Influences of α-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Brazilian Journal of Medical and Biological Research

Volumn 34, Issue 12, 2001, Pages 1539-1545

  Peluzio, M C G ^a   Homem, A P P ^a   Cesar, G C ^a   Azevedo, G S ^a   Amorim, R ^a   Cara, D C ^a   Saliba, H ^a   Vieira, E C ^a   Arantes, R E ^a   Alvarez Leite, J ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Antioxidants; Apo E; Atherosclerosis; Cholesterol; Mice; tocopherol

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN E; BILE ACID; CHOLESTEROL; LIPOPROTEIN; STEROL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA DISEASE; ARTICLE; ATHEROGENESIS; ATHEROGENIC DIET; ATHEROSCLEROSIS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FECES LEVEL; FOOD INTAKE; HISTOPATHOLOGY; HYPERLIPOPROTEINEMIA TYPE 3; MOUSE; NONHUMAN; VITAMIN SUPPLEMENTATION;

ANIMALIA;

EID: 0035746067     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2001001200005     Document Type: Article

References (36)

1. Antioxidant protection of low density lipoprotein and its role in the prevention of atherosclerotic vascular disease
2. Atherosclerosis, oxidative stress and antioxidant protection in endothelium-derived relaxing factor action
3. Hipótese oxidative da aterosclerose e emprego dos antioxidantes na doençsa arterial coronária
4. Prevention of atherosclerosis with dietary antioxidants: Fact or fiction?
5. Dietary influences on membrane function: Importance in protection against oxidative damage and disease
6. Effect of oral supplementation with D-α-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation
7. Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse
8. β-Carotene and α-tocopherol inhibit the development of atherosclerotic lesions in hypercholesterolemic rabbits
9. Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits
10. Effect of vitamin E on atherogenesis in LDL receptor-deficient rabbits
11. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
12. Generation of mice carrying a mutant apolipoprotein gene inactivated by gene targeting in embryonic stem cells
13. Determination of vitamin E in biological specimens and foods by HPLC-pretreatment of samples and extraction of tocopherols
14. Enzymatic determination of total serum cholesterol
15. t-Butanol extraction of feces: A rapid procedure for enzymic determination of fecal bile acids
16. Direct spectrophotometry of total bile acids in serum
17. A simple method for the isolation and purification of total lipids from animal tissues
18. Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol
19. Vitamin E: Beyond antioxidant function
20. Vitamin E requirements, transport and metabolism: Role of α-tocopherol-binding proteins
21. Absorption, lipoprotein transport and regulation of plasma concentrations of vitamin E in humans
22. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in Apo E-deficient mice
23. Hypocholesterolemic effect of vitamin E on cholesterol-fed rabbit
24. Dietary antioxidants do not reduce fatty streak formation in the C57BL/6 mouse atherosclerosis model
25. Dietary β-carotene and α-tocopherol combination does not inhibit atherogenesis in an Apo E-deficient mouse model
26. Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits
27. The unexpected role of vitamin E (α-tocopherol) in the peroxidation of human low density lipoprotein
28. -/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis
29. Coantioxidants make α-tocopherol an efficient antioxidant for low density lipoprotein
30. The effect of tocopherol on high-density lipoprotein cholesterol
31. Effect of vitamin E on lipids
32. Vitamin E does not modify HDL-cholesterol
33. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
34. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
35. Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis
36. Increased plasma and lipoprotein lipid peroxidation in Apo-E deficient mice