Gene therapy in rheumatic diseases

Best Practice and Research: Clinical Rheumatology

Volumn 15, Issue 5, 2001, Pages 771-788

  Vervoordeldonk, Margriet J B M ^a   Tak, Paul P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Animal models; Gene therapy; Human trial; Rheumatoid arthritis; Vectors

Indexed keywords

ADENOVIRUS VECTOR; ANTIRHEUMATIC AGENT; BETA INTERFERON; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 2; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA; DOMINANT NEGATIVE I KAPPA B KINASE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; GANCICLOVIR; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; OLIGONUCLEOTIDE; PROTEIN; RETROVIRUS VECTOR; THYMIDINE KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; BONE DESTRUCTION; CARTILAGE DEGENERATION; CELL FUNCTION; CHRONIC ARTHRITIS; CLINICAL TRIAL; DENDRITIC CELL; DISEASE ACTIVITY; DISEASE COURSE; DOSE RESPONSE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE THERAPY; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HUMAN; IMMUNOMODULATION; IN VIVO STUDY; LONG TERM CARE; LYMPHOCYTE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SAFETY; SYNOVIAL FLUID; TH1 CELL; TREATMENT PLANNING; VIRAL GENE DELIVERY SYSTEM;

EID: 0035693911     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1053/berh.2001.0193     Document Type: Article

References (67)

1. Examination of the synovium and synovial fluid
2. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis
3. Cytokines in rheumatoid arthritis: Trials and tribulations
4. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy
5. Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA
6. Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee
7. Direct gene delivery strategies for the treatment of rheumatoid arthritis
8. Mechanisms of action of interferon-beta in multiple sclerosis
9. Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells
10. The effects of interferon beta treatment on arthritis
11. Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy
12. Th1/Th2 cytokine balance in arthritis
13. IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis
14. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes
15. Synergistic activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis
16. Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model
17. NF-kappaB: A key role in inflammatory diseases
18. IkB kinase-beta (IKK-beta) is a key regulator of synovial inflammation
19. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction
20. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis
21. Amelioration of collagen-induced arthritis by CD95 (Apo-I/Fas)-ligand gene transfer
22. Novel gene therapy for rheumatoid arthritis by FADD gene transfer: Induction of apoptosis of rheumatoid synoviocytes but not chondrocytes
23. Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys
24. Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig
25. Differential effects of local application of BMP-2 or TGF-beta I on both articular cartilage composition and osteophyte formation
26. Stem cells for repair of cartilage and bone: The next challenge in osteoarthritis and rheumatoid arthritis
27. In vivo transfer of interleukin-I receptor antagonist gene in osteoarthritic rabbit knee joints: Prevention of osteoarthritis progression
28. Chondrocyte apoptosis induced by nitric oxide
29. Future of adenoviruses in the gene therapy of arthritis
30. Cellular immunity to viral antigens limits EI-deleted adenoviruses for gene therapy
31. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis
32. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses
33. Viral vectors for gene therapy
34. Lentiviral vectors: Turning a deadly foe into a therapeutic agent
35. Gene transfer with herpes simplex vectors
36. Intra-articular delivery of a herpes simplex virus IL-1 Ra gene vector reduces inflammation in a rabbit model of arthritis
37. Vector systems for gene transfer to joints
38. Stability of a functional murine satellite DNA-based artificial chromosome across mammalian species
39. C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
40. A targeted DNA vaccine augments the natural immune response to self TNF-alpha and suppresses ongoing adjuvant arthritis
41. Suppression of collagen-induced arthritis through adenovirus-mediated transfer of a modified tumor necrosis factor alpha receptor gene
42. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis
43. Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer
44. Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model
45. Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer
46. Human IL-1 Ra gene transfer into human synovial fibroblasts is chondroprotective
47. Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor
48. Pathogenic lymphoid cells engineered to express TGF beta 1 ameliorate disease in a collagen-induced arthritis model
49. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
50. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4
51. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer
52. Gene therapy of arthritis
53. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
54. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer
55. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
56. Intra-articular IL-4 gene therapy in arthritis: Anti-inflammatory effect and enhanced th2 activity
57. Disease-inducible to transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model
58. Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist
59. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
60. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study
61. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
62. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function
63. In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes
64. Clinical trials in the gene therapy of arthritis
65. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis
66. Gene therapy for autoimmune disorders
67. Studies illuminate cause of fatal reaction in gene therapy trial