a group of dinucleotides with antagonistic effects on diadenosine polyphosphate receptor

Molecular Pharmacology

Volumn 51, Issue 2, 1997, Pages 277-284

  Pintor, Jesús ^a   Gualix, Javier ^a   Miras Portugal, M Teresa ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE RECEPTOR; DIINOSINE POLYPHOSPHATE; DINUCLEOTIDE; PURINE P2 RECEPTOR; PURINE P4 RECEPTOR; PURINE RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL 5 PHOSPHATE; RECEPTOR SUBTYPE; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ASPERGILLUS; BRAIN CORTEX; BRAIN SYNAPTOSOME; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031017168     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.2.277     Document Type: Article

References (28)

1. xA) as new neurotransmitters. Drug Dev. Res. 28:259-262 (1993).
2. Klishin, A., N. Lozovaya, J. Pintor, M. T. Miras-Portugal, and O. Krishtal. Possible functional role of diadenosine polyphosphates: negative feedback for excitation in hippocampus. Neuroscience 58:235-236 (1994).
3. Stone, T. W., and M. N. Perkins. Adenine dinucleotide effect on rat cortical neurones. Brain Res. 229:241-245 (1981).
4. 2 purinoceptors for diadenosine polyphosphates in the nervous system. Gen. Pharmacol. 26:229-235 (1994).
5. Pintor, J., and M. T. Miras-Portugal. A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat brain synaptosomes. Br. J. Pharmacol. 115:895-902 (1995).
6. 2+ influx distinct from ATP mediated influx. J. Neurosci. Res. 44:478-489 (1996).
7. Fredholm, B. B., M. P. Abbraccio, G. Burnstock, J. W. Daly, T. K. Harden, K. Jacobson, P. Leff, and M. Williams. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 16:143-156 (1994).
8. 2-purinoceptors agonists purinergic nerve stimulation in the guinea-pig urinary bladder and Taenia coli. Br. J. Pharmacol. 99:617-621 (1990).
9. 2-purinoceptor properties of pyridoxal-5-phosphate. Eur. J. Pharmacol. 259:295-300 (1994).
10. Ziganshin, A. U., C. H. V. Hoyle, X. Bo, G. Lambrech, E. Mutscher, H. G. Baumert, and G. Burnstock. PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol. 110:1491-1495 (1993).
11. Guranowski, A., E. Starzynska, M. A. Günther Sillero, and A. Sillero. Conversion of adenosine(5′)oligophospho(5′) adenosines into inosine(5′)oligophospho (5′) inosines by non-specific adenylate deaminase from the snail Helix pomatia. Biochim. Biophys. Acta 1243:78-84 (1995).
12. 2+ dependent release evoked by 4-aminopyridine and veratridine. Neurosci. Lett. 136:141-144 (1992).
13. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450 (1985).
14. 2 values and associated analysis. J. Pharmacol. Exp. Ther. 207:705-718 (1978).
15. Pintor, J., B. F. King, M. T. Miras-Portugal, and G. Burnstock. Selectivity of adenine dinucleotides at recombinant P2X2 and P2Y1 purinoceptors. Br. J. Pharmacol. 119:1006-1012 (1996)
16. 4A binding sites in rat brain. Neuroscience, in press.
17. 4A and ADP-β-S binding to P2-purinoceptors present on rat brain synaptic terminals. Br. J. Pharmacol. 108:1094-1099 (1993).
18. 4A, ATP and α,β-methylene ATP in guinea pig urinary bladder. Br. J. Pharmacol. 117:698-702 (1996).
19. 2x-purinoceptors and for purinergic transmission. Eur. J. Pharmacol. 174:115-118 (1989).
20. 5A and α,β-methylene ATP on non-adrenergic, non-cholinergic neurogenic excitation in the guinea pig vas deferens. Br. J. Pharmacol. 94:699-706 (1988).
21. 2+ channels in rat central neurones. Neuroscience 70:353-360 (1995).
22. Hoyle, C. H. V. Pharmacological activity of adenine dinucleotides in the periphery: possible receptor classes and transmitter functions. Gen. Pharmacol. 21:827-831 (1990).
23. 2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol. 115:1619-1627 (1995).
24. Hilderman, R. H., M. Martim, J. K. Zimmerman, and E. B. Pivorun. Identification of a unique membrane receptor for adenosine 5′,5‴-p1,p4-tetraphosphate. J. Biol. Chem. 266:6915-6918 (1991).
25. Walker, J., T. E. Lewis, E. B. Pivorun, and R. H. Hilderman. Activation of the mouse heart adenosine 5′,5‴-P1-P4-tetraphosphate receptor. Biochemistry 32:1264-1269 (1993).
26. Hoyle, C. H. V., A. U. Ziganshin, J. Pintor, and G. Burnstock. The activation of P1-and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates. Br. J. Pharmacol. 118:1294-1300 (1996).
27. Ramos A., J. Pintor, M. T. Miras-Portugal, and P. Rotllán. Use of fluorogenic substrates for detection and investigation of ectoenzymatic hydrolysis of diadenosine polyphosphates: a fluorometric study on chromaffin cells. Anal. Biochem. 228:74-82 (1995).
28. Mateo J., P. Rotllán, and M. T. Miras-Portugal. Suramin: a powerful inhibitor of neural ecto-diadenosine polyphosphate hydrolase. Br. J. Pharmacol. 119:1-2 (1996).