Chloroquine resistance and the pH of the malaria parasite's digestive vacuole

Drug Resistance Updates

Volumn 4, Issue 6, 2001, Pages 335-338

  Kirk, Kiaran ^a   Saliba, Kevin J ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Chloroquine resistance; Malaria; PfCRT; Pfmdr1; Pgh1; PH

Indexed keywords

ACRIDINE ORANGE; CHLOROQUINE;

ACIDITY; DIGESTIVE SYSTEM; FLUORESCENCE; HOST CELL; NONHUMAN; PH; PLASMODIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 0035744201     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2002.0234     Document Type: Editorial

References (18)

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4. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
5. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum
6. Lysosomes, pH and the anti-malarial action of chloroquine
7. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine
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9. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America
10. Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH
11. Further comments on the distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes
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13. DNA-dye fluorescence enhancement based on shifting the dimer-monomer equilibrium of fluorescent dye
14. Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine
15. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr1 gene
16. ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium
17. Intracellular CFTR: Localization and function
18. Vesicular neurotransmitter transporters: From bacteria to humans