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Volumn 32, Issue 1, 1999, Pages 27-34

The unexpected role of vitamin E (α-tocopherol) in the peroxidation of human low-density lipoprotein

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; LOW DENSITY LIPOPROTEIN;

EID: 0032955098     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar950059o     Document Type: Article
Times cited : (203)

References (79)
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    • Some reported correlations between α-TOH content and resistance of LDL to peroxidation: (Positive) Esterbauer, H.; Dieber Rotheneder, M.; Striegl, G.; Waeg, G. Am. J. Clin. Nutr. 1991, 53, 314s-321s. (Erratic or minor) McDowell, I. F. W.; Brennan, G. M.; McEneny, J.; Young, I. S.; Nicholls, D. P.; McVeigh, G. E.; Bruce, I.; Trimble, E. R.; Johnston, G. D. Eur. J. Clin. Invest. 1994, 24, 759-765. (Negative) Iwatsuki, M.; Niki, E.; Stone, D.; Darley-Usmar, V. M. FEBS Lett. 1995, 360, 271-276. Croft, K. D.; Williams, P.; Dimmitt, S.; Abu Amsha, R.; Beilin, L. J. Biochim. Biophys. Acta 1995, 1254, 250-256.
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    • Some reported correlations between α-TOH content and resistance of LDL to peroxidation: (Positive) Esterbauer, H.; Dieber Rotheneder, M.; Striegl, G.; Waeg, G. Am. J. Clin. Nutr. 1991, 53, 314s-321s. (Erratic or minor) McDowell, I. F. W.; Brennan, G. M.; McEneny, J.; Young, I. S.; Nicholls, D. P.; McVeigh, G. E.; Bruce, I.; Trimble, E. R.; Johnston, G. D. Eur. J. Clin. Invest. 1994, 24, 759-765. (Negative) Iwatsuki, M.; Niki, E.; Stone, D.; Darley-Usmar, V. M. FEBS Lett. 1995, 360, 271-276. Croft, K. D.; Williams, P.; Dimmitt, S.; Abu Amsha, R.; Beilin, L. J. Biochim. Biophys. Acta 1995, 1254, 250-256.
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    • Some reported correlations between α-TOH content and resistance of LDL to peroxidation: (Positive) Esterbauer, H.; Dieber Rotheneder, M.; Striegl, G.; Waeg, G. Am. J. Clin. Nutr. 1991, 53, 314s-321s. (Erratic or minor) McDowell, I. F. W.; Brennan, G. M.; McEneny, J.; Young, I. S.; Nicholls, D. P.; McVeigh, G. E.; Bruce, I.; Trimble, E. R.; Johnston, G. D. Eur. J. Clin. Invest. 1994, 24, 759-765. (Negative) Iwatsuki, M.; Niki, E.; Stone, D.; Darley-Usmar, V. M. FEBS Lett. 1995, 360, 271-276. Croft, K. D.; Williams, P.; Dimmitt, S.; Abu Amsha, R.; Beilin, L. J. Biochim. Biophys. Acta 1995, 1254, 250-256.
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    • Where LH refers to a bisallylic group in a polyunsaturated fatty acid ester (phospholipid, triglyceride, cholesterol ester, etc.), L• and LOO• are the derived carbon-centered radical and lipid peroxyl radical, respectively, and ROO• is the peroxyl radical which initiates lipid peroxidation.
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    • note
    • p = 170 (inhibition) vs 3800 (peroxyl clock).
  • 40
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    • 8 (LOO• + α-TO•).
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    • 2 into ubiquinone-10 (CoQ).
  • 50
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    • That is, not until over 85% of the original α-TOH had been consumed, at which point many of the particles would be left unprotected.
  • 53
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    • 41 and that of α-TO• may be even longer because it lacks the hydrophilic OH group.
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    • note
    • With the simplest case assumption that particles are uniformly likely to react with the initiating ROO•.
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    • polymer'/monomer.
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    • intraparticle = 1 molecule/particle volume ≈ 0.5 mM.
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    • Reference 26 gives a more exact analysis.
  • 62
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    • note
    • 0.5 relationship has been confirmed for some compounds.
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    • note
    • 2O-washed reaction mixture and vice versa.
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    • 2O-LDL, presumably because of the lower phasetransfer activity of α-TOD.
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    • See: Yoshida, Y.; Tsuchiya, J.; Niki, E. Biochim. Biophys. Acta 1994, 1200, 85-92. Lynch, S. M.; Frei, B. J. Biol. Chem. 1995, 270, 5158-5163. Kontush, A.; Meyer, S.; Finckh, B.; Kohlschutter, A.; Beisiegel, U. J. Biol. Chem. 1996, 271, 11106-11112.
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    • See: Yoshida, Y.; Tsuchiya, J.; Niki, E. Biochim. Biophys. Acta 1994, 1200, 85-92. Lynch, S. M.; Frei, B. J. Biol. Chem. 1995, 270, 5158-5163. Kontush, A.; Meyer, S.; Finckh, B.; Kohlschutter, A.; Beisiegel, U. J. Biol. Chem. 1996, 271, 11106-11112.
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    • 2 = 0.043 (Figure 14 in ref 6).
  • 74
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    • note
    • p being independent of the initiation rate.
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