Use of the N-in-1 approach for rapid pharmacokinetic screening of drug candidates using LC-MS-MS

American Biotechnology Laboratory

Volumn 17, Issue 10, 1999, Pages 8-10

  Liang, L ^a   Chi, C ^a   Wright, M ^a   Timby, D ^a   Unger, S ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGICAL PROCEDURES; DRUG SCREENING; MASS SPECTROMETRY; UNITED STATES;

EID: 0033277323     PISSN: 07493223     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput
2. Pharmacokinetic assessment of a mixture of compounds in the rat using simultaneous dosing and simultaneous LC/MS/MS quantitation
3. The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure
4. Rapid screening of protease inhibitors for potential oral bioavailability
5. Strategies for high throughput assays using HPLC-atmospheric pressure ionization-MS/MS in new drug discovery applications
6. Bioavailability estimates for multiple polar compounds: N-in-1 dosing and HPLC/MS/MS analysis of rat urine
7. Preclinical pharmacokinetic screening using N-in-1 dosing and LC/ISP/MS/MS analysis
8. Simultaneous MRM analysis of multiple drug mixtures in high electrolyte buffers by LC/MS/MS for cell transport studies
9. Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: Methods and application