Future of adenoviruses in the gene therapy of arthritis

Arthritis Research

Volumn 3, Issue 3, 2001, Pages 142-146

  Evans, Christopher H ^a   Ghivizzani, Steven C ^a   Oligino, Thomas A ^b   Robbins, Paul D ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Gene expression; Gene therapy; Immunity; Vector; Virus

Indexed keywords

CYTOKINE; GANCICLOVIR; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTEGRIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MACROGOL; MITOGEN ACTIVATED PROTEIN KINASE; ORNITHINE CARBAMOYLTRANSFERASE; THYMIDINE KINASE; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA; VIRUS PROTEIN; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; CHIMERA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SAFETY; EXPERIMENTAL ANIMAL; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC CODE; GENETIC ENGINEERING; GENOME; HUMAN; IN VIVO STUDY; LABORATORY TEST; MOUSE; NONHUMAN; NOTE; SYNOVIUM; TRANSGENE; VIRUS CHARACTERIZATION; VIRUS GENE; VIRUS INFECTION; VIRUS RECOMBINANT;

ADENOVIRUSES, HUMAN; ARTHRITIS, RHEUMATOID; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; OSTEOARTHRITIS; RECOMBINATION, GENETIC;

EID: 0035049849     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar291     Document Type: Note

References (40)

1. Adenovirus vectors for human gene therapy
2. Adenoviral-mediated gene transfer to rabbit synovium in vivo
3. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo
4. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
5. Genetic enhancement of matrix synthesis by articular chondrocytes: Comparison of different growth factor genes in the presence and absence of interleukin-1
6. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes
7. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
8. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation
9. Insulinlike growth factor-1 gene therapy applications for cartilage repair
10. Transfer of lacZ marker gene to the meniscus
11. Gene therapy for meniscal injury: Enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene
12. Gene transfer to the rabbit patellar tendon: Potential for genetic enhancement of tendon and ligament healing
13. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis
14. Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis
15. Suppression of collagen-induced arthritis through adenovirus-mediated transfer of a modified tumor necrosis factor alpha receptor gene
16. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees
17. Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction
18. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer
19. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws
20. Regulation of early adenovirus gene expression
21. Second-generation adenovirus vectors
22. Effect of the E4 region on the persistence of transgene expression from adenovirus vectors
23. A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase
24. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
25. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4
26. Modulation in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene
27. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
28. Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium
29. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
30. High adenoviral loads stimulate NF kappaB-dependent gene expression in human vascular smooth muscle cells
31. Gene therapy for rheumatic diseases
32. Gene transfer to synoviocytes: Prospects for gene treatment of arthritis
33. Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor
34. Molecular lysis of synovial lining cells by in vivo herpes simplex virus-thymidine kinase gene transfer
35. Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys
36. Gene therapy for autoimmune disorders
37. Potential treatment of osteoarthritis by gene therapy
38. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis
39. Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist
40. Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium