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Volumn 137, Issue 1, 1998, Pages 1-11

Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis

Author keywords

APOE; Apolipoprotein; Cholesterol; Gene targeting; Lipoprotein; Triglyceride

Indexed keywords

APOLIPOPROTEIN C1; APOLIPOPROTEIN E; VERY LOW DENSITY LIPOPROTEIN;

EID: 0032478347     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)00266-9     Document Type: Review
Times cited : (83)

References (83)
  • 1
    • 0023897329 scopus 로고
    • Genetic factors affecting blood lipoproteins: The candidate gene approach
    • Lusis A.J. Genetic factors affecting blood lipoproteins: the candidate gene approach. J Lipid Res. 29:1988;397-429.
    • (1988) J Lipid Res , vol.29 , pp. 397-429
    • Lusis, A.J.1
  • 2
    • 0016913871 scopus 로고
    • Inbred mice and their hypbrids as an animal model for atherosclerosis research
    • Roberts A., Thompson J.S. Inbred mice and their hypbrids as an animal model for atherosclerosis research. Adv Exp Med Biol. 67:1976;313-327.
    • (1976) Adv Exp Med Biol , vol.67 , pp. 313-327
    • Roberts, A.1    Thompson, J.S.2
  • 3
    • 0025322603 scopus 로고
    • Synthetic low and high fat diets for the study of atherosclerosis in the mouse
    • Nishina P.M., Verstuyft J., Paigen B. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res. 31:1990;859-869.
    • (1990) J Lipid Res , vol.31 , pp. 859-869
    • Nishina, P.M.1    Verstuyft, J.2    Paigen, B.3
  • 4
    • 0029970057 scopus 로고    scopus 로고
    • Apolipoprotein E as a risk factor for coronary heart disease: A genetic and molecular biology approach
    • De Knijff P., Havekes L.M. Apolipoprotein E as a risk factor for coronary heart disease: a genetic and molecular biology approach. Curr Opin Lipid. 7:1996;59-63.
    • (1996) Curr Opin Lipid , vol.7 , pp. 59-63
    • De Knijff, P.1    Havekes, L.M.2
  • 5
    • 0024820009 scopus 로고
    • Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127
    • Wardell M.R., Weisgraber K.H., Havekes L.M., Rall S.C. Jr. Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127. J Biol Chem. 264:1989;21205-21210.
    • (1989) J Biol Chem , vol.264 , pp. 21205-21210
    • Wardell, M.R.1    Weisgraber, K.H.2    Havekes, L.M.3    Rall S.C., Jr.4
  • 7
    • 0019820184 scopus 로고
    • Type III hyperlipoproteinemia associated with apolipoprotein E deficiency
    • Ghiselli G., Schaefer E.J., Gascon P., Breser H.B. Jr. Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. Science. 214(4526):1981;1239-1241.
    • (1981) Science , vol.214 , Issue.4526 , pp. 1239-1241
    • Ghiselli, G.1    Schaefer, E.J.2    Gascon, P.3    Breser H.B., Jr.4
  • 8
    • 0344310727 scopus 로고
    • Evolution of apolipoprotein E: Mouse sequence and evidence for an 11-nucleotide ancestral unit
    • Rajavashisth T.B., Kaptein J.S., Reue K.L., Lusis A.J. Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit. Proc Natl Acad Sci USA. 82:1985;8085-8089.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8085-8089
    • Rajavashisth, T.B.1    Kaptein, J.S.2    Reue, K.L.3    Lusis, A.J.4
  • 9
    • 0027462882 scopus 로고
    • Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: Structure and genetic variablity in inbred mice
    • Hoffer M.J.V., Hofker M.H., Van Eck M.M., Havekes L.M., Frants R.R. Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: Structure and genetic variablity in inbred mice. Genomics. 15:1993;62-67.
    • (1993) Genomics , vol.15 , pp. 62-67
    • Hoffer, M.J.V.1    Hofker, M.H.2    Van Eck, M.M.3    Havekes, L.M.4    Frants, R.R.5
  • 10
    • 0028201048 scopus 로고
    • The apolipoprotein C2-linked (Acl) gene: A new gene within the mouse apolipoprotein e-c1-c2 gene cluster
    • Van Eck M.M., Hoffer M.J.V., Havekes L.M., Frants R.R., Hofker M.H. The apolipoprotein C2-linked (Acl) gene: A new gene within the mouse apolipoprotein e-c1-c2 gene cluster. Genomics. 21:1994;110-115.
    • (1994) Genomics , vol.21 , pp. 110-115
    • Van Eck, M.M.1    Hoffer, M.J.V.2    Havekes, L.M.3    Frants, R.R.4    Hofker, M.H.5
  • 11
    • 0029162877 scopus 로고
    • Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus
    • Allan C.M., Walker D., Segrest J.P., Taylor J.M. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. Genomics. 28:1995;291-300.
    • (1995) Genomics , vol.28 , pp. 291-300
    • Allan, C.M.1    Walker, D.2    Segrest, J.P.3    Taylor, J.M.4
  • 12
    • 0023943675 scopus 로고
    • The apolipoprotein multigene family: Biosynthesis, structure-function relationships, and evolution
    • Li W.-H., Tanimura M., Luo C.-C., Datta S., Chan L. The apolipoprotein multigene family: biosynthesis, structure-function relationships, and evolution. J Lipid Res. 29:1988;245-271.
    • (1988) J Lipid Res , vol.29 , pp. 245-271
    • Li, W.-H.1    Tanimura, M.2    Luo, C.-C.3    Datta, S.4    Chan, L.5
  • 13
    • 0028069690 scopus 로고
    • Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E
    • De Silva H.V., Lauer S.J., Wang J., Simonet W.S., Weisgraber K.H., Mahley R.W., Taylor J.M. Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. J Biol Chem. 269:1994;2324-2335.
    • (1994) J Biol Chem , vol.269 , pp. 2324-2335
    • De Silva, H.V.1    Lauer, S.J.2    Wang, J.3    Simonet, W.S.4    Weisgraber, K.H.5    Mahley, R.W.6    Taylor, J.M.7
  • 14
    • 0025030698 scopus 로고
    • Hypertriglyceridemia as a result of human apoCIII gene expression in transgenic mice
    • Ito Y., Azrolan N., O'Connell A., Walsh A., Breslow J.L. Hypertriglyceridemia as a result of human apoCIII gene expression in transgenic mice. Science. 249:1990;790-793.
    • (1990) Science , vol.249 , pp. 790-793
    • Ito, Y.1    Azrolan, N.2    O'Connell, A.3    Walsh, A.4    Breslow, J.L.5
  • 16
    • 0029851509 scopus 로고    scopus 로고
    • In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway
    • Jong M.C., Dahlmans V.E.H., Van Gorp P.J.J., Willems van Dijk K., Breuer M.L., Hofker M.H., Havekes L.M. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. J Clin Invest. 98(10):1996;2259-2267.
    • (1996) J Clin Invest , vol.98 , Issue.10 , pp. 2259-2267
    • Jong, M.C.1    Dahlmans, V.E.H.2    Van Gorp, P.J.J.3    Willems Van Dijk, K.4    Breuer, M.L.5    Hofker, M.H.6    Havekes, L.M.7
  • 17
    • 0029891752 scopus 로고    scopus 로고
    • Expression of a novel human apolipoprotein (apoc IV) causes hypertriglyceridemia in transgenic mice
    • Allan C.M., Taylor J.M. Expression of a novel human apolipoprotein (apoc IV) causes hypertriglyceridemia in transgenic mice. J Lipid Res. 37(7):1996;1510-1518.
    • (1996) J Lipid Res , vol.37 , Issue.7 , pp. 1510-1518
    • Allan, C.M.1    Taylor, J.M.2
  • 18
    • 0026536066 scopus 로고
    • Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
    • Piedrahita J.A., Zhang S.H., Hagaman J.R., Oliver P.M., Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA. 89:1992;4471-4475.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4471-4475
    • Piedrahita, J.A.1    Zhang, S.H.2    Hagaman, J.R.3    Oliver, P.M.4    Maeda, N.5
  • 19
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump A.S., Smith J.D., Hayek T., Aalto-Setälä K., Walsh A., Rubin E.M., Breslow J. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 71:1992;343-353.
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setälä, K.4    Walsh, A.5    Rubin, E.M.6    Breslow, J.7
  • 21
    • 0028146233 scopus 로고
    • Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
    • Zhang S.H., Reddick R.L., Burkey B., Maeda N. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest. 94:1994;937-945.
    • (1994) J Clin Invest , vol.94 , pp. 937-945
    • Zhang, S.H.1    Reddick, R.L.2    Burkey, B.3    Maeda, N.4
  • 22
    • 0023103188 scopus 로고
    • Comparison of atherosclerotic lesions and HDL-lipid levels in male, female and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H
    • Paigen B., Holmes P., Mitchel D., Albee D. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis. 64:1987;215-221.
    • (1987) Atherosclerosis , vol.64 , pp. 215-221
    • Paigen, B.1    Holmes, P.2    Mitchel, D.3    Albee, D.4
  • 23
    • 15844414655 scopus 로고    scopus 로고
    • Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo
    • Rensen P.C.N., Van Berkel T.J.C. Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo. J Biol Chem. 271(25):1996;14791-14799.
    • (1996) J Biol Chem , vol.271 , Issue.25 , pp. 14791-14799
    • Rensen, P.C.N.1    Van Berkel, T.J.C.2
  • 24
    • 0025296378 scopus 로고
    • In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice
    • Simonet W.S., Bucay N., Lauer S.J., Wirak D.O., Stevens M.E., Weisgraber K.H., Pitas R.E., Taylor J.M. In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice. J Biol Chem. 265:1990;10809-10812.
    • (1990) J Biol Chem , vol.265 , pp. 10809-10812
    • Simonet, W.S.1    Bucay, N.2    Lauer, S.J.3    Wirak, D.O.4    Stevens, M.E.5    Weisgraber, K.H.6    Pitas, R.E.7    Taylor, J.M.8
  • 25
    • 0025158228 scopus 로고
    • Accumulation of human apolipoprotein E in the plasma of transgenic mice
    • Smith J.D., Plump A.S., Hayek T., Walsh A., Breslow J.L. Accumulation of human apolipoprotein E in the plasma of transgenic mice. J Biol Chem. 265:1990;14709-14712.
    • (1990) J Biol Chem , vol.265 , pp. 14709-14712
    • Smith, J.D.1    Plump, A.S.2    Hayek, T.3    Walsh, A.4    Breslow, J.L.5
  • 26
    • 0025912304 scopus 로고
    • Multiple tissue specific elements control the apolipoprotein E/CI Gene locus in transgenic mice
    • Simonet W.S., Bucay N., Pitas R.E., Lauer S.J., Taylor J.M. Multiple tissue specific elements control the apolipoprotein E/CI Gene locus in transgenic mice. J Biol Chem. 266:1991;8651-8654.
    • (1991) J Biol Chem , vol.266 , pp. 8651-8654
    • Simonet, W.S.1    Bucay, N.2    Pitas, R.E.3    Lauer, S.J.4    Taylor, J.M.5
  • 27
    • 0027369115 scopus 로고
    • Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus
    • Shachter N.S., Zhu Y., Walsh A., Breslow J.L., Smith J.D. Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus. J Lipid Res. 34:1993;1699-1707.
    • (1993) J Lipid Res , vol.34 , pp. 1699-1707
    • Shachter, N.S.1    Zhu, Y.2    Walsh, A.3    Breslow, J.L.4    Smith, J.D.5
  • 28
    • 0027471464 scopus 로고
    • A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice
    • Simonet W.S., Bucay N., Lauer S.J., Taylor J.M. A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. J Biol Chem. 268:1993;8221-8229.
    • (1993) J Biol Chem , vol.268 , pp. 8221-8229
    • Simonet, W.S.1    Bucay, N.2    Lauer, S.J.3    Taylor, J.M.4
  • 29
    • 0028825717 scopus 로고
    • Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus - Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice
    • Allan C.M., Walker D., Taylor J.M. Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus - Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice. J Biol Chem. 270:1995;26278-26281.
    • (1995) J Biol Chem , vol.270 , pp. 26278-26281
    • Allan, C.M.1    Walker, D.2    Taylor, J.M.3
  • 30
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
    • Gu H., Zou Y.R., Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 73(6):1993;1155-1164.
    • (1993) Cell , vol.73 , Issue.6 , pp. 1155-1164
    • Gu, H.1    Zou, Y.R.2    Rajewsky, K.3
  • 32
    • 0024559621 scopus 로고
    • Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3; Structure and genetics of an apolipoprotein E variant
    • Rall S.C. Jr., Newhouse Y.M., Clarke H.R.G., Weisgraber K.H., McCarthy B.J., Mahley R.W., Bersot T.P. Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3; structure and genetics of an apolipoprotein E variant. J Clin Invest. 83:1989;1095-1101.
    • (1989) J Clin Invest , vol.83 , pp. 1095-1101
    • Rall S.C., Jr.1    Newhouse, Y.M.2    Clarke, H.R.G.3    Weisgraber, K.H.4    McCarthy, B.J.5    Mahley, R.W.6    Bersot, T.P.7
  • 34
    • 0029852240 scopus 로고    scopus 로고
    • In the absence of endogenous mous apolipoprotein E, apolipoprotein E2(Arg-158→Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E3leiden transgenic mice
    • Van Vlijmen B.J.M., Willems van Dijk K., Van't Hof H.B., Van Gorp P.J.J., Van der Zee A., Van der Boom H., Breuer M.L., Hofker M.H., Havekes L.M. In the absence of endogenous mous apolipoprotein E, apolipoprotein E2(Arg-158→Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E3leiden transgenic mice. J Biol Chem. 271(48):1996;30595-30602.
    • (1996) J Biol Chem , vol.271 , Issue.48 , pp. 30595-30602
    • Van Vlijmen, B.J.M.1    Willems Van Dijk, K.2    Van'T Hof, H.B.3    Van Gorp, P.J.J.4    Van Der Zee, A.5    Van Der Boom, H.6    Breuer, M.L.7    Hofker, M.H.8    Havekes, L.M.9
  • 36
    • 0027216450 scopus 로고
    • Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
    • Fazio S., Lee Y.-L., Ji Z.-S., Rall S.C. Jr. Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E. J Clin Invest. 92:1993;1497-1503.
    • (1993) J Clin Invest , vol.92 , pp. 1497-1503
    • Fazio, S.1    Lee, Y.-L.2    Ji, Z.-S.3    Rall S.C., Jr.4
  • 37
    • 0028314348 scopus 로고
    • Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant
    • Fazio S., Horie Y., Simonet W.S., Weisgraber K.H., Taylor J.M., Rall S.C. Jr. Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant. J Lipid Res. 35:1994;408-416.
    • (1994) J Lipid Res , vol.35 , pp. 408-416
    • Fazio, S.1    Horie, Y.2    Simonet, W.S.3    Weisgraber, K.H.4    Taylor, J.M.5    Rall S.C., Jr.6
  • 38
    • 0029828908 scopus 로고    scopus 로고
    • Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2
    • Huang Y., Schwendner S.W., Rall S.C. Jr., Mahley R.W. Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J Biol Chem. 271(46):1997;29146-29151.
    • (1997) J Biol Chem , vol.271 , Issue.46 , pp. 29146-29151
    • Huang, Y.1    Schwendner, S.W.2    Rall S.C., Jr.3    Mahley, R.W.4
  • 39
    • 0028284556 scopus 로고
    • Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
    • Willnow T.E., Sheng Z., Ishibashi S., Herz J. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 264(5164):1994;1471-1474.
    • (1994) Science , vol.264 , Issue.5164 , pp. 1471-1474
    • Willnow, T.E.1    Sheng, Z.2    Ishibashi, S.3    Herz, J.4
  • 41
    • 0026531139 scopus 로고
    • Overexpression of apolipoprotein E in transgenic mice: Marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia
    • Shimano H., Yamada N., Katsuki M., Shimada M., Gotoda T., Harada K., Murase T., Fukazawa C., Takaku F., Yazaki Y. Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. Proc Natl Acad Sci USA. 89:1992;1750-1754.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1750-1754
    • Shimano, H.1    Yamada, N.2    Katsuki, M.3    Shimada, M.4    Gotoda, T.5    Harada, K.6    Murase, T.7    Fukazawa, C.8    Takaku, F.9    Yazaki, Y.10
  • 42
    • 0026458283 scopus 로고
    • Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E; Accelerated clearance of lipoproteins containing apoB
    • Shimano H., Yamada N., Katsuki M., Yamamoto K., Gotoda T., Harada K., Shimada M., Yazaki Y. Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E; accelerated clearance of lipoproteins containing apoB. J Clin Invest. 90:1992;2084-2091.
    • (1992) J Clin Invest , vol.90 , pp. 2084-2091
    • Shimano, H.1    Yamada, N.2    Katsuki, M.3    Yamamoto, K.4    Gotoda, T.5    Harada, K.6    Shimada, M.7    Yazaki, Y.8
  • 43
    • 0025302165 scopus 로고
    • Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
    • Kowal R.C., Herz J., Weisgraber K.H., Mahley R.W., Brown M.S., Goldstein J.L. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem. 263:1990;10771-10779.
    • (1990) J Biol Chem , vol.263 , pp. 10771-10779
    • Kowal, R.C.1    Herz, J.2    Weisgraber, K.H.3    Mahley, R.W.4    Brown, M.S.5    Goldstein, J.L.6
  • 46
    • 13344269692 scopus 로고    scopus 로고
    • Modulation of very low density lipoprotein production and clearance contributes to age- and gender-dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice
    • Van Vlijmen B.J.M., Van't Hof H.B., Mol M.J.T.M., Van der Boom H., Van der Zee A., Frants R.R., Hofker M.H., Havekes L.M. Modulation of very low density lipoprotein production and clearance contributes to age- and gender-dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice. J Clin Invest. 97:1996;1184-1192.
    • (1996) J Clin Invest , vol.97 , pp. 1184-1192
    • Van Vlijmen, B.J.M.1    Van'T Hof, H.B.2    Mol, M.J.T.M.3    Van Der Boom, H.4    Van Der Zee, A.5    Frants, R.R.6    Hofker, M.H.7    Havekes, L.M.8
  • 48
    • 0027958084 scopus 로고
    • ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    • Nakashima Y., Plump A.S., Raines E.W., Breslow J.L., Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 14:1994;133-140.
    • (1994) Arterioscler Thromb , vol.14 , pp. 133-140
    • Nakashima, Y.1    Plump, A.S.2    Raines, E.W.3    Breslow, J.L.4    Ross, R.5
  • 49
    • 0027976942 scopus 로고
    • Atherosclerosis in mice lacking apoE: Evaluation of lesional development and progression
    • Reddick R.L., Zhang S.H., Maeda N. Atherosclerosis in mice lacking apoE: Evaluation of lesional development and progression. Arterioscler Thromb. 14:1994;141-147.
    • (1994) Arterioscler Thromb , vol.14 , pp. 141-147
    • Reddick, R.L.1    Zhang, S.H.2    Maeda, N.3
  • 50
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang S.H., Reddick R.L., Piedrahita J.A., Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 258:1992;468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 51
    • 0028862192 scopus 로고
    • Quantitation of atherosclerosis in murine models: Correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
    • Tangirala R.K., Rubin E.M., Palinski W. Quantitation of atherosclerosis in murine models: Correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res. 36:1995;2320-2328.
    • (1995) J Lipid Res , vol.36 , pp. 2320-2328
    • Tangirala, R.K.1    Rubin, E.M.2    Palinski, W.3
  • 53
    • 0028105142 scopus 로고
    • Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142)
    • Fazio S., Sanan D.A., Lee Y.-L., Ji Z.-S., Mahley R.W., Rall S.C. Jr. Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142). Arterioscler Thromb. 14:1994;1873-1879.
    • (1994) Arterioscler Thromb , vol.14 , pp. 1873-1879
    • Fazio, S.1    Sanan, D.A.2    Lee, Y.-L.3    Ji, Z.-S.4    Mahley, R.W.5    Rall S.C., Jr.6
  • 55
    • 0028125108 scopus 로고
    • Effect of human ApoE4 on the clearance of chylomicron-like lipid emulsions and atherogenesis in transgenic mice
    • Mortimer B.-C., Redgrave T.G., Spangler E.A., Verstuyft J.G., Rubin E.M. Effect of human ApoE4 on the clearance of chylomicron-like lipid emulsions and atherogenesis in transgenic mice. Arterioscler Thromb. 14:1994;1542-1552.
    • (1994) Arterioscler Thromb , vol.14 , pp. 1542-1552
    • Mortimer, B.-C.1    Redgrave, T.G.2    Spangler, E.A.3    Verstuyft, J.G.4    Rubin, E.M.5
  • 56
    • 0028198105 scopus 로고
    • ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis: Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum
    • Palinski W., Ord V.A., Plump A.S., Breslow J.L., Steinberg D., Witztum J.L. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis: Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb. 14:1994;605-616.
    • (1994) Arterioscler Thromb , vol.14 , pp. 605-616
    • Palinski, W.1    Ord, V.A.2    Plump, A.S.3    Breslow, J.L.4    Steinberg, D.5    Witztum, J.L.6
  • 57
    • 0029097852 scopus 로고
    • Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis
    • Palinski W., Tangirala R.K., Miller E., Young S.G., Witztum J.L. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis. Arterioscler Thromb Vasc Biol. 15:1995;1569-1576.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1569-1576
    • Palinski, W.1    Tangirala, R.K.2    Miller, E.3    Young, S.G.4    Witztum, J.L.5
  • 58
    • 0344382051 scopus 로고    scopus 로고
    • Characterization of atherosclerotic lesions in apoE3Leiden transgenic mice: Expression of scavenger receptors and low density lipoprotein receptor-related protein and the presence of oxidized low density lipoproteins in early and advanced atherosclerotic lesions
    • Leppanen P, Luoma J, Hofker MH, Havekes LM, Ylä-Herttuala S. Characterization of atherosclerotic lesions in apoE3Leiden transgenic mice: Expression of scavenger receptors and low density lipoprotein receptor-related protein and the presence of oxidized low density lipoproteins in early and advanced atherosclerotic lesions. Atherosclerosis 1998;136:147-52.
    • (1998) Atherosclerosis , vol.136 , pp. 147-152
    • Leppanen, P.1    Luoma, J.2    Hofker, M.H.3    Havekes, L.M.4    Ylä-Herttuala, S.5
  • 59
    • 0025177343 scopus 로고
    • Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils
    • Kodama T., Freeman M., Rohrer L., Zabrecky J., Matsudaira P., Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 343(6258):1990;531-535.
    • (1990) Nature , vol.343 , Issue.6258 , pp. 531-535
    • Kodama, T.1    Freeman, M.2    Rohrer, L.3    Zabrecky, J.4    Matsudaira, P.5    Krieger, M.6
  • 60
    • 0030934387 scopus 로고    scopus 로고
    • Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase
    • Hendriks W.L., van der Sman-de Beer F., Van Vlijmen B.J.M., Van Vark L.C., Hofker M.H., Havekes L.M. Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase. Arterioscler Thromb Vasc Biol. 17:1997;498-504.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 498-504
    • Hendriks, W.L.1    Van Der Sman-De Beer, F.2    Van Vlijmen, B.J.M.3    Van Vark, L.C.4    Hofker, M.H.5    Havekes, L.M.6
  • 61
    • 0029079926 scopus 로고
    • Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
    • Smith J.D., Trogan E., Ginsberg M., Grigaux C., Tian J., Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci USA. 92:1995;8264-8268.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8264-8268
    • Smith, J.D.1    Trogan, E.2    Ginsberg, M.3    Grigaux, C.4    Tian, J.5    Miyata, M.6
  • 63
    • 0031001972 scopus 로고    scopus 로고
    • T and B lymphocytes play a minor sole in atherosclerotic plaque formation in the apolipoprotein E deficient mouse
    • Dansky H.M., Charlton S., Harper M.M., Smith J.D. T and B lymphocytes play a minor sole in atherosclerotic plaque formation in the apolipoprotein E deficient mouse. Proc Natl Acad Sci USA. 94(9):1997;4642-4646.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.9 , pp. 4642-4646
    • Dansky, H.M.1    Charlton, S.2    Harper, M.M.3    Smith, J.D.4
  • 64
    • 0028080019 scopus 로고
    • Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet
    • Fyfe A.I., Qiao J.-H., Lusis A.J. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest. 94:1994;2516-2520.
    • (1994) J Clin Invest , vol.94 , pp. 2516-2520
    • Fyfe, A.I.1    Qiao, J.-H.2    Lusis, A.J.3
  • 65
    • 0029834032 scopus 로고    scopus 로고
    • Cholesterol efflux from macrophages and other cells
    • Von Eckardstein A. Cholesterol efflux from macrophages and other cells. Curr Opin Lipid. 7:1996;308-319.
    • (1996) Curr Opin Lipid , vol.7 , pp. 308-319
    • Von Eckardstein, A.1
  • 66
    • 0029849575 scopus 로고    scopus 로고
    • Apolipoprotein E secretion by macrophages: Its potential physiological functions
    • Mazzone T. Apolipoprotein E secretion by macrophages: its potential physiological functions. Curr Opin Lipid. 7:1996;303-307.
    • (1996) Curr Opin Lipid , vol.7 , pp. 303-307
    • Mazzone, T.1
  • 67
    • 0028883354 scopus 로고
    • Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
    • Bellosta S., Mahley R.W., Sanan D.A., Murata J., Newland D.L., Taylor J.M., Pitas R.E. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. J Clin Invest. 96:1995;2170-2179.
    • (1995) J Clin Invest , vol.96 , pp. 2170-2179
    • Bellosta, S.1    Mahley, R.W.2    Sanan, D.A.3    Murata, J.4    Newland, D.L.5    Taylor, J.M.6    Pitas, R.E.7
  • 71
    • 0028944150 scopus 로고
    • Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
    • Linton M.F., Atkinson J.B., Fazio S. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science. 267:1995;1034-1037.
    • (1995) Science , vol.267 , pp. 1034-1037
    • Linton, M.F.1    Atkinson, J.B.2    Fazio, S.3
  • 72
    • 0029081525 scopus 로고
    • Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
    • Boisvert W.A., Spangenberg J., Curtiss L.K. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation. J Clin Invest. 96:1995;1118-1124.
    • (1995) J Clin Invest , vol.96 , pp. 1118-1124
    • Boisvert, W.A.1    Spangenberg, J.2    Curtiss, L.K.3
  • 74
    • 0028935209 scopus 로고
    • Phenotypic correction of hypercholesterolemia in ApoE-deficient mice by adenovirus-mediated in vivo gene transfer
    • Stevenson S.C., Marshall-Neff J., Teng B., Lee C.B., Roy S., McClelland A. Phenotypic correction of hypercholesterolemia in ApoE-deficient mice by adenovirus-mediated in vivo gene transfer. Arterioscler Thromb. 15:1995;479-484.
    • (1995) Arterioscler Thromb , vol.15 , pp. 479-484
    • Stevenson, S.C.1    Marshall-Neff, J.2    Teng, B.3    Lee, C.B.4    Roy, S.5    McClelland, A.6
  • 77
    • 0027409026 scopus 로고
    • Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice
    • Herz J., Gerard R.D. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA. 90:1993;2812-2816.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2812-2816
    • Herz, J.1    Gerard, R.D.2
  • 78
    • 0030857810 scopus 로고    scopus 로고
    • Liver directed gene transfer and prolonged expression of three major human apoe isoforms in apoe deficient mice
    • Tsukamoto K., Smith P., Glick J.M., Rader D.J. Liver directed gene transfer and prolonged expression of three major human apoe isoforms in apoe deficient mice. J Clin Invest. 100(1):1997;107-114.
    • (1997) J Clin Invest , vol.100 , Issue.1 , pp. 107-114
    • Tsukamoto, K.1    Smith, P.2    Glick, J.M.3    Rader, D.J.4
  • 79
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet induced hypercholesterolemia and atherosclerosis
    • Sullivan P.M., Mezdour H., Aratani Y., Knouff C., Najib J., Reddick R.L., Quarfordt S.H., Maeda N. Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet induced hypercholesterolemia and atherosclerosis. J Biol Chem. 272(29):1997;17972-17980.
    • (1997) J Biol Chem , vol.272 , Issue.29 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3    Knouff, C.4    Najib, J.5    Reddick, R.L.6    Quarfordt, S.H.7    Maeda, N.8
  • 80
    • 0028167663 scopus 로고
    • Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice
    • Pászty C., Maeda N., Verstuyft J., Rubin E.M. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest. 94:1994;899-903.
    • (1994) J Clin Invest , vol.94 , pp. 899-903
    • Pászty, C.1    Maeda, N.2    Verstuyft, J.3    Rubin, E.M.4
  • 82
    • 0342855957 scopus 로고
    • Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
    • Paigen B., Mitchel D., Reue K., Morrow A., Lusis A.J., LeBoeuf R.C. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci USA. 84:1987;3763-3767.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3763-3767
    • Paigen, B.1    Mitchel, D.2    Reue, K.3    Morrow, A.4    Lusis, A.J.5    Leboeuf, R.C.6
  • 83
    • 0028788492 scopus 로고
    • Genetic factors in lipoprotein metabolism - Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach
    • Purcell-Huynh D.A., Weinreb A., Castellani L.W., Mehrabian M., Doolittle M.H., Lusis A.J. Genetic factors in lipoprotein metabolism - Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach. J Clin Invest. 96:1995;1845-1858.
    • (1995) J Clin Invest , vol.96 , pp. 1845-1858
    • Purcell-Huynh, D.A.1    Weinreb, A.2    Castellani, L.W.3    Mehrabian, M.4    Doolittle, M.H.5    Lusis, A.J.6


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