The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori

Molecular Microbiology

Volumn 42, Issue 5, 2001, Pages 1297-1309

  Delany, Isabel ^a   Spohn, Gunther ^a   Rappuoli, Rino ^a   Scarlato, Vincenzo ^a,b  

^a CHIRON VACCINES   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; FERRITIN; FERROUS SULFATE; REGULATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GROWTH; BINDING AFFINITY; CONTROLLED STUDY; DNA FOOTPRINTING; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; HELICOBACTER PYLORI; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; REGULATORY MECHANISM; WILD TYPE;

BACTERIAL PROTEINS; BASE SEQUENCE; DEOXYRIBONUCLEASE I; DNA FOOTPRINTING; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HELICOBACTER PYLORI; HUMANS; INTRONS; IRON; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); HELICOBACTER; HELICOBACTER PYLORI;

EID: 0035724513     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02696.x     Document Type: Article

References (51)

1. Spectroscopic and saturation magnetization properties of the manganese- and cobalt-substituted Fur (ferric uptake regulation) protein from Escherichia coli
2. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
3. The ferric uptake regulation (Fur) repressor is a zinc metalloprotein
4. Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli
5. Functional analysis of the Helicobacter pylori principal sigma subunit of RNA polymerase reveals that the spacer region is important for efficient transcription
6. Cloning and characterization of the fur gene from Helicobacter pylori
7. Structural, functional and mutational analysis of the pfr gene encoding a ferritin from Helicobacter pylori
8. Regulation of ferritin-mediated cytoplasmic iron storage by the ferric uptake regulator homolog (Fur) of Helicobacter pylori
9. Helicobacter pylori infection and serum ferritin: A population-based study among 1806 adults in Germany
10. Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli
11. Interaction of Bacillus subtilis Fur (ferric uptake repressor) with the dhb operator in vitro and in vivo
12. Characterization of the interaction between Fur and the iron transport promoter of the virulence plasmid in Vibrio anguillarum
13. Structural dynamics and functional domains of the Fur protein
14. Signal transduction and transcriptional and posttranscriptional control of iron-regulated genes in bacteria
15. Iron-dependent transcription of the frpB gene of Helicobacter pylori is controlled by the Fur repressor protein
16. Comparison of iron uptake in different Helicobacter species
17. The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin
18. Fur positive regulation of iron superoxide dismutase in Escherichia coli: Functional analysis of the sodB promoter
19. Metalloregulation in vitro of the aerobactin promoter of Escherichia coli by the Fur (ferric uptake regulation) protein
20. Coordinated repression in vitro of the divergent fepA-fes promoters of Escherichia coli by the iron uptake regulation (Fur) protein
21. Binding of the fur (ferric uptake regulator) repressor of Escherichia coli to arrays of the GATAAT sequence
22. Opening the iron box: Transcriptional metalloregulation by the Fur protein
23. Evidence of an unusually long operator for the fur repressor in the aerobactin promoter of Escherichia coli
24. Identification of iron-regulated genes of Helicobacter pylori by a modified fur titration assay (FURTA-Hp)
25. Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: Evidence for a third class of ferritins
26. Fur (ferric uptake regulation) protein interaction with target DNA: Comparison of gel retardation, footprinting and electron microscopy analyses
27. The role of fur in the acid tolerance response of Salmonella typhimurium is physiologically and genetically separable from its role in iron acquisition
28. Studies on transformation of Escherichia coli with plasmids
29. An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: Furmutants produce elevated alginate levels
30. A stable shuttle vector system for efficient genetic complementation of Helicobacter pylori strains by transformation and conjugation
31. In Staphylococcus aureus Fur is an interactive regulator with PerR, contributes to virulence, and is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis
32. Iron acquisition by Helicobacter pylori: Importance of human lactoferrin
33. The minus 35 recognition region of Escherichia coli sigma 70 is inessential for initiation of transcription at 'extended minus 10' promoter
34. Observation of binding and polymerization of Fur repressor onto operator-containing DNA with electron and atomic force microscopes
35. Role of iron in regulation of virulence genes
36. Operator sequences of the aerobactin operon of plasmid ColV-K30 binding the ferric uptake regulation (fur) repressor
37. Metal ion regulation of gene expression. Fur repressor-operator interaction at the promoter region of the aerobactin system of pColV-K30
38. A new method for sequencing DNA
39. Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: Cycle selection of iron-regulated genes
40. Role of ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: Purification and activity on iron-regulated promoters
41. Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori
42. Fur regulon in gram-negative bacteria. Identification and characterization of new iron-regulated Escherichia coli genes by a fur titration assay
43. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes
44. Iron and oxygen regulation of Escherichia coli MnSOD expression: Competition between the global regulators Fur and ArcA for binding to DNA
45. The complete genome sequence of the gastric pathogen Helicobacter pylori
46. The response of Pseudomonas aeruginosa to iron: Genetics, biochemistry and virulence
47. Multiple haem-utilization loci in Helicobacter pylori
48. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin
49. Molecular characterization of the ferric-uptake regulator, fur, from Staphylococcus aureus
50. Characterization of the DNA- and metal-binding properties of Vibrio anguillarum Fur reveals conservation of a structural Zn(2+) ion