Modulation of the dinucleotide receptor present in rat midbrain synaptosomes by adenosine and ATP

British Journal of Pharmacology

Volumn 130, Issue 2, 2000, Pages 434-440

  Díaz Hernández, Miguel ^a   Pintor, Jesús ^a   Miras Portugal, M Teresa ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Adenosine; Adenosine receptor; Alkaline phosphatase; ATP; Diadenosine polyphosphates; Dinucleotide receptor

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; CYCLOHEXYLADENOSINE; DIADENOSINE PENTAPHOSPHATE; DINUCLEOTIDE; PRESYNAPTIC RECEPTOR; PURINE P2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM CURRENT; CONTROLLED STUDY; DOSE RESPONSE; MALE; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

EID: 0034061872     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703300     Document Type: Article

References (29)

1. BARRIE, A.P. & NICHOLLS, D.G. (1993). Adenosine Al receptors inhibition of glutamate exoeytosis and protein kinase C-mediayted decoupling. J. Neurochem., 60, 1081-1086.
2. BAXI, M.D. & VISHWANATHA, J.K. (1995). Diadenosine polyphosphates: their biological significance. J. Pharmacol. Toxicol. Methods, 33, 121-128.
3. FASTBOM, J. & FREDHOLM, B.B. (1990). Effects of long-term theophylline treatment on adenosine Al-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins. Brain Res., 507, 195-199.
4. 1 receptors in rat brain. Am. J. Physiol., 36, C1651-C1656.
5. FREDHOLM, B.B., ABBRACCIO, M.P., BURNSTOCK, G., DALY, J.W., HARDEN, T.K., JACOBSON, K., LEFF, P. & WILLIAMS, M. (1994). Nomenclature and classification of purinoceptors. Pharmacol. Rev., 16, 143-156.
6. FRÖHLICH, R., BOEHMET, S. & ILLES, P. (1996). Pharmacological characterization of P2 purinoceptors types in rat locus coeruleus neurons. Eur. J. Pharmacol., 315, 255-261.
7. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
8. GUALIX, J., FIDEU, M.D., PINTOR, J., ROTLLÁN, P., GARCÍA-CARMONA, F. & MIRAS-PORTUGAL, M.T. (1997). Characterization of diadenosine polyphosphate transport into chromaffin granules from adrenal medulla. FASEB J., 11, 981-990.
9. HAMANN, M. & ATTWELL, D. (1996). Non-synaptic release of ATP by electrical stimulation in slices of rat hippocampus, cerebellum and habenula. Eur. J. Neurosci., 8, 1510-1515.
10. c but not in cAMP mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway. Eur. J. Neurosci., 8, 700-709.
11. HOYLE, C.H.V. (1990). Pharmacological activity of adenine dinucleotides in the periphery: possible receptor classes and transmitter functions. Gen. Pharmacol., 21, 827-831.
12. KLISHIN, A., LOZOVAYA, N., PINTOR, J., MIRAS-PORTUGAL, M.T. & KRISHTAL, O. (1994). Possible functional role of diadenosine polyphosphates: negative feedback for excitation in hippocampus. Neuroscience, 58, 235-236.
13. 1 adenosine receptors. FASEB J., 5, 2668-2676.
14. MATED, J., ROTLLÁN, P. & MIRAS-PORTUGAL, M.T. (1996). Suramin - a powerful inhibitor of neural ecto-diadenosine polyphosphate hydrolase. Br. J. Pharmacol., 119, 1-2.
15. 4A and other Dinucleoside Plyphosphates. ed. McLennan, A.G. Boca Raton, FL, U.S.A.: CRC Press.
16. 2+ dependent release evoked by 4-aminopyridine and veratridine. Neurosci. Lett., 136, 141-144.
17. PINTOR, J., GUALIX, J. & MIRAS-PORTUGAL, M.T. (1997a). Dinucleotide receptor modulation by protein kinase (PKA and PKC) and protein phosphatases in rat brain synaptic terminals. J. Neurochem., 68, 2552-2557.
18. 2 purinergic receptors for diadenosine polyphosphates in the nervous system. Gen. Pharmacol., 26, 229-235.
19. PINTOR, J. & MIRAS-PORTUGAL, M.T. (1995b). A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat brain synaptosomes. Br. J. Pharmacol., 115, 895-902.
20. 2+ transients in guinea-pig brain via receptors distinct from those for ATP. J. Physiol., 504, 327-335.
21. 2+ influx distinct from ATP mediated influx. J. Neurosci. Res., 44, 478-489.
22. POTTER, P.E. & WHITE, T.W. (1980). Release of adenine 5′triphosphate from synaptosomes from differents areas of the brain. Neurosci., 5, 1351-1356.
23. RIBEIRO, J.A. (1995). Purinergic inhibition of neurotransmitter release in the central nervous system. Pharmacol. Toxical., 77, 299-305.
24. SCHUBERT, P., PINTOR, J. & MIRAS-PORTUGAL, M.T. (1995). Inhibitory action of adenosine and adenine dinucleotides on synaptic transmission in the central nervous system. In Adenosine and adenine nucleotides: from molecular biology to integrative physiology. ed. Belardeinelli, L. & Pelleg Kluwer, A. pp. 281-288. Boston: Academic Publishers.
25. STONE, T.W. & PERKINS, M.N. (1981). Adenine dinucleotide effect on rat cortical neurones. Brain Res., 229, 241-245.
26. WU, L.G. & SAGGAU, P. (1994). Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus. Neuron. 12, 1139-1148.
27. 2+ channels by adenosine autoreceptors. Nature, 365, 256-258.
28. ZIGANSHIN, A.U., HOYLE, C.H.V., BO, X., LAMBRECH, G., MUTSCHER, E., BAUMERT, H.G. & BURNSTOCK, G. (1993). PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110, 1491-1495.
29. ZIMMERMANN, H. (1996). Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog. Neurobiol., 49, 589-618.