Genomic evidence for the retention of the essential mycobacterial cell wall in the otherwise defective Mycobacterium leprae

Leprosy Review

Volumn 72, Issue 4, 2001, Pages 415-428

  Brennan, Patrick J ^a   Vissa, Varalakshmi D ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABINOGALACTAN; GENE PRODUCT; MANNOSIDE; MYCOLIC ACID; PEPTIDOGLYCAN; PHENOLIC GLYCOLIPID; PHOSPHATIDYLINOSITOL; PRENYLAMINE;

AMINO ACID COMPOSITION; AMINO ACID SYNTHESIS; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENOME; CELL ULTRASTRUCTURE; GENE MUTATION; GENE SEQUENCE; MORPHOLOGY; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN ANALYSIS; SEQUENCE ANALYSIS;

EID: 0035703675     PISSN: 03057518     EISSN: None     Source Type: Journal    
DOI: 10.5935/0305-7518.20010050     Document Type: Article

References (76)

1. Massive gene decay in the leprosy bacillus
2. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
3. Antituberculosis drug research
4. The genome of Mycobacterium leprae: A minimal mycobaacterial gene set
5. Studies of the mouse footpad technique for cultivation of Mycobaacterium leprae 3. Doubling time during logarithmic multiplication
6. Stability of Mycobacterium leprae and the temperature optimum for growth
7. The envelope of mycobacteria
8. Chemistry of the mycobacaterial cell wall
9. Mycobacterial lipoarabinomannan: An extraordinary lipoheteroglycan with profound physiological effects
10. Mycolic acids: Structure, biosynthesis and physiological functions
11. The cell-wall core of Mycobacterium: Structure, biogenesis and genetics
12. Genetics of cell wall biosynthesis
13. Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis
14. Electron microscopic observations of cell wall and cytoplasmic membrane in murine human leprosy bacilli
15. The bacteriology of Mycobacterium leprae
16. An electron microscope study of the band structure of the leprosy bacillus and other mycobacteria
17. Paracrystalline inclusions in Mycobacaterium leprae
18. Peptidoglycan and arabinogalactan of Mycobacterium leprae
19. Major structural features of the cell wall arabinogalactans of Mycobacterium, Rhodococcus, and Nocardia spp
20. Cell walls of Mycobacterium leprae
21. Demonstration that the galactosyl and arabinosyl residues in the cell-wall arabinogalactan of Mycobacterium leprae and Mycobacterium tuberculosis are furanoid
22. Evidence for the nature of the link between the arabinogalactan and peptidoglycan of mycobacterial cell walls
23. 13C NMR analyses
24. Location of the mycolyl ester substituents in the cell walls of mycobacteria
25. Quantitative comparison of the mycolic and fatty acid compositions of Mycobacterium leprae and Mycobacterium gordonae
26. A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927
27. The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis
28. Detection of trehalose monomycolate in Mycobacterium leprae grown in armadillo tissues
29. Evidence for the presence of a phosphatitidylinositol anchor on the lipoarabinomannan and lipomannan of Mycobacterium tuberculosis
30. Structural defnition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: Definition of a common anchor for lipomannan and lipoarabinomannan
31. Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium
32. A novel phenolic glycolipid from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity
33. Leprosy specific neoglycoconjugates: Synthesis and application to serodiagnosis of leprosy
34. Molecular basis for the peripheral nerve predilection of Mycobacterium leprae
35. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
36. Dual multimodular class A penicillin-binding proteins in Mycobacterium leprae
37. Identification and overexpression in Escherichia coli of a Mycobacterium leprae gene, ponI, encoding a high-molecular-mass class A penicillin-binding protein, PBP1
38. Comparison of the UDP-N-acetylmuramate: L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium leprae
39. Biosynthesis of the linkage region of the mycobacterial cell wall
40. Drug targeting Mycobacterium tuberculosis cell wall synthesis: Genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose
41. Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues
42. Recognition of the lipid intermediate for arabinogaiactan/arabinomannan biosyshtesis and its relation to the mode of action of ethambutol on mycobacteria
43. Biosynthesis of the galactan component of the mycobacterial cell wall
44. Polyprenylphosphate-pentoses in mycobacteria are synthesized from 5-phosphoribose pyrophosphate
45. Galactan biosynthesis in Mycobacterium tuberculosis: Identification of a bifunctional UDP-galactofuranosyltransferase
46. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacteriai drug ethambutol
47. The role of the embA, B gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogaiactan
48. Isoprenoid biosynthesis in bacteria: A novel pathway for the early steps leading to isopentenyl diphosphate
49. Purification and characterization of 1-deoxyxylulose 5-phosphate synthase from Mycobacterium tuberculosis
50. A 1-deoxy-D-xylulose 5-phosphate reductoisomease catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis
51. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: A novel system for the genetic analysis of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis
52. Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyldiphosphate in Escherichia coli
53. 50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis
54. Phosphatidylinositol is an essential phospholipid of mycobacteria
55. Biosynthesis of mycobacterial lipoarabinomannan
56. The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis
57. Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases
58. Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG
59. Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis
60. Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid
61. Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis
62. The biosynthesis of mycolic acids in Mycobacterium tuberculosis. Enzymatic methyl(ene) transfer to acyl carrier protein bound meromycolic acid in vitro
63. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis
64. Characterization of the in vivo acceptors of the mycoloyl residues transferred by the corynebacterial PS1 and the related mycobacterial antigens 85
65. Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria
66. Molecular cloning and sequencing of the gene for mycocerosic acid synthase, a novel fatty acid elongating multifunctional enzyme, from Mycobacterium tuberculosis var. bovis Bacillus Clamette-Guerin
67. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis: Evidence that this lipid is involved in the cell wall permeability barrier
68. Identification and recombinant expression of a Mycobacterium avium rhamnosyltransferase gene (rtfA) involved in glycopeptidolipid biosynthesis
69. Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae
70. Viable M.leprae as a research reagent