Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1

Molecular Cell

Volumn 8, Issue 6, 2001, Pages 1375-1382

  Vestergaard, Bente ^a   Van, Lan Bich ^a   Andersen, Gregers R ^a   Nyborg, Jens ^a   Buckingham, Richard H ^b   Kjeldgaard, Morten ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; POLYPEPTIDE; PROTEIN RF1; PROTEIN RF2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; EUKARYOTE; NONHUMAN; PROTEIN MOTIF; PROTEIN SECRETION; PROTEIN SYNTHESIS; STOP CODON;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA;

EID: 0035697089     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00415-4     Document Type: Article

References (22)

1. Ribosomal RNAs in translation termination: Facts and hypotheses
2. Crystallography & NMR system: A new software suite for macromolecular structure determination
3. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
4. The polypeptide chain release factor eRF1 specifically contacts the s(4)UGA stop codon located in the A site of eukaryotic ribosomes
5. The crystal structure of elongation factor G complexed with GDP, at 2.7 Å resolution
6. A post-translational modification in the GGQ motif of RF2 from Escherichia coli stimulates termination of translation
7. Release factor RF3 in E.coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner
8. Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis
9. Conserved motifs in prokaryotic and eukaryotic polypeptide release factors: tRNA-protein mimicry hypothesis
10. A tripeptide 'anticodon' deciphers stop codons in messenger RNA
11. Electron density map interpretation
12. The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution: Cleavage by Mg(2+) in 15-year old crystals
13. Translational termination comes of age
14. Class-1 polypeptide chain release factors are structurally and functionally similar to suppressor tRNAs and comprise different structural-functional families of prokaryotic/mitochondrial and eukaryotic/archaebacterial factors
15. phe, EF-Tu, and a GTP analog
16. Translational termination in Escherichia coli: Three bases following the stop codon crosslink to release factor 2 and affect the decoding efficiency of UGA-containing signals
17. Substitutions of the glutamine residue in ubiquitous GGQ tripeptide in human eRF1 do not entirely abolish the release factor activity
18. Crystal structure of Thermotoga maritima ribosome recycling factor: A tRNA mimic
19. The crystal structure of human eukaryotic release factor eRF1 - Mechanism of stop codon recognition and peptidyl-tRNA hydrolysis
20. Functional specificity of amino acid at position 246 in the tRNA mimicry domain of bacterial release factor 2
21. The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246
22. Crystal structure of the ribosome at 5.5 Å resolution