Overactivation of the protein kinase C-Signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae

Genetics

Volumn 159, Issue 4, 2001, Pages 1435-1448

  De Bettignies, Geoffroy ^a   Thoraval, Didier ^a   Morel, Carine ^a   Peypouquet, Marie France ^a   Crouzet, Marc ^a  

^a Institut de Biochimie et Genetique Cellulaires   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN KINASE C; RHO FACTOR;

ARTICLE; BACTERIAL GROWTH; CELL POLARITY; CYTOSKELETON; ENZYME ACTIVITY; GENE ACTIVATION; GENE CONTROL; GENE INTERACTION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SUPPRESSOR GENE;

ACTINS; BLOTTING, NORTHERN; DNA; FUNGAL PROTEINS; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; MUTATION; MYOSINS; PHENOTYPE; PHEROMONES; PLASMIDS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; RHO GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC; TIME FACTORS; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0035695057     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. The Rho GTPase Rho3 bas a direct role in exocytosis that is distinct from its role in actin polarity
2. Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene
3. First characterization of the gene RGD1 in the yeast Saccharomyces cerevisiae
4. The YDp plasmids: A uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae
5. Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance
6. Transformation in yeast: Development of a hybrid cloning vector and isolation of the CAN1 gene
7. A syanthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth
8. MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants
9. RGD1 genetically interacts with MID2 and SLG1, encoding two putative sensors for cell integrity signalling in Saccharomyces cerevisiae
10. Flow cytometry and cell sorting for yeast viability assessment and cell selection
11. The complete sequence of a 19,482 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae
12. The yeast Rgd1p is a GTPase activating protein of the Rho3 and Rho4 proteins
13. Rho1p, a yeast protein at the interface between cell polarization and morphogenesis
14. The GTP-binding protein Rho1p is required for cell cycle progression and polarization of the yeast cell
15. Origins of cell polarity
16. Dynamics and organization of MAP kinase signal pathways
17. Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis
18. Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae
19. A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and idenufication of a putative upstream regulator
20. The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae
21. MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ infux and mating
22. Genetic analysis of the Saccharomyes cerevisiae RHO3 gene, encoding a rho-type small GTPase, provides evidence for a role in bud formation
23. Bni1p and Bnr1p: Downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae
24. MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C
25. A screen for upstream components of the yeast protein kinase C signal transduction pathway identifies the product of the SLG1 gene
26. Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway
27. The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response
28. Activation of yeast protein kinase C by Rhol GTPase
29. Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway
30. Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae
31. Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog
32. A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C
33. A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle
34. Repression of ribosome and tRNA synthesis in secretion-defective cells is signaled by a novel branch of the cell integrity pathway
35. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae
36. The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae
37. Overexpression of MID2 suppresses the profilin-deficient phenotype of yeast cells
38. Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae
39. Molecular and functional characterization of a mutant allele of the mitogen-activated protein-kinase gene SLT2(MPK1) rescued from yeast autolytic mutants
40. Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae
41. Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae
42. Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1
43. Protein kinase C enables the regulatory circuit that connects membrane synthesis to ribosome synthesis in Saccharomyces cerevisiae
44. A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae
45. The MID2 gene encodes a putative integral membrane protein with a Ca(2+)-binding domain and shows mating pheromone-stimulated expression in Saccharomyces cerevisiae
46. Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae
47. Wsc1 and mid2 are cell surface sensors for cell wall integrity signaling that act through rom2, a guanine nucleotide exchange factor for rho1
48. Polarization of cell growth in yeast. Establishment and maintenance of polarity states
49. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae
50. Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70
51. A simple and highly efficient procedure for rescuing autonomous plasmids from yeast
52. Growth and handling of yeasts
53. Rpb4, a subunit of RNA polymerase II, enables the enzyme to transcribe at temperature extremes in intro
54. Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae
55. Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast
56. A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants
57. A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae
58. Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway
59. Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway
60. Periodic transcription as a means of regulating gene expression during the cell cycle: Contrasting mode of expression of DNA ligase genes in budding and fission yeast
61. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to Saccharomyces cerevisiae S288C
62. Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae